专利检索 ap:"Julie Germain" 第 1 页

1.

发明授权
Method of treating cancer with substituted amide derivatives 有权
标题翻译：用取代酰胺衍生物治疗癌症的方法

公开(公告)号：US08685983B2

公开(公告)日：2014-04-01

申请号：US13308310

申请日：2011-11-30

申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang

发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang

IPC分类号： A61K31/497 , A61K31/5377 , A61K31/437 , A61K31/519 , A61K31/4184 , A61K31/501 , A61K31/4709 , A61K31/4365

CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

2.

发明申请
METHOD OF TREATING CANCER WITH SUBSTITUTED AMIDE DERIVATIVES 有权
标题翻译：用替代酰胺衍生物治疗癌症的方法

公开(公告)号：US20120070413A1

公开(公告)日：2012-03-22

申请号：US13308310

申请日：2011-11-30

申请人： Tae-Seong KIM , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang

发明人： Tae-Seong KIM , David Bauer , Steven Bellon , Alessadro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang

IPC分类号： A61K38/21 , A61K31/497 , A61K31/5377 , A61P35/00 , A61K31/437 , A61K31/519 , A61K31/4184 , A61K31/501 , A61K31/4709 , A61K31/4365

CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

3.

发明申请
Compounds and methods of use 有权

公开(公告)号：US20090176774A1

公开(公告)日：2009-07-09

申请号：US12157303

申请日：2008-06-09

申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La

发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La

IPC分类号： A61K31/536 , A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709

CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

4.

发明申请
Substituted alkylamine derivatives and methods of use 有权

公开(公告)号：US20060040956A1

公开(公告)日：2006-02-23

申请号：US11234713

申请日：2005-09-23

申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan

发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan

IPC分类号： A61K31/506 , C07D403/02

CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

5.

发明申请
Substituted alkylamine derivatives and methods of use 失效
标题翻译：取代的烷基胺衍生物和使用方法

公开(公告)号：US20050261313A1

公开(公告)日：2005-11-24

申请号：US11014184

申请日：2004-12-15

申请人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian DiPietro , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Gregory Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Babak Riahi , Joseph Kim , Ning Xi , Kevin Yang , Chester Yuan

发明人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian DiPietro , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Gregory Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Babak Riahi , Joseph Kim , Ning Xi , Kevin Yang , Chester Yuan

IPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P9/10 , A61P11/06 , A61P15/08 , A61P17/06 , A61P19/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/02 , C07D471/04 , C07D491/02 , C07D41/02 , C07D43/02

CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

6.

发明申请
SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE 有权
标题翻译：取代的烷基胺衍生物及其使用方法

公开(公告)号：US20120065185A1

公开(公告)日：2012-03-15

申请号：US13297213

申请日：2011-11-15

申请人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan

发明人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan

IPC分类号： A61K31/4436 , A61K31/4709 , A61K31/4725 , A61P3/00 , A61P7/00 , A61P35/00 , A61P31/00 , A61K31/444 , A61K31/5377

CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.

摘要翻译： 所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。

7.

发明授权
Substituted amide derivatives and methods of use 有权
标题翻译：取代的酰胺衍生物和使用方法

公开(公告)号：US08088794B2

公开(公告)日：2012-01-03

申请号：US12945575

申请日：2010-11-12

申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang

发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang

IPC分类号： A61K31/47 , C07D453/02

CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

8.

发明授权
Heterocyclic compounds and methods of use 有权
标题翻译：杂环化合物和使用方法

公开(公告)号：US07531553B2

公开(公告)日：2009-05-12

申请号：US10804915

申请日：2004-03-19

申请人： Lucian V. Di Pietro , Jean-Christophe Harmange , Benny C. Askew, Jr. , Daniel Elbaum , Julie Germain , Gregory J. Habgood , Joseph L. Kim , Vinod F. Patel , Michele Potashman , Simon van der Plas

发明人： Lucian V. Di Pietro , Jean-Christophe Harmange , Benny C. Askew, Jr. , Daniel Elbaum , Julie Germain , Gregory J. Habgood , Joseph L. Kim , Vinod F. Patel , Michele Potashman , Simon van der Plas

IPC分类号： A61K31/47 , C07D215/00

CPC分类号： C07D401/12 , C07D235/30 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。