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230 条记录 (耗时 0.027 秒)

    Preparation of tetraalkylthiuram disulfides
    52.
    发明授权
    Preparation of tetraalkylthiuram disulfides 失效
    四烷基秋兰姆二硫化物的制备

    公开(公告)号：US4148697A

    公开(公告)日：1979-04-10

    申请号：US874177

    申请日：1978-02-01

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

    IPC分类号： C25B3/10 ,  C07C67/00 ,  C07C325/00 ,  C07C333/16 ,  C07C333/32 ,  C25B3/02 ,  C07C155/10

    CPC分类号： C07C333/16

    摘要： A tetraalkylthiuram disulfide is prepared in a higher yield without formation of by-products by subjecting the corresponding alkali metal dialkyldithiocarbamate to electrolytic oxidation, which is carried out in a two-layer electrolytic solution consisting essentially of either (1) water and carbon disulfide or (2) water and a mixture of carbon disulfide and a halogenated alkane of higher density than water, the carbon disulfide being predominant in the mixture, by means of electrodes placed in the aqueous layer containing the dialkyldithiocarbamate. The resulting disulfide is extracted to the lower layer of the electrolytic solution and is recovered from the layer. The dialkyldithiodicarbamate can be continuously produced in situ by adding carbon disulfide and dialkylamine gradually to the aqueous layer of the electrolytic solution, which contains an alkalimetal hydroxide produced during the electrolytic oxidation of the dialkyldithiocarbamate.

    摘要翻译： 通过使相应的二烷基二硫代氨基甲酸碱金属二烷基二硫代氨基甲酸盐进行电解氧化，可以以较高的产率制备四烷基秋兰姆二硫化物而不形成副产物，该电解氧化基本上由（1）水和二硫化碳组成的双层电解质溶液或（ 2）水和二硫化碳与卤化烷烃的混合物比水密度高，二硫化碳在混合物中占优势，借助放置在含二烷基二硫代氨基甲酸二烷基酯的水层中的电极。 将得到的二硫化物萃取到电解液的下层，并从层中回收。 二烷基二硫代氨基甲酸二烷基酯可以通过在二烷基二硫代氨基甲酸酯的电解氧化中产生的含有碱金属氢氧化物的电解液的水层中逐渐加入二硫化碳和二烷基胺而原位连续生产。

    Preparation of benzothiazolylsulfenamides
    53.
    发明授权
    Preparation of benzothiazolylsulfenamides 失效
    苯并噻唑亚磺酰胺的制备

    公开(公告)号：US4127454A

    公开(公告)日：1978-11-28

    申请号：US826794

    申请日：1977-08-22

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Masashi Ukida

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Masashi Ukida

    IPC分类号： C07D277/80 ,  C25B3/10 ,  C25B3/02 ,  C07D277/60

    CPC分类号： C07D277/80

    摘要： Benzothiazolylsulfenamides are prepared in a high yield and substantially without a side reaction, via direct electrolytic oxidation, by cross-coupling (1) 2-mercaptobenzothiazole or dibenzothiazyl disulfide or an alkali metal salt of 2-mercaptobenzothiazole with (2) a primary or secondary amine, in the presence of a solvent selected from a dipolar aprotic solvent, a protic solvent, water and mixtures thereof, as well as a supporting electrolyte having adaptability to the solvent.

    摘要翻译： 通过直接电解氧化，通过交联（1）2-巯基苯并噻唑或二苯并噻唑二硫化物或2-巯基苯并噻唑的碱金属盐与（2）伯胺或仲胺反应制备苯并噻唑亚磺酰胺 在选自偶极非质子溶剂，质子溶剂，水及其混合物的溶剂的存在下，以及对溶剂具有适应性的支持电解质。

    2 .beta.-substituted thiomethylpenicillin derivatives and their preparation and use
    55.
    发明授权
    2 .beta.-substituted thiomethylpenicillin derivatives and their preparation and use 失效
    2β-取代的硫代甲基青霉素衍生物及其制备和用途

    公开(公告)号：US4861768A

    公开(公告)日：1989-08-29

    申请号：US16114

    申请日：1987-02-18

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Motoaki Tanaka ,  Shozo Yamada ,  Akira Nakai ,  Hisashi Ohbayashi

    IPC分类号： C07D499/00 ,  C07D499/86

    CPC分类号： C07D499/00

    摘要： Disclosed is a penicillin derivative of the formula: ##STR1## wherein n is an integer of 0, 1 or 2; Y is a cyano group, a lower acyl group, a mono- or di-lower alkylthiocarbamoyl group, ##STR2## wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a phenyl group, a group --(CH.sub.2).sub.m --OR.sub.2 or --(CH.sub.2).sub.m COOR.sub.2 (m is an integer of 1 to 6 and R.sub.2 is a hydrogen atom or a penicillin carboxyl ester-forming group which is commonly used for penicillin derivatives) or a phenyl group substituted by at least one member selected from the class consisting of lower alkyl group, halogen atom and lower alkoxy group; and R is a hydrogen atom or a penicillin carboxyl ester-forming group, or a salt thereof. They are useful as .beta.-lactamase inhibitors.

