公开(公告)号：US4058616A

公开(公告)日：1977-11-15

申请号：US692325

申请日：1976-06-03

申请人： Werner Kummer ,  Helmut Stahle ,  Herbert Koppe ,  Walter Haarmann ,  Richard Reichl

发明人： Werner Kummer ,  Helmut Stahle ,  Herbert Koppe ,  Walter Haarmann ,  Richard Reichl

IPC分类号： A61K31/415 ,  A61P7/02 ,  C07D233/48 ,  A61K31/445 ,  C07D401/14

CPC分类号： C07D233/48 ,  Y10S514/822

摘要： A compound of the formula ##STR1## wherein R.sub.1 is chlorine, bromine, fluorine or methyl;R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, chlorine or methyl;R.sub.4 is hydrogen, methyl or ethyl; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each methyl, ethyl or alkoxy-alkyl of 2 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocycle which may contain an additional heteroatom, such as pyrrolidino, piperidino, morpholino, piperazino or hexamethyleneimino;And non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as the salts are useful as antithrombotics.

摘要翻译： 其中R 1是氯，溴，氟或甲基的式（Ⅰ）化合物; R2和R3可以相同或不同，分别为氢，氯或甲基; R4是氢，甲基或乙基; 和可以相同或不同的R 5和R 6各自是2至4个碳原子的甲基，乙基或烷氧基 - 烷基，或彼此连接并与它们相连的氮原子形成5 - 可含有另外的杂原子的6-或7-元杂环，例如吡咯烷子基，哌啶子基，吗啉代，哌嗪基或六亚甲基亚氨基; 和非毒性药用植物酸加药盐; 化合物作为抗菌药物有用的方法。