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    FREE BASE CRYSTALS
    51.
    发明公开
    FREE BASE CRYSTALS 审中-公开

    公开(公告)号：US20230174543A1

    公开(公告)日：2023-06-08

    申请号：US17997983

    申请日：2021-05-06

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI

    IPC: C07D487/14

    CPC classification number: C07D487/14 ,  C07B2200/13

    Abstract: The present invention relates to crystals of (6aR, 9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-α]pyrazolo[4,3-e]pyrazolo[4,3-e]pyrimidin-4(2H)-one, and methods of making and using such crystals.

    METHODS OF TREATMENT
    52.
    发明申请
    METHODS OF TREATMENT 有权

    公开(公告)号：US20220354851A1

    公开(公告)日：2022-11-10

    申请号：US17640050

    申请日：2020-09-03

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Robert DAVIS

    IPC: A61K31/519 ,  A61K31/505 ,  A61K38/00 ,  A61P35/00

    Abstract: The disclosure relates to the combination of inhibitors of phosphodiesterase 1 (PDE1) useful for the treatment of certain cancers or tumors, such as colon cancer. In another embodiment, the disclosure relates to the use of inhibitors of PDE1 and an optional antitumor agent for the treatment of certain cancers or tumors.

    ORGANIC COMPOUNDS
    54.
    发明申请
    ORGANIC COMPOUNDS 有权

    公开(公告)号：US20220008423A1

    公开(公告)日：2022-01-13

    申请号：US17379399

    申请日：2021-07-19

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Wei YAO ,  Peng LI

    IPC: A61K31/519 ,  C07D471/14 ,  A61P25/28 ,  A61K31/4985 ,  A61K45/06 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24

    Abstract: The invention relates to particular substituted deuterated heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D1/D2 receptor signaling systems, and/or the treatment of residual symptoms.

    NOVEL COMPOSITIONS AND METHODS
    55.
    发明申请
    NOVEL COMPOSITIONS AND METHODS 有权

    公开(公告)号：US20210361648A1

    公开(公告)日：2021-11-25

    申请号：US17338573

    申请日：2021-06-03

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Wei YAO ,  Robert DAVIS

    IPC: A61K31/4985 ,  A61K9/06 ,  A61K9/00

    Abstract: The disclosure provides new transmucosal and subcutaneous pharmaceutical compositions comprising 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one or 1-(4-fluoro-phenyl)-4-((6bR,10aS)-2,2-d2-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one or comprising -(4-fluoro-phenyl)-4-((6bR,10aS)-1,1,2,2-d4-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one, in free base, co-crystal or salt form, together with methods of making and using them.

    AMORPHOUS SOLID DISPERSIONS
    59.
    发明申请
    AMORPHOUS SOLID DISPERSIONS 审中-公开

    公开(公告)号：US20190388418A1

    公开(公告)日：2019-12-26

    申请号：US16341806

    申请日：2017-10-03

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI

    IPC: A61K31/4985 ,  A61K9/00 ,  A61K47/38

    Abstract: The disclosure provides new, stable, pharmaceutically acceptable amorphous solid dispersions of 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one, together with methods of making and using them, and pharmaceutical compositions comprising them.

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