    摘要翻译： 公开了下式的青霉素衍生物：其中n是0,1或2的整数; Y是氰基，低级酰基，单 - 或二 - 低级烷硫基氨基甲酰基，其中R1是氢原子，低级烷基，苯基，基 - （CH2）m-OR2或 - （CH 2）m COOR 2（m为1〜6的整数，R2为氢原子或青霉素衍生物通常使用的青霉素羧酸酯形成基）或被选自上述的至少一种的苯基 由低级烷基，卤素原子和低级烷氧基组成; 和R是氢原子或青霉素羧酸酯形成基团或其盐。 它们可用作β-内酰胺酶抑制剂。

    Cyclopentanol derivatives
    57.
    发明授权
    Cyclopentanol derivatives 失效
    环戊醇衍生物

    公开(公告)号：US4173707A

    公开(公告)日：1979-11-06

    申请号：US913689

    申请日：1978-06-08

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Yuichi Kobayashi

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Yuichi Kobayashi

    IPC分类号： C07C67/30 ,  C07C69/74 ,  C07C69/757

    摘要： A cyclopentanol derivative represented by the formula ##STR1## wherein R.sub.1 and R.sub.2 are lower straight-chain or branched-chain alkyl, alkenyl or aralkyl, and R.sub.4 is 2-pentenyl or 2-pentynyl, and process for preparing the same.

    摘要翻译： 由下式表示的环戊醇衍生物，其中R 1和R 2为低级直链或支链烷基，烯基或芳烷基，R 4为2-戊烯基或2-戊炔基，及其制备方法。

    Process for producing exo-methylenepenam compounds
    58.
    发明授权
    Process for producing exo-methylenepenam compounds 失效
    生产外亚甲基山梨醇化合物的方法

    公开(公告)号：US06339152B1

    公开(公告)日：2002-01-15

    申请号：US09380582

    申请日：1999-09-07

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Yutaka Kameyama ,  Yoshihisa Tokumaru

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Yutaka Kameyama ,  Yoshihisa Tokumaru

    IPC分类号： C07D49987

    CPC分类号： C07D499/00 ,  Y02P20/55

    摘要： The present invention is directed to a process for preparing an exo-methylenepenam compound wherein a cephem compound is reduced with a metal having a standard oxidation-reduction potential of up to −0.3 (V/SCE) in an amount of at least one mole per mole of the cephem compound and with a metal compound having a higher standard oxidation reduction potential than the metal and in an amount of 0.001 to 10 moles per mole of the cephem compound and wherein X is a halogen atom, lower alkylsulfonyloxy, trifluoromethanesulfonyloxy, trichloromethanesulfonyloxy, arylsulfonyloxy, toluenesulfonyloxy, or halogenated sulfonyloxy

    摘要翻译： 本发明涉及一种制备外亚甲基环戊二烯化合物的方法，其中头孢烯化合物以至少为1摩尔量的标准氧化还原电位高达-0.3（V / SCE）的金属还原 和具有比金属高的标准氧化还原电位的金属化合物，并且每摩尔头孢烯化合物的量为0.001至10摩尔，其中X为卤素原子，低级烷基磺酰氧基，三氟甲磺酰氧基，三氯甲磺酰氧基， 芳基磺酰氧基，甲苯磺酰氧基或卤代磺酰氧基

    Process for producing a tetraalkylthiuram disulfide
    60.
    发明授权
    Process for producing a tetraalkylthiuram disulfide 失效
    生产四烷基秋兰姆二硫化物的方法

    公开(公告)号：US4120764A

    公开(公告)日：1978-10-17

    申请号：US869409

    申请日：1978-01-16

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Kiyoshi Mishima

    IPC分类号： C25B3/02 ,  C07C155/10

    CPC分类号： C25B3/02

    摘要： A process for producing a tetraalkylthiuram disulfide which comprises electrolytically oxidizing a dialkylammonium dialkyldithiocarbamate having the formula ##STR1## wherein each R represents an alkyl group having from 1 to 4 carbon atoms, in the presence or absence of a supporting electrolyte to produce a tetraalkylthiuram disulfide, the electrolytic oxidation being carried out in one or more solvents which dissolve at least one of the starting dialkylammonium dialkyldithiocarbamate and the resulting tetraalkylthiuram disulfide.

    摘要翻译： 一种生产四烷基秋兰姆二硫化物的方法，其包括电解氧化具有式“IMAGE”的二烷基二烷基二硫代氨基甲酸二烷基铵，其中每个R表示具有1至4个碳原子的烷基，在存在或不存在支持电解质的情况下，产生四烷基秋兰姆二硫化物， 电解氧化在一种或多种溶剂中进行，所述溶剂溶解起始二烷基二烷基二硫代氨基甲酸烷基酯和所得的四烷基秋兰姆二硫化物中的至少一种。