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公开(公告)号：US10696713B2
公开(公告)日：2020-06-30
申请号：US16222380
申请日：2018-12-17
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
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2.发明申请Bile Acid Derivatives as FXR/TGR5 Agonists and Methods of Use Thereof 审中-公开胆酸衍生物作为FXR / TGR5激动剂及其使用方法公开(公告)号：US20160176917A1
公开(公告)日：2016-06-23
申请号：US14976294
申请日：2015-12-21
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
CPC classification number: C07J43/003 , C07J41/0055 , C07J41/0088
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
Abstract translation: 本发明提供式I化合物，包含这些化合物的药物组合物以及使用这些化合物预防或治疗FXR介导的或TGR5介导的疾病或病症的方法。
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公开(公告)号：US10584145B2
公开(公告)日：2020-03-10
申请号：US15826233
申请日：2017-11-29
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yong He , Peng Dai , Guoyou Xu , Bin Wang , Jiang Long , Yat Sun Or
Abstract: The present invention relates to processes for preparing a compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGR5 modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use. The present invention relates to a process for the preparation of a compound (II) and its salts and derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of FXR and TGR5 modulators. The present invention also relates to a process for the preparation of a compound (III) and its diethylamine salt.
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公开(公告)号：US10208081B2
公开(公告)日：2019-02-19
申请号：US14951989
申请日：2015-11-25
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
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公开(公告)号：US20180237471A1
公开(公告)日：2018-08-23
申请号：US15896400
申请日：2018-02-14
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Xuechao Xing , Jiang Long , Peng Dai , Brett Granger , Jing He
CPC classification number: C07J41/005 , C07J9/005 , C07J41/0055 , C07J43/003 , C07J51/00
Abstract: The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, prodrugs and esters thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.
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Patent Agency Ranking
6.发明申请BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF 审中-公开双酸衍生物作为FXR / TGR5激动剂及其使用方法公开(公告)号：US20160185815A1
公开(公告)日：2016-06-30
申请号：US14951989
申请日：2015-11-25
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
CPC classification number: C07J41/0066 , C07J9/005 , C07J41/0055 , C07J41/0088 , C07J41/0094 , C07J43/003 , C07J43/006 , C07J51/00
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
Abstract translation: 本发明提供式I化合物，包含这些化合物的药物组合物和使用这些化合物预防或治疗FXR介导的或TGR5介导的疾病或病症的方法。
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公开(公告)号：US20210261600A1
公开(公告)日：2021-08-26
申请号：US17186447
申请日：2021-02-26
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
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公开(公告)号：US10968249B2
公开(公告)日：2021-04-06
申请号：US16878329
申请日：2020-05-19
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
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公开(公告)号：US20170240585A1
公开(公告)日：2017-08-24
申请号：US15439358
申请日：2017-02-22
Applicant: ENANTA PHARMACEUTICALS, INC.
Inventor： Guoqiang Wang , Yat Sun Or , Jiang Long , Guoyou Xu , Peng Dai , Ruichao Shen , Xuechao Xing , Jing He
CPC classification number: C07J41/0055 , C07B59/007 , C07B2200/05 , C07J9/005 , C07J17/00 , C07J43/003 , C07J51/00
Abstract: The present invention provides compounds of Formula (I) or Formula (II): pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR and/or TGR5.
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公开(公告)号：US20200347092A1
公开(公告)日：2020-11-05
申请号：US16878329
申请日：2020-05-19
Applicant: Enanta Pharmaceuticals, Inc.
Inventor： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
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