公开(公告)号：US20120303080A1

公开(公告)日：2012-11-29

申请号：US13493499

申请日：2012-06-11

申请人： Tamir BEN-DAVID ,  Omry BEN-EZRA ,  Ehud COHEN

发明人： Tamir BEN-DAVID ,  Omry BEN-EZRA ,  Ehud COHEN

IPC分类号： A61N1/365 ,  A61N1/05

CPC分类号： A61N1/3962 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395

摘要： A method is provided, including identifying that a subject is at risk of suffering from atrial fibrillation (AF). Responsively to the identifying, a risk of an occurrence of an episode of the AF is reduced by coupling an electrode device to a site of a subject containing parasympathetic nervous tissue; driving, by a control unit, the electrode device to apply an electrical current to the site not responsively to any physiological parameters sensed by any device directly or indirectly coupled to the control unit; and configuring the current to stimulate autonomic nervous tissue in the site. Other embodiments are also described.

摘要翻译： 提供了一种方法，包括确定受试者处于心房颤动（AF）的风险。 响应于鉴定，通过将电极装置耦合到包含副交感神经组织的受试者的部位来降低发生AF发作的风险; 通过控制单元驱动电极装置，以不响应于直接或间接地耦合到控制单元的任何装置感测到的任何生理参数来施加电流到现场; 并配置电流以刺激现场的自主神经组织。 还描述了其它实施例。

公开(公告)号：US08224444B2

公开(公告)日：2012-07-17

申请号：US11975654

申请日：2007-10-19

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen ,  Shai Ayal

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen ,  Shai Ayal

IPC分类号： A61N1/00

CPC分类号： A61N1/36114

摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.

摘要翻译： 提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间 ，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。 还描述了其它实施例。

公开(公告)号：US08204591B2

公开(公告)日：2012-06-19

申请号：US11657784

申请日：2007-01-24

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/36

CPC分类号： A61N1/3962 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395

摘要： A method is provided, including identifying that a subject is at risk of suffering from atrial fibrillation (AF). Responsively to the identifying, a risk of an occurrence of an episode of the AF is reduced by applying an electrical current to a site of the subject selected from the group consisting of: a vagus nerve, a sinoatrial (SA) node fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a jugular vein, an azygos vein, an innominate vein, and a subclavian vein, and configuring the current to stimulate autonomic nervous tissue in the site. Other embodiments are also described.

摘要翻译： 提供了一种方法，包括识别受试者处于心房颤动（AF）的风险。 响应于识别，通过向选自以下的组中的受试者的位点施加电流来减少AF的发作的风险：迷走神经，窦房（SA）节点脂肪垫， 肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉，颈静脉，纯合静脉，无名静脉和锁骨下静脉，并配置电流以刺激部位的自主神经组织。 还描述了其它实施例。

公开(公告)号：US20110137365A1

公开(公告)日：2011-06-09

申请号：US13022199

申请日：2011-02-07

申请人： Omry BEN-EZRA ,  Tamir BEN-DAVID ,  Ehud COHEN

发明人： Omry BEN-EZRA ,  Tamir BEN-DAVID ,  Ehud COHEN

IPC分类号： A61N1/365 ,  A61N1/36 ,  A61N1/362 ,  A61N1/00

CPC分类号： A61N1/36071 ,  A61N1/36114

摘要： Apparatus is provided including an electrode device and a control unit. The electrode device is configured to be coupled to a site of a subject selected from the group consisting of: a vagus nerve, an epicardial fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a right ventricle, a right atrium, and a jugular vein. The control unit is configured to drive the electrode device to apply to the site a current in at least first and second bursts, the first burst including a plurality of pulses, and the second burst including at least one pulse, and set (a) a pulse repetition interval (PRI) of the first burst to be on average at least 20 ms, (b) an interburst interval between initiation of the first burst and initiation of the second burst to be less than 10 seconds, (c) an interburst gap between a conclusion of the first burst and the initiation of the second burst to have a duration greater than the average PRI, and (d) a burst duration of the first burst to be less than a percentage of the interburst interval between, the percentage being less than 67%. Other embodiments are also described.

