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公开(公告)号:US5719147A
公开(公告)日:1998-02-17
申请号:US525259
申请日:1995-09-08
申请人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm MacCoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
发明人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm MacCoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
IPC分类号: C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , A61K31/54 , A61K31/535 , C07D417/04
CPC分类号: C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , Y10S514/825
摘要: Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
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公开(公告)号:US06638930B2
公开(公告)日:2003-10-28
申请号:US09836716
申请日:2001-04-17
申请人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
发明人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
IPC分类号: A61K315377
CPC分类号: A61K31/41 , A61K31/50 , A61K31/53 , A61K31/535 , A61K31/54 , C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , Y10S514/872
摘要: Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
摘要翻译: 取代的通式结构式的杂环是用于治疗炎性疾病,疼痛或偏头痛,哮喘和呕吐的速激肽受体拮抗剂,以及可用于治疗心血管疾病如心绞痛,高血压或缺血的钙通道阻滞剂。
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公开(公告)号:US5872116A
公开(公告)日:1999-02-16
申请号:US959393
申请日:1997-10-28
申请人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
发明人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
IPC分类号: C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , A61K31/54 , A61K31/50 , A61K31/53 , A61K31/535
CPC分类号: C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , Y10S514/825
摘要: Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
摘要翻译: 取代的通式结构式的杂环:
是可用于治疗炎性疾病,疼痛或偏头痛,哮喘和呕吐的速激肽受体拮抗剂,以及可用于治疗心血管疾病如心绞痛,高血压或缺血的钙通道阻滞剂。 -
公开(公告)号:US06235735B1
公开(公告)日:2001-05-22
申请号:US09526843
申请日:2000-03-16
申请人: Conrad P. Dorn , Jeffrey J Hale , Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Tamara Ladduwahetty , Timothy Harrison , Brian John Williams
发明人: Conrad P. Dorn , Jeffrey J Hale , Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Tamara Ladduwahetty , Timothy Harrison , Brian John Williams
IPC分类号: A61K315355
CPC分类号: A61K31/41 , A61K31/50 , A61K31/53 , A61K31/535 , A61K31/54 , C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , Y10S514/872
摘要: Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
摘要翻译: 取代的通式结构式的杂环是用于治疗炎性疾病,疼痛或偏头痛,哮喘和呕吐的速激肽受体拮抗剂,以及可用于治疗心血管疾病如心绞痛,高血压或缺血的钙通道阻滞剂。
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公开(公告)号:US06048859A
公开(公告)日:2000-04-11
申请号:US251190
申请日:1999-02-16
申请人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
发明人: Conrad P. Dorn , Paul E. Finke , Jeffrey J. Hale , Malcolm Maccoss , Sander G. Mills , Shrenik K. Shah , Mark Stuart Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian John Williams
IPC分类号: A61K31/41 , A61K31/50 , A61K31/53 , A61K31/535 , A61K31/5355 , A61K31/54 , A61P1/08 , A61P13/10 , C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14
CPC分类号: A61K31/41 , A61K31/50 , A61K31/53 , A61K31/535 , A61K31/54 , C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , Y10S514/872
摘要: Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
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公开(公告)号:US5637699A
公开(公告)日:1997-06-10
申请号:US445489
申请日:1995-05-22
申请人: Conrad P. Dorn , Jeffrey J. Hale , Paul E. Finke , Malcolm MacCoss , Sander G. Mills , Shrenik K. Shah , Mark S. Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian J. Williams
发明人: Conrad P. Dorn , Jeffrey J. Hale , Paul E. Finke , Malcolm MacCoss , Sander G. Mills , Shrenik K. Shah , Mark S. Chambers , Timothy Harrison , Tamara Ladduwahetty , Brian J. Williams
IPC分类号: C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14 , C07D413/02 , C07D265/28 , C07D265/34
CPC分类号: C07D265/30 , C07D265/32 , C07D279/12 , C07D413/04 , C07D413/06 , C07D413/14
摘要: Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
摘要翻译: 取代的通式结构式的杂环:
是可用于治疗炎性疾病,疼痛或偏头痛,哮喘和呕吐的速激肽受体拮抗剂,以及可用于治疗心血管疾病如心绞痛,高血压或缺血的钙通道阻滞剂。 -
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公开(公告)号:US6096729A
公开(公告)日:2000-08-01
申请号:US980928
申请日:1997-12-01
申请人: Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
发明人: Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
IPC分类号: C07D491/107 , A61K31/00 , A61K31/395 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/4525 , A61K31/5375 , A61K31/5377 , A61K31/675 , A61K45/00 , A61P9/10 , A61P25/28 , C07D211/56 , C07D265/32 , C07D413/06 , C07D491/10 , A61K31/44 , A61K31/535
CPC分类号: A61K31/661 , A61K31/00 , A61K31/395 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/5375 , A61K31/5377 , A61K31/675 , C07D211/56 , C07D491/10
摘要: The present invention provides methods for the treatment or prevention of amnestic disorders which comprises oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist.
