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    Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition
    51.
    发明授权
    Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition 失效
    四氢吲哚酮衍生物作为增加认知的gabaaalpha5配体

    公开(公告)号：US06395766B1

    公开(公告)日：2002-05-28

    申请号：US09674740

    申请日：2000-11-06

    申请人： Howard Barff Broughton ,  Helen Jane Bryant ,  Mark Stuart Chambers ,  Neil Roy Curtis

    发明人： Howard Barff Broughton ,  Helen Jane Bryant ,  Mark Stuart Chambers ,  Neil Roy Curtis

    IPC分类号： A61K31404

    CPC分类号： C07D401/04 ,  A61K31/40 ,  C07D209/08 ,  C07D401/14 ,  C07D403/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

    摘要： Compounds according to Formula (I) or a pharmaceutically acceptable salt thereof are GABA-A Alpha 5 ligands useful for enhancing cognition: where A is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, arylC1-6alkyl, or aryl wherein the aryl group is optionally substituted by halogen, C1-6alkyl, CF3, CN, NO2 or NH2, NR1R10, S(O)pR1, heteroarylC1-6alkyl or heteroaryl where heteroaryl is a 5- or 6-membered heteroaromatic ring as defined for B; and B is phenyl or a 5-membered ring having one or two unsaturations containing 1, 2, 3, or 4 heteroatoms chosen from O, N and S provided that not more than one heteroatom is other than N, a 6-membered heteroaromatic ring containing 1, 2, 3 or 4 nitrogen atoms, each of which rings is optionally substituted by one or more substituents.

    摘要翻译： 根据式（I）的化合物或其药学上可接受的盐是可用于增强认知的GABA-Aα5配体：其中A是C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基，芳基C 1-6烷基或芳基 其中芳基任选被卤素，C 1-6烷基，CF 3，CN，NO 2或NH 2，NR 1 R 10，S（O）p R 1，杂芳基C 1-6烷基或杂芳基取代，其中杂芳基是5-或6-元杂芳环， B; 并且B是苯基或具有1或2个不饱和基团的5元环，其含有1,2,3或4个选自O，N和S的杂原子，条件是不超过一个杂原子不是N，6元杂芳环 含有1,2,3或4个氮原子，其中每个环任选被一个或多个取代基取代。