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51.发明授权Polysubstituted indan-1-ol systems for the prophylaxis or treatment of obesity 有权用于预防或治疗肥胖症的多取代的茚满-1-醇系统公开(公告)号：US06812257B2
公开(公告)日：2004-11-02
申请号：US10692721
申请日：2003-10-27
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： A61K3110
CPC分类号： A61K31/10 , A61K31/137 , A61K31/365 , A61K31/4184 , A61K38/2264 , A61K2300/00
摘要： Polysubstituted indan-1-ol compounds of formula I, its physiologically acceptable salts and physiologically functional derivatives are disclosed Compositions comprising the same, methods of preparation and methods for the prophylaxis or treatment of obesity are also disclosed herein.
摘要翻译： 公开了式I的多取代茚满-1-醇，其生理上可接受的盐和生理功能性衍生物。本文还公开了包含其的组合物，制备方法和预防或治疗肥胖症的方法。
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52.发明授权C2-substituted indan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals 有权C2取代的茚满-1-醇及其衍生物，其制备方法及其作为药物的用途公开(公告)号：US06657086B2
公开(公告)日：2003-12-02
申请号：US10231394
申请日：2002-08-30
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： C07C31700
CPC分类号： C07C323/17 , C07C317/20 , C07C2602/08
摘要： Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.
摘要翻译： 本发明的实施方案涉及C2-取代的茚满-1-醇及其生理上可接受的盐和生理功能衍生物。 本发明的实施方案的化合物可以包括式Iin的化合物，其中基团如所定义，及其生理上可接受的盐及其制备方法。 这些化合物适用于例如用作止痛剂。
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53.发明授权公开(公告)号：US06387935B1
公开(公告)日：2002-05-14
申请号：US09706351
申请日：2000-11-06
IPC分类号： A61K31428
CPC分类号： C07D277/60 , A61K31/425 , A61K31/428
摘要： The invention relates to polycyclic dihydrothiazoles, and to their physiologically acceptable salts and physiologically functional derivatives. The compounds are according to formula I: in which the radicals have the meanings indicated, and their physiologically acceptable salts and process for their preparation are described. The compounds are suitable, for example, for use as anorectics.
摘要翻译： 本发明涉及多环二氢噻唑及其生理上可接受的盐和生理功能衍生物。 该化合物是根据式I所示：其中基团具有所示的含义，并描述了它们的生理上可接受的盐及其制备方法。 这些化合物适用于例如用作止痛剂。
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公开(公告)号：US20050089555A1
公开(公告)日：2005-04-28
申请号：US10970815
申请日：2004-10-21
申请人： Peter Boderke , Rainer Pooth , Juergen Sandow , Matthias Gossel , Karl-Heinz Nietsch , Gerhard Sattler , Gerhard Vogel
发明人： Peter Boderke , Rainer Pooth , Juergen Sandow , Matthias Gossel , Karl-Heinz Nietsch , Gerhard Sattler , Gerhard Vogel
IPC分类号： A61K9/00 , A61K9/127 , A61K31/409 , A61K31/685 , A61K45/06 , A61K47/28 , A61K31/56
CPC分类号： A61K9/0019 , A61K9/127 , A61K31/409 , A61K31/685 , A61K45/06 , A61K47/28 , A61K2300/00
摘要： Aqueous phospholipid systems comprising at least one phospholipid, at least one bile acid and water are suitable for producing medicaments for the treatment of adipose tissue disorders and lead to regression of the pathologically proliferated adipose tissue.
摘要翻译： 包含至少一种磷脂，至少一种胆汁酸和水的磷脂体系适用于制备用于治疗脂肪组织病症的药物并导致病理性增殖的脂肪组织消退。
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55.发明授权Derivatives of C2-substituted indan-1-ol compounds, methods for their preparation and use 有权C2取代的茚满-1-醇化合物的衍生物，其制备和使用方法公开(公告)号：US06717008B2
公开(公告)日：2004-04-06
申请号：US10231365
申请日：2002-08-30
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： C07C30900
CPC分类号： C07C317/20 , C07C323/17 , C07C2602/08
摘要： Derivatives of C2-substituted indan-1-ol compounds, processes for their preparation and their use are disclosed. In particular, the invention relates to compounds of the formula I and to their physiologically acceptable salts and physiologically functional derivatives. The compounds are suitable, for example, for use as anorectics.
摘要翻译： 公开了C2-取代的茚满-1-醇化合物的衍生物，其制备方法及其应用。 特别地，本发明涉及式I化合物及其生理上可接受的盐和生理功能衍生物。 这些化合物适用于例如用作止痛剂。
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![Substituted 8,8a-dihydro-3ah-indeno[1,2-d]thiazoles, processes for their preparation and their use as medicaments](/abs-image/US/2002/06/25/US06410577B1/abs.jpg.150x150.jpg)
公开(公告)号：US06410577B1
公开(公告)日：2002-06-25
申请号：US09790905
申请日：2001-02-23
IPC分类号： C07D27760
摘要： The invention relates to substituted 8,8a-dihydro-3aH-indeno[1,2-d]thiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
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公开(公告)号：US20090275545A1
公开(公告)日：2009-11-05
申请号：US12459952
申请日：2009-07-10
申请人： Peter Boderke , Rainer Pooth , Juergen Sandow , Matthias Gossel , Karl-Heinz Nietsch , Gerhard Sattler , Gerhard Vogel
发明人： Peter Boderke , Rainer Pooth , Juergen Sandow , Matthias Gossel , Karl-Heinz Nietsch , Gerhard Sattler , Gerhard Vogel
IPC分类号： A61K31/575 , A61P43/00
CPC分类号： A61K9/0019 , A61K9/127 , A61K31/409 , A61K31/685 , A61K45/06 , A61K47/28 , A61K2300/00
摘要： Aqueous phospholipid systems comprising at least one phospholipid, at least one bile acid and water are suitable for producing medicaments for the treatment of adipose tissue disorders and lead to regression of the pathologically proliferated adipose tissue.
摘要翻译： 包含至少一种磷脂，至少一种胆汁酸和水的磷脂体系适用于制备用于治疗脂肪组织病症的药物并导致病理性增殖的脂肪组织消退。
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公开(公告)号：US07081467B2
公开(公告)日：2006-07-25
申请号：US10230464
申请日：2002-08-29
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： A61K31/10 , A61K31/41 , A61K31/42 , A61K31/4418 , A61K31/4192 , A61K31/425 , C07C317/12 , C07D213/24
CPC分类号： C07C317/24 , C07C323/22 , C07C2602/08
摘要： The present invention is directed C2-disubstituted indan-1-ones of the Formula I, physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical compositions comprising such compounds, salts and derivatives, which are useful for reducing weight, for the prophylaxis or treatment of obesity, and for the prophylaxis or treatment of type II diabetes in mammals. The invention is directed also to methods for reducing weight and such treatments and prophylaxis. The invention is directed also to processes for the preparation of such compounds.
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59.发明授权C2-substituted idan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals 有权C2取代的异头烷-1-醇及其衍生物，其制备方法及其作为药物的用途公开(公告)号：US07045649B2
公开(公告)日：2006-05-16
申请号：US10664855
申请日：2003-09-22
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： C07C321/00
CPC分类号： C07C323/17 , C07C317/20 , C07C2602/08
摘要： Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.
摘要翻译： 本发明的实施方案涉及C2-取代的茚满-1-醇及其生理上可接受的盐和生理功能衍生物。 本发明实施方案的化合物可包括其中基团如所定义的式I化合物及其生理上可接受的盐及其制备方法。 这些化合物适用于例如用作止痛剂。
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60.发明申请C2-substituted idan-1-ols and their derivatives, processes for their preparation and their use as pharmaceuticals 有权C2取代的异头烷-1-醇及其衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050101798A1
公开(公告)日：2005-05-12
申请号：US10664855
申请日：2003-09-22
申请人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
发明人： Gerhard Jaehne , Volker Krone , Martin Bickel , Matthias Gossel
IPC分类号： C07D239/38 , A61K31/10 , A61K31/18 , A61K31/423 , A61K31/4402 , A61K31/505 , A61P3/04 , A61P3/10 , C07C315/02 , C07C315/04 , C07C317/20 , C07C317/48 , C07C317/50 , C07C319/14 , C07C323/17 , C07C323/58 , C07C323/59 , C07D213/71 , C07D263/58 , C07C323/07
CPC分类号： C07C323/17 , C07C317/20 , C07C2602/08
摘要： Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.
摘要翻译： 本发明的实施方案涉及C2-取代的茚满-1-醇及其生理上可接受的盐和生理功能衍生物。 本发明实施方案的化合物可包括其中基团如所定义的式I化合物及其生理上可接受的盐及其制备方法。 这些化合物适用于例如用作止痛剂。
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