公开(公告)号：US20070203527A1

公开(公告)日：2007-08-30

申请号：US11724899

申请日：2007-03-16

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/36 ,  A61B5/0464

CPC分类号： A61B5/0215 ,  A61B5/0464 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/3621

摘要： Apparatus is provided, which includes an electrode device, configured to be coupled to an atrial site of a subject containing parasympathetic nervous tissue, and a control unit. The control unit is configured to, responsively to a detection of an episode of non-sinus atrial tachycardia, restore normal sinus rhythm (NSR) of the subject, by driving the electrode device to apply a parasympathetic stimulation signal to the atrial site, and configuring the parasympathetic stimulation signal to activate the parasympathetic nervous tissue sufficiently to restore the NSR. Other embodiments are also described.

摘要翻译： 提供了包括电极装置的装置，其被配置为耦合到包含副交感神经组织的受试者的心房部位和控制单元。 控制单元被配置为响应于检测到非窦房性心动过速的发作，通过驱动电极装置将副交感神经刺激信号施加到心房部位来恢复受试者的正常窦性心律（NSR），并且配置 副交感神经刺激信号激活副交感神经组织足以恢复NSR。 还描述了其它实施例。

公开(公告)号：US08204591B2

公开(公告)日：2012-06-19

申请号：US11657784

申请日：2007-01-24

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/36

CPC分类号： A61N1/3962 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395

摘要： A method is provided, including identifying that a subject is at risk of suffering from atrial fibrillation (AF). Responsively to the identifying, a risk of an occurrence of an episode of the AF is reduced by applying an electrical current to a site of the subject selected from the group consisting of: a vagus nerve, a sinoatrial (SA) node fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a jugular vein, an azygos vein, an innominate vein, and a subclavian vein, and configuring the current to stimulate autonomic nervous tissue in the site. Other embodiments are also described.

摘要翻译： 提供了一种方法，包括识别受试者处于心房颤动（AF）的风险。 响应于识别，通过向选自以下的组中的受试者的位点施加电流来减少AF的发作的风险：迷走神经，窦房（SA）节点脂肪垫， 肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉，颈静脉，纯合静脉，无名静脉和锁骨下静脉，并配置电流以刺激部位的自主神经组织。 还描述了其它实施例。

公开(公告)号：US07908008B2

公开(公告)日：2011-03-15

申请号：US11977646

申请日：2007-10-24

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/18

CPC分类号： A61N1/0556 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A treatment method is provided, including identifying a subject as one who is selected to undergo an interventional medical procedure, and, in response to the identifying, reducing a likelihood of a potential adverse effect of the procedure by applying an electrical current to a parasympathetic site of the subject selected from the group consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a jugular vein of the subject, a right ventricle of the subject, a parasympathetic ganglion of the subject, and a parasympathetic nerve of the subject.

摘要翻译： 提供了一种治疗方法，包括将受试者识别为被选择进行介入医疗程序的受试者，并且响应于鉴定，通过将电流施加到副交感神经部位来减少手术的潜在不利影响的可能性 所述对象选自：受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，受试者的颈动脉，受试者的颈动脉窦，冠状窦 受试者，受试者的静脉静脉，受试者的颈静脉，受试者的右心室，受试者的副交感神经节和受试者的副交感神经。

公开(公告)号：US07885711B2

公开(公告)日：2011-02-08

申请号：US10560654

申请日：2004-06-10

申请人： Omry Ben-Ezra ,  Ehud Cohen ,  Tamir Ben-David

发明人： Omry Ben-Ezra ,  Ehud Cohen ,  Tamir Ben-David

IPC分类号： A61N1/362

CPC分类号： A61N1/0556 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： Apparatus (20) for treating a subject (30) suffering from spontaneous atrial fibrillation includes an electrode device (22), adapted to be coupled to a site of the subject (30) selected from the list consisting of: a vagus nerve (24) of the subject (30), an epicardial fat pad of the subject (30), a pulmonary vein of the subject (30), a carotid artery of the subject (30), a carotid sinus of the subject (30), a vena cava vein of the subject (30), and an internal jugular vein of the subject (30), and a control unit (32), adapted to drive the electrode device (22) to apply an electrical current to the site, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.

摘要翻译： 用于治疗患有自发性心房颤动的受试者（30）的装置（20）包括电极装置（22），其适于耦合到选自以下的列表中的受试者（30）的位置：迷走神经（24） 受试者（30）的心外膜脂肪垫，受试者（30）的肺静脉，受试者（30）的颈动脉，受试者（30）的颈动脉窦，体外 受试者（30）的静脉和静脉内部的颈内静脉和控制单元（32），其适于驱动电极装置（22）向该部位施加电流，并且配置 目前为了维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

公开(公告)号：US20080125819A1

公开(公告)日：2008-05-29

申请号：US11975241

申请日：2007-10-17

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.

摘要翻译： 提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。 该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎， 包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合 结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

公开(公告)号：US20080119898A1

公开(公告)日：2008-05-22

申请号：US11977923

申请日：2007-10-25

申请人： Tamir Ben-David ,  Nitza Gal-on Shoham ,  Ehud Cohen ,  Rami Biran ,  Omry Ben-Ezra

发明人： Tamir Ben-David ,  Nitza Gal-on Shoham ,  Ehud Cohen ,  Rami Biran ,  Omry Ben-Ezra

IPC分类号： A61N1/00

CPC分类号： A61N1/0556 ,  A61N1/205 ,  A61N1/36114

摘要： Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.

