公开(公告)号：US20240109949A1

公开(公告)日：2024-04-04

申请号：US18529656

申请日：2023-12-05

Applicant: Immatics Biotechnologies GmbH

Inventor： Jens HUKELMANN ,  Heiko SCHUSTER ,  Lena WULLKOPF ,  Christoph SCHRAEDER ,  Jens FRITSCHE ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Oliver SCHOOR

IPC: C07K14/725 ,  A61K35/17 ,  C07K14/74 ,  C07K16/28

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70539 ,  C07K16/2833 ,  A61K38/00

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230331807A1

公开(公告)日：2023-10-19

申请号：US18314727

申请日：2023-05-09

Applicant: Immatics Biotechnologies GmbH

Inventor： Heiko SCHUSTER ,  Daniel Johannes KOWALEWSKI ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Toni WEINSCHENK ,  Harpreet SINGH ,  Gisela SCHIMMACK ,  Michael ROEMER

IPC: G01N33/574 ,  C07K16/28 ,  A61K9/19 ,  A61K39/00 ,  G16B25/10 ,  C07K14/725 ,  C12N15/115 ,  C12N5/0783 ,  A61P35/00 ,  C07K14/74 ,  A61K35/17

CPC classification number: C07K14/7051 ,  A61K9/19 ,  A61K35/17 ,  A61K39/001111 ,  A61P35/00 ,  C07K14/70539 ,  C07K16/2809 ,  C07K16/2833 ,  C12N5/0638 ,  C12N15/115 ,  G01N33/57492 ,  G16B25/10 ,  A61K38/00

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20220226376A1

公开(公告)日：2022-07-21

申请号：US17576866

申请日：2022-01-14

Applicant: Immatics Biotechnologies GmbH

Inventor： Ricarda HANNEN ,  Jens HUKELMANN ,  Florian KOEHLER ,  Daniel Johannes KOWALEWSKI ,  Heiko SCHUSTER ,  Oliver SCHOOR ,  Michael ROEMER ,  Chih-Chiang TSOU ,  Jens FRITSCHE

IPC: A61K35/17 ,  A61P35/00 ,  A61K39/00 ,  C12N5/0783 ,  C07K14/47

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220008471A1

公开(公告)日：2022-01-13

申请号：US17484452

申请日：2021-09-24

Applicant: Immatics Biotechnologies GmbH

Inventor： Gisela SCHIMMACK ,  Annika SONNTAG ,  Heiko SCHUSTER ,  Daniel Johannes KOWALEWSKI ,  Michael ROEMER ,  Jens FRITSCHE ,  Oliver SCHOOR ,  Toni WEINSCHENK ,  Harpreet SINGH

IPC: A61K35/17 ,  A61K39/00 ,  C07K14/73 ,  C07K14/705 ,  C07K14/74

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.