公开(公告)号：US4628158A

公开(公告)日：1986-12-09

申请号：US399175

申请日：1982-07-16

申请人： Harvey Rubin

发明人： Harvey Rubin

IPC分类号： H04M3/30 ,  H04J3/14 ,  H04M3/22

CPC分类号： H04M3/30

摘要： A mechanized system distributing the access, test and communication functions to the point of testing, typically the centralized switching facility serving the telephone loops and equipment to be tested. Computer (200) stores information about each subscriber loop in the geographical area served by a system. Front-end computers (220,221) interact with computer (200) to retrieve pertinent data regarding loops to be tested. Each switching facility in an area includes a loop testing system (e.g., 160) that implements the required functions. The communication functions residing in front-end computers (220,221) and loop testing systems (160,161) are coupled via a data communication network (140) in a manner that allows any front-end computer to communicate with any loop testing system. Users of the system control access and test from consoles having the capability of establishing independent communication paths over the national dial network for interactive tests on loops accessed through standard test trunks. Microprocessor-based circuitry is utilized for numerous system tasks such as signal generation, digital signal processing and controlling sensitive analog measurements. Signal generation includes digital generation of analog waveforms. Signal processing techniques incorporate various digital filters to analyze sample sequences derived from, for example, dial pulses and coin telephone signals. Sensitive analog measurements of loop characteristics are effected with a magnetic current detector that operates over broad current and frequency ranges. Frequency dependent measurements are converted to DC using synchronous demodulation techniques to enhance resolution.

摘要翻译： 将访问，测试和通信功能分配到测试点的机械化系统，通常是服务于要测试的电话回路和设备的集中式交换设施。 计算机（200）存储关于由系统服务的地理区域中的每个用户环路的信息。 前端计算机（220,221）与计算机（200）进行交互以检索关于要测试的循环的相关数据。 区域中的每个切换设备包括实现所需功能的环路测试系统（例如，160）。 驻留在前端计算机（220,221）和环路测试系统（160,161）中的通信功能通过数据通信网络（140）以允许任何前端计算机与任何环路测试系统通信的方式耦合。 系统的用户控制访问和测试，具有通过国家拨号网络建立独立通信路径的能力，以便通过标准测试中继线访问的环路进行交互式测试。 基于微处理器的电路用于许多系统任务，例如信号生成，数字信号处理和控制敏感的模拟测量。 信号发生包括模拟波形的数字生成。 信号处理技术包括各种数字滤波器以分析从例如拨号脉冲和硬币电话信号导出的样本序列。 使用在宽电流和频率范围内工作的磁流检测器实现环路特性的敏感模拟测量。 使用同步解调技术将频率相关测量值转换为直流，以增强分辨率。

公开(公告)号：US4568640A

公开(公告)日：1986-02-04

申请号：US476925

申请日：1983-03-21

申请人： Harvey Rubin

发明人： Harvey Rubin

IPC分类号： C07K14/00 ,  C07K14/675 ,  C12N15/00 ,  C12P21/02

CPC分类号： C07K14/00 ,  C07K14/675 ,  C12N15/00 ,  Y10S530/808

摘要： A method for substituting one amino acid for another in a protein chain to improve selected properties of the protein. Initially, an mRNA molecule capable of producing an unmodified protein of the type it is desired to modify is provided. Next the codon along the mRNA chain which ordinarily accepts the anti-codon corresponding to a first amino acid which is to be replaced with a selected second amino acid is determined. The tRNA which ordinarily brings the first amino acid to that site is modified to carry the second amino acid instead. The modified protein is then formed by translation techniques in the presence of the modified tRNA, whereby the second amino acid is incorporated in the protein chain in place of the first amino acid. Several methods of accomplishing the modification of the selected tRNA are also disclosed.

摘要翻译： 在蛋白质链中用一个氨基酸取代另一个的方法来改善蛋白质的选择性质。 首先，提供能够产生希望修饰类型的未修饰蛋白质的mRNA分子。 接下来，确定通常接受与被选择的第二氨基酸替代的第一个氨基酸相对应的抗密码子的mRNA链上的密码子。 通常将第一个氨基酸带到该位点的tRNA被修饰以携带第二个氨基酸。 然后通过翻译技术在修饰的tRNA的存在下形成修饰的蛋白质，由此将第二个氨基酸并入蛋白质链中代替第一个氨基酸。 还公开了完成所选tRNA修饰的几种方法。