摘要翻译： 提供了包括电极装置和控制单元的装置。 电极装置被配置为耦合到选自以下的对象的部位：迷走神经，心外膜脂肪垫，肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉 ，右心室，右心房和颈静脉。 所述控制单元被配置为驱动所述电极装置以至少第一和第二脉冲串向所述现场应用电流，所述第一脉冲串包括多个脉冲，所述第二脉冲串包括至少一个脉冲，并且设置（a） 脉冲重复间隔（PRI）平均至少为20ms，（b）第一脉冲串的起始与第二脉冲串的起始之间的间歇间隔小于10秒，（c）突发间隙 在第一突发的结论和第二突发的开始之间具有大于平均PRI的持续时间，以及（d）第一突发的突发持续时间小于突发间间隔的百分比，百分比为 小于67％。 还描述了其它实施例。

公开(公告)号：US07908008B2

公开(公告)日：2011-03-15

申请号：US11977646

申请日：2007-10-24

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/18

CPC分类号： A61N1/0556 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A treatment method is provided, including identifying a subject as one who is selected to undergo an interventional medical procedure, and, in response to the identifying, reducing a likelihood of a potential adverse effect of the procedure by applying an electrical current to a parasympathetic site of the subject selected from the group consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a jugular vein of the subject, a right ventricle of the subject, a parasympathetic ganglion of the subject, and a parasympathetic nerve of the subject.

摘要翻译： 提供了一种治疗方法，包括将受试者识别为被选择进行介入医疗程序的受试者，并且响应于鉴定，通过将电流施加到副交感神经部位来减少手术的潜在不利影响的可能性 所述对象选自：受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，受试者的颈动脉，受试者的颈动脉窦，冠状窦 受试者，受试者的静脉静脉，受试者的颈静脉，受试者的右心室，受试者的副交感神经节和受试者的副交感神经。

公开(公告)号：US07885711B2

公开(公告)日：2011-02-08

申请号：US10560654

申请日：2004-06-10

申请人： Omry Ben-Ezra ,  Ehud Cohen ,  Tamir Ben-David

发明人： Omry Ben-Ezra ,  Ehud Cohen ,  Tamir Ben-David

IPC分类号： A61N1/362

CPC分类号： A61N1/0556 ,  A61B5/4035 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： Apparatus (20) for treating a subject (30) suffering from spontaneous atrial fibrillation includes an electrode device (22), adapted to be coupled to a site of the subject (30) selected from the list consisting of: a vagus nerve (24) of the subject (30), an epicardial fat pad of the subject (30), a pulmonary vein of the subject (30), a carotid artery of the subject (30), a carotid sinus of the subject (30), a vena cava vein of the subject (30), and an internal jugular vein of the subject (30), and a control unit (32), adapted to drive the electrode device (22) to apply an electrical current to the site, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.

摘要翻译： 用于治疗患有自发性心房颤动的受试者（30）的装置（20）包括电极装置（22），其适于耦合到选自以下的列表中的受试者（30）的位置：迷走神经（24） 受试者（30）的心外膜脂肪垫，受试者（30）的肺静脉，受试者（30）的颈动脉，受试者（30）的颈动脉窦，体外 受试者（30）的静脉和静脉内部的颈内静脉和控制单元（32），其适于驱动电极装置（22）向该部位施加电流，并且配置 目前为了维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

公开(公告)号：US07634317B2

公开(公告)日：2009-12-15

申请号：US11062324

申请日：2005-02-18

申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/00

CPC分类号： A61B5/412 ,  A61B5/024 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/7217 ,  A61N1/0551 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/3621 ,  A61N1/3627

摘要： Apparatus is provided including an electrode device, adapted to be coupled to a site of a subject; and a control unit, adapted to drive the electrode device to apply a current to the site intermittently during alternating “on” and “off” periods, each of the “on” periods having an “on” duration equal to between 1 and 10 seconds, and each of the “off” periods having an “off” duration equal to at least 50% of the “on” duration. Other embodiments are also described.

摘要翻译： 提供了包括电极装置的装置，其适于联接到受试者的部位; 以及控制单元，其适于在交替的“接通”和“关闭”周期期间驱动电极装置间歇地施加电流到场地，每个“接通”周期具有等于1至10秒的“接通”持续时间 ，并且每个“关闭”周期具有等于“开启”持续时间的至少50％的“关闭”持续时间。 还描述了其它实施例。

公开(公告)号：US20080125819A1

公开(公告)日：2008-05-29

申请号：US11975241

申请日：2007-10-17

申请人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

发明人： Tamir Ben-David ,  Omry Ben-Ezra ,  Ehud Cohen

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36117 ,  A61N1/3621 ,  A61N1/395 ,  A61N1/3962

摘要： A method is provided for treating a subject, including applying a current to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a vena cava vein of the subject, and an internal jugular vein of the subject. