公开(公告)号：US06995162B2

公开(公告)日：2006-02-07

申请号：US10046681

申请日：2002-01-10

申请人： Guoqing Chen ,  Jeffrey Adams ,  Jean Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian Di Pietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael Croghan

发明人： Guoqing Chen ,  Jeffrey Adams ,  Jean Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian Di Pietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael Croghan

IPC分类号： A61K31/435 ,  C07D213/82

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US06864255B2

公开(公告)日：2005-03-08

申请号：US10120939

申请日：2002-04-10

申请人： Stephanie D. Geuns-Meyer ,  Lucian V. DiPietro ,  Joseph L. Kim ,  Vinod F. Patel

发明人： Stephanie D. Geuns-Meyer ,  Lucian V. DiPietro ,  Joseph L. Kim ,  Vinod F. Patel

IPC分类号： A61P35/00 ,  C07D251/18 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/14 ,  C07D251/16 ,  A61K31/53

CPC分类号： C07D401/04 ,  C07D251/18 ,  C07D401/14 ,  C07D403/04 ,  C07D417/14

摘要： The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and angiogenesis-related disease.

摘要翻译： 本发明包括其化合物，类似物，前药和药学上可接受的盐，药物组合物，用于预防和治疗癌症和血管发生相关疾病的用途和方法。