摘要翻译: 本发明提供了治疗或预防遗忘性疾病的方法,其包括口服活性的长效中枢神经系统(CNS)渗透的NK-1受体拮抗剂的口服给药。
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公开(公告)号:US07598386B2
公开(公告)日:2009-10-06
申请号:US11788888
申请日:2007-04-23
申请人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
发明人: Jose Luis Castro Pineiro , Ian Churcher , Kevin Dinnell , Timothy Harrison , Sonia Kerrad , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Martin Richard Teall , Susannah William , Brian John Williams
IPC分类号: C07D211/00 , C07D211/68 , C07D211/40 , C07D211/70 , C07D309/00
CPC分类号: C07D207/27 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D207/12 , C07D207/404 , C07D211/18 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/32 , C07D233/40 , C07D233/56 , C07D233/64 , C07D241/18 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D263/38 , C07D263/44 , C07D271/06 , C07D277/26 , C07D285/12 , C07D295/088 , C07D295/096 , C07D295/182 , C07D307/52 , C07D309/08 , C07D309/10 , C07D317/48 , C07D317/72 , C07D491/10 , C07F7/0812
摘要: Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.
摘要翻译: 公开了式I的新型砜:其中A完成任选包含最多两个杂原子的4-7元环。 该化合物调节γ-分泌酶的作用,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US07410964B2
公开(公告)日:2008-08-12
申请号:US10555034
申请日:2004-05-07
申请人: Kevin Dinnell , Karl Richard Gibson , Timothy Harrison , Richard Alexander Jelley , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
发明人: Kevin Dinnell , Karl Richard Gibson , Timothy Harrison , Richard Alexander Jelley , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
IPC分类号: C07D285/22 , A61K31/5415
CPC分类号: C07D279/02
摘要: Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.
摘要翻译: 式I化合物:抑制γ-分泌酶,因此可用于治疗或预防阿尔茨海默氏病。
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公开(公告)号:US6087348A
公开(公告)日:2000-07-11
申请号:US328743
申请日:1999-06-09
申请人: Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
发明人: Raymond Baker , Neil Roy Curtis , Jason Matthew Elliott , Timothy Harrison , Gregory John Hollingworth , Philip Stephen Jackson , Janusz Jozef Kulagowski , Nadia Melanie Rupniak , Eileen Mary Seward , Christopher John Swain , Brian John Williams
IPC分类号: A61K31/44 , A61K31/535 , A61K31/675 , A61K31/4445
CPC分类号: A61K31/44 , A61K31/535 , A61K31/675
摘要: The present invention provides the use of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist for the manufacture of a medicament adapted for oral administration for the treatment or prevention of stress disorders without concomitant therapy with other anti-stress agents, methods of treatment using such a NK-1 receptor antagonist and pharmaceutical compositions comprising it.
摘要翻译: 本发明提供口服活性的长效CNS渗透剂NK-1受体拮抗剂在制备适于口服给药以治疗或预防应激障碍的药物中的用途,而不与其它抗应激剂同时治疗, 使用这样的NK-1受体拮抗剂的药物组合物的方法和包含它的药物组合物。
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