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公开(公告)号：US12065437B2
公开(公告)日：2024-08-20
申请号：US17192985
申请日：2021-03-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Carolyn Diane Dzierba , John E. Macor
IPC: C07D471/04 , A61K31/4427 , A61K31/50 , A61P25/28 , C07C233/25 , C07D213/30 , C07D213/34 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D215/14 , C07D237/08 , C07D239/26 , C07D309/18 , C07D309/22 , C07D401/04 , C07D401/14 , C07D413/10
CPC classification number: C07D471/04 , A61K31/4427 , A61K31/50 , A61P25/28 , C07C233/25 , C07D213/30 , C07D213/34 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D215/14 , C07D237/08 , C07D239/26 , C07D309/18 , C07D309/22 , C07D401/04 , C07D401/14 , C07D413/10
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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2.发明公开公开(公告)号：US20240269134A1
公开(公告)日：2024-08-15
申请号：US18621976
申请日：2024-03-29
Applicant: Tenax Therapeutics, Inc.
Inventor： Stuart Rich , Douglas Randall , Douglas Hay
IPC: A61K31/50 , A61K9/00 , A61K31/216 , A61K31/41 , A61K31/495 , A61K31/502 , A61K31/55 , A61K31/7048 , A61K38/22 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/40 , A61P9/04 , A61P9/12
CPC classification number: A61K31/50 , A61K9/0019 , A61K9/0053 , A61K31/216 , A61K31/41 , A61K31/495 , A61K31/502 , A61K31/55 , A61K31/7048 , A61K38/2221 , A61K38/2242 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/40 , A61P9/04 , A61P9/12
Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.
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公开(公告)号：US20240254079A1
公开(公告)日：2024-08-01
申请号：US18239892
申请日：2023-08-30
Applicant: ARCUS BIOSCIENCES, INC.
Inventor： Joel Worley BEATTY , Samuel Lawrie DREW , Matthew EPPLIN , Jeremy Thomas Andre FOURNIER , Balint GAL , Tezcan GUNEY , Karl T. HAELSIG , Clayton HARDMAN , Steven Donald JACOB , Jenna Leigh JEFFREY , Jaroslaw KALISIAK , Kenneth Victor LAWSON , Manmohan Reddy LELETI , Erick Allen LINDSEY , Artur Karenovich MAILYAN , Debashis MANDAL , Guillaume MATA , Hyunyoung MOON , Jay Patrick POWERS , Brandon Reid ROSEN , Yongli SU , Anh Thu TRAN , Zhang WANG , Xuelei YAN , Kai YU
IPC: C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
CPC classification number: C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/3955 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04 , C07C2602/08 , C07C2602/10
Abstract: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号：US11986481B2
公开(公告)日：2024-05-21
申请号：US18393813
申请日：2023-12-22
Applicant: Madrigal Pharmaceuticals, Inc. , Hoffmann-La Roche Inc.
Inventor： Martha J. Kelly , Rebecca Taub , Edward Hung Yang Chiang
IPC: A61K31/53 , A61K31/50 , A61P5/14 , A61P9/00 , C07D237/16 , C07D403/02 , C07D403/12
CPC classification number: A61K31/53 , A61K31/50 , A61P5/14 , A61P9/00 , C07D237/16 , C07D403/02 , C07D403/12 , C07B2200/13 , Y02P20/55
Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.
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公开(公告)号：US11969424B2
公开(公告)日：2024-04-30
申请号：US17122921
申请日：2020-12-15
Applicant: Tenax Therapeutics, Inc.
Inventor： Stuart Rich , Douglas Randall , Douglas Hay
IPC: A61K31/50 , A61K9/00 , A61K31/216 , A61K31/41 , A61K31/495 , A61K31/502 , A61K31/55 , A61K31/7048 , A61K38/22 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/40 , A61P9/04 , A61P9/12
CPC classification number: A61K31/50 , A61K9/0019 , A61K9/0053 , A61K31/216 , A61K31/41 , A61K31/495 , A61K31/502 , A61K31/55 , A61K31/7048 , A61K38/2221 , A61K38/2242 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/40 , A61P9/04 , A61P9/12
Abstract: This invention relates to the treatment of Pulmonary Hypertension with heart failure with preserved ejection fraction (PH-HFpEF). More specifically, embodiments of the invention provide compositions and methods useful for the treatment of PH-HFpEF employing the use of levosimendan.
