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    Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
    52.
    发明授权
    Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors 有权

    公开(公告)号：US11466033B2

    公开(公告)日：2022-10-11

    申请号：US16828243

    申请日：2020-03-24

    Applicant: ENANTA PHARMACEUTICALS, INC.

    Inventor： Brett Granger ,  Yong He ,  Guoqiang Wang ,  Yat Sun Or

    IPC: A61K31/4439 ,  C07D213/75 ,  C07D519/00 ,  C07D487/04

    Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).

    Process for Preparation of Sulfonyl Carbamate Bile Acid Derivatives
    59.
    发明申请
    Process for Preparation of Sulfonyl Carbamate Bile Acid Derivatives 审中-公开

    公开(公告)号：US20180291058A1

    公开(公告)日：2018-10-11

    申请号：US15948370

    申请日：2018-04-09

    Applicant: Enanta Pharmaceuticals, Inc.

    Inventor： Guoqiang Wang ,  Yong He ,  Brett Granger ,  Xuechao Xing ,  Yat Sun Or

    IPC: C07J41/00

    Abstract: The present invention relates to processes for preparing compounds of Formula (I) and compounds of Formula (II): or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGRS modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use.The present invention relates to a process for the preparation of the compounds of Formula (III), Formula (IV), Formula (V), and Formula (VI), The present invention also relates to a process for the preparation of compounds (VII), (VIII) and (IX),

    PROCESS FOR PREPARATION OF SULFONYLUREA BILE ACID DERIVATIVES
    60.
    发明申请
    PROCESS FOR PREPARATION OF SULFONYLUREA BILE ACID DERIVATIVES 审中-公开

    公开(公告)号：US20180148469A1

    公开(公告)日：2018-05-31

    申请号：US15826233

    申请日：2017-11-29

    Applicant: Enanta Pharmaceuticals, Inc.

    Inventor： Guoqiang Wang ,  Yong He ,  Peng Dai ,  Guoyou Xu ,  Bin Wang ,  Jiang Long ,  Yat Sun Or

    IPC: C07J41/00 ,  C07J9/00

    Abstract: The present invention relates to processes for preparing a compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGR5 modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use.The present invention relates to a process for the preparation of a compound (II) and its salts and derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of FXR and TGR5 modulators. The present invention also relates to a process for the preparation of a compound (III) and its diethylamine salt.

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