公开(公告)号：US4525789A

公开(公告)日：1985-06-25

申请号：US399184

申请日：1982-07-16

申请人： Kyran B. Kemper ,  Harvey Rubin

发明人： Kyran B. Kemper ,  Harvey Rubin

IPC分类号： H04M3/30 ,  G06F15/20 ,  G01R15/12 ,  H03G3/30

CPC分类号： H04M3/30

摘要： A mechanized system distributing the access, test and communication functions to the point of testing, typically the centralized switching facility serving the telephone loops and equipment to be tested. Computer (200) stores information about each subscriber loop in the geographical area served by a system. Front-end computers (220,221) interact with computer (200) to retrieve pertinent data regarding loops to be tested. Each switching facility in an area includes a loop testing system (e.g., 160) that implements the required functions. The communication functions residing in front-end computers (220,221) and loop testing systems (160,161) are coupled via a data communication network (140) in a manner that allows any front-end computer to communicate with any loop testing system. Users of the system control access and test from consoles having the capability of establishing independent communication paths over the national dial network for interactive tests on loops accessed through standard test trunks. Microprocessor-based circuitry is utilized for numerous system tasks such as signal generation, digital signal processing and controlling sensitive analog measurements. Signal generation includes digital generation of analog waveforms. Signal processing techniques incorporate various digital filters to analyze sample sequences derived from, for example, dial pulses and coin telephone signals. Sensitive analog measurements of loop characteristics are effected with a magnetic current detector that operates over broad current and frequency ranges. Frequency dependent measurements are converted to DC using synchronous demodulation techniques to enhance resolution.

摘要翻译： 将访问，测试和通信功能分配到测试点的机械化系统，通常是服务于要测试的电话回路和设备的集中式交换设施。 计算机（200）存储关于由系统服务的地理区域中的每个用户环路的信息。 前端计算机（220,221）与计算机（200）进行交互以检索关于要测试的循环的相关数据。 区域中的每个切换设备包括实现所需功能的环路测试系统（例如，160）。 驻留在前端计算机（220,221）和环路测试系统（160,161）中的通信功能通过数据通信网络（140）以允许任何前端计算机与任何环路测试系统通信的方式耦合。 系统的用户控制访问和测试，具有通过国家拨号网络建立独立通信路径的能力，以便通过标准测试中继线访问的环路进行交互式测试。 基于微处理器的电路用于许多系统任务，例如信号生成，数字信号处理和控制敏感的模拟测量。 信号发生包括模拟波形的数字生成。 信号处理技术包括各种数字滤波器以分析从例如拨号脉冲和硬币电话信号导出的样本序列。 使用在宽电流和频率范围内工作的磁流检测器实现环路特性的敏感模拟测量。 使用同步解调技术将频率相关测量值转换为直流，以增强分辨率。

公开(公告)号：US4467147A

公开(公告)日：1984-08-21

申请号：US399188

申请日：1982-07-16

申请人： Harvey Rubin

发明人： Harvey Rubin

IPC分类号： H04M3/30 ,  H04M3/24

CPC分类号： H04M3/30

摘要： A mechanized system distributing the access, test and communication functions to the point of testing, typically the centralized switching facility serving the telephone loops and equipment to be tested. Computer (200) stores information about each subscriber loop in the geographical area served by a system. Front-end computers (220,221) interact with computer (200) to retrieve pertinent data regarding loops to be tested. Each switching facility in an area includes a loop testing system (e.g., 160) that implements the required functions. The communication functions residing in front-end computers (220,221) and loop testing systems (160,161) are coupled via a data communication network (140) in a manner that allows any front-end computer to communicate with any loop testing system. Users of the system control access and test from consoles having the capability of establishing independent communication paths over the national dial network for interactive tests on loops accessed through standard test trunks. Microprocessor-based circuitry is utilized for numerous system tasks such as signal generation, digital signal processing and controlling sensitive analog measurements. Signal generation includes digital generation of analog waveforms. Signal processing techniques incorporate various digital filters to analyze sample sequences derived from, for example, dial pulses and coin telephone signals. Sensitive analog measurements of loop characteristics are effected with a magnetic current detector that operates over broad current and frequency ranges. Frequency dependent measurements are converted to DC using synchronous demodulation techniques to enhance resolution.

摘要翻译： 将访问，测试和通信功能分配到测试点的机械化系统，通常是服务于要测试的电话回路和设备的集中式交换设施。 计算机（200）存储关于由系统服务的地理区域中的每个用户环路的信息。 前端计算机（220,221）与计算机（200）进行交互以检索关于要测试的循环的相关数据。 区域中的每个切换设备包括实现所需功能的环路测试系统（例如，160）。 驻留在前端计算机（220,221）和环路测试系统（160,161）中的通信功能通过数据通信网络（140）以允许任何前端计算机与任何环路测试系统通信的方式耦合。 系统的用户控制访问和测试，具有通过国家拨号网络建立独立通信路径的能力，以便通过标准测试中继线访问的环路进行交互式测试。 基于微处理器的电路用于许多系统任务，例如信号生成，数字信号处理和控制敏感的模拟测量。 信号发生包括模拟波形的数字生成。 信号处理技术包括各种数字滤波器以分析从例如拨号脉冲和硬币电话信号导出的样本序列。 使用在宽电流和频率范围内工作的磁流检测器实现环路特性的敏感模拟测量。 使用同步解调技术将频率相关测量值转换为直流，以增强分辨率。