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Patent Agency Ranking
6.发明授权公开(公告)号：US11806337B2
公开(公告)日：2023-11-07
申请号：US17875216
申请日：2022-07-27
Inventor： Stephen Gardell , Anthony B. Pinkerton , Eduard Sergienko , Hampton Sessions
IPC: A61K31/4409 , A61K31/196 , A61K31/245 , A61K31/415 , A61K31/4155 , A61K31/417 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4355 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , A61K31/5386 , C07C275/42 , C07D213/40 , C07D213/56 , C07D213/643 , C07D213/73 , C07D213/74 , C07D231/12 , C07D233/64 , C07D237/08 , C07D239/26 , C07D249/04 , C07D261/08 , C07D263/32 , C07D277/28 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D498/08
CPC classification number: A61K31/4409 , A61K31/196 , A61K31/245 , A61K31/415 , A61K31/417 , A61K31/4155 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/4355 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/444 , A61K31/4406 , A61K31/4418 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , A61K31/5386 , C07C275/42 , C07D213/40 , C07D213/56 , C07D213/643 , C07D213/73 , C07D213/74 , C07D231/12 , C07D233/64 , C07D237/08 , C07D239/26 , C07D249/04 , C07D261/08 , C07D263/32 , C07D277/28 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D498/08
Abstract: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
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7.发明授权公开(公告)号：US11793821B2
公开(公告)日：2023-10-24
申请号：US17193550
申请日：2021-03-05
Applicant: Merck Sharp & Dohme LLC
Inventor： Brendan M. Crowley , Ian M. Bell , Andrew John Harvey
IPC: A61K31/695 , A61K31/198 , A61K31/4164 , A61K31/4196 , A61K31/4245 , A61K31/4418 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/34 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D271/06 , C07D401/04 , C07D413/04 , C07F7/08
CPC classification number: A61K31/695 , A61K31/198 , A61K31/4164 , A61K31/4196 , A61K31/4245 , A61K31/4418 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/34 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D271/06 , C07D401/04 , C07D413/04 , C07F7/0812
Abstract: The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：US20180235961A1
公开(公告)日：2018-08-23
申请号：US15752130
申请日：2016-08-12
Inventor： Luc De Waal , Matthew Meyerson , Heidi Greulich , Monica Schenone , Alex Burgin , Xiaoyun Wu , Ulrike Sack
IPC: A61K31/50 , A61K9/00 , A61P35/00 , G01N33/574
CPC classification number: A61K31/50 , A61K9/0019 , A61K9/0053 , A61K31/519 , A61K2300/00 , A61P35/00 , G01N33/57488 , G01N2333/916 , G01N2800/52
Abstract: The present invention features improved methods of identifying patients having cancer (e.g., melanoma, adenocarcinoma, lung, cervical, liver or breast cancer) using biomarkers (e.g., PDE3A, SLFN12) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., DNMDP, zardaverine, and anagrelide).
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9.发明申请公开(公告)号：US20180162889A1
公开(公告)日：2018-06-14
申请号：US15838434
申请日：2017-12-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael G. YANG , Zili Xiao , John V. Duncia , David S. Weinstein
IPC: C07F9/6558 , C07F9/6509 , A61P37/00 , A61P29/00
CPC classification number: C07F9/65583 , A61K31/50 , A61K31/501 , A61P29/00 , A61P37/00 , C07D237/24 , C07D401/12 , C07F9/650905
Abstract: Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US20180134704A1
公开(公告)日：2018-05-17
申请号：US15865848
申请日：2018-01-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Ling Chen , Carolyn Diane Dzierba , Jonathan L. Ditta , John E. Macor , Joanne J. Bronson
IPC: C07D471/04 , C07D413/10 , A61K31/50 , C07D401/04 , C07D309/22 , C07D239/26 , C07D237/08 , C07D215/14 , C07D213/80 , C07D213/75 , C07D213/73 , C07D213/64 , C07D213/61 , C07D213/57 , C07D213/34 , C07D213/30 , C07C233/25 , C07D401/14
CPC classification number: C07D471/04 , A61K31/4427 , A61K31/50 , A61P25/28 , C07C233/25 , C07D213/30 , C07D213/34 , C07D213/57 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D215/14 , C07D237/08 , C07D239/26 , C07D309/18 , C07D309/22 , C07D401/04 , C07D401/14 , C07D413/10
Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
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