摘要翻译： 提供了用于治疗受试者的状况的装置，包括适于与被检体的自主神经联接的电极装置，以及控制单元。 所述控制单元适于驱动所述电极装置向所述神经施加刺激电流，所述刺激电流能够诱导所述神经的第一组和第二组神经纤维中的治疗方向的动作电位，并驱动所述电极 能够抑制在第二组神经纤维中沿治疗方向行进的诱导作用电位的神经抑制电流的装置，第二组神经纤维中的神经纤维的直径通常大于第一组神经纤维中的神经纤维的直径 组。 还描述了其它实施例。

公开(公告)号：US07239988B2

公开(公告)日：2007-07-03

申请号：US10469994

申请日：2002-03-19

申请人： Assaf Hasson ,  Amir Beker ,  Tamir Ben-David

发明人： Assaf Hasson ,  Amir Beker ,  Tamir Ben-David

IPC分类号： G06F17/10

CPC分类号： A61B5/0452 ,  A61B5/044 ,  A61B5/4884 ,  A61B5/7232 ,  G06F17/14

摘要： Apparatus for graphically representing a substantially periodic signal having substantially periodic segments, comprising a graphic transformer for converting the periodic segments into encodings respectively for arrangement in a first dimension and successively indexing the encodings to form a two-dimensional coded image, thereby to represent, within the image, dynamic changes of the periodic segments over the signal.

摘要翻译： 用于图形地表示具有基本上周期性段的基本上周期性信号的装置，包括图形变换器，用于将周期性段转换成编码，分别用于在第一维度中排列并连续索引编码以形成二维编码图像，从而在 图像，周期性片段在信号上的动态变化。

公开(公告)号：US08731651B2

公开(公告)日：2014-05-20

申请号：US13540791

申请日：2012-07-03

申请人： Gal Ben-David ,  Tamir Ben-David ,  Ilan Calderon

发明人： Gal Ben-David ,  Tamir Ben-David ,  Ilan Calderon

IPC分类号： A61B5/04

CPC分类号： A61N1/36014 ,  A61M5/1723 ,  A61M2210/1433

摘要： A method and system for regulating uterine muscular activity including measuring uterine contraction with an electrical uterine monitor (EUM), and using sensed measurements of the uterine contraction to regulate uterine muscular activity by comparing the sensed measurements to a desired level, wherein the difference between sensed and desired level is used to calculate the level of either manual or automatic application of drugs or electrical signals.

摘要翻译： 一种用于调节子宫肌肉活动的方法和系统，包括用电子宫监视器（EUM）测量子宫收缩，并且通过将感测到的测量值与期望的水平进行比较来使用子宫收缩的感测测量来调节子宫肌肉活动，其中感测到的差异 并且使用期望的水平来计算手动或自动应用药物或电信号的水平。

公开(公告)号：US20140012190A1

公开(公告)日：2014-01-09

申请号：US13540791

申请日：2012-07-03

申请人： Gal Ben-David ,  Tamir Ben-David ,  Ilan Calderon

发明人： Gal Ben-David ,  Tamir Ben-David ,  Ilan Calderon

IPC分类号： A61M5/168 ,  A61N1/36

CPC分类号： A61N1/36014 ,  A61M5/1723 ,  A61M2210/1433

摘要： A method and system for regulating uterine muscular activity including measuring uterine contraction with an electrical uterine monitor (EUM), and using sensed measurements of the uterine contraction to regulate uterine muscular activity by comparing the sensed measurements to a desired level, wherein the difference between sensed and desired level is used to calculate the level of either manual or automatic application of drugs or electrical signals.

摘要翻译： 一种用于调节子宫肌肉活动的方法和系统，包括用电子宫监视器（EUM）测量子宫收缩，并且通过将感测到的测量值与期望的水平进行比较来使用子宫收缩的感测测量来调节子宫肌肉活动，其中感测到的差异 并且使用期望的水平来计算手动或自动应用药物或电信号的水平。

公开(公告)号：US07885709B2

公开(公告)日：2011-02-08

申请号：US11234877

申请日：2005-09-22

申请人： Tamir Ben-David

发明人： Tamir Ben-David

IPC分类号： A61N1/36

CPC分类号： A61N1/36071 ,  A61N1/36114

摘要： This invention provides a method for treating a condition of a subject, comprising identifying the subject as suffering from heart failure; treating the heart failure by applying a stimulating current to parasympathetic nervous tissue of the subject, and configuring the stimulating current to change a level of protein expression of at least one NO synthase of the subject selected from the group consisting of: NOS-1, NOS-2, and NOS-3; and thereafter, measuring the level of the protein expression of at least one NO synthase, and evaluating an effectiveness of the current application by assessing at least one change in the level of the protein expression of at least one NO synthase.

摘要翻译： 本发明提供了一种治疗受试者状况的方法，包括鉴定受试者患有心力衰竭; 通过对受试者的副交感神经组织施加刺激电流来治疗心力衰竭，以及配置刺激电流以改变选自下组的至少一种NO合酶的蛋白质表达水平：NOS-1，NOS -2和NOS-3; 然后测定至少一种NO合成酶的蛋白质表达水平，并通过评估至少一种NO合成酶的蛋白质表达水平的至少一个变化来评估当前应用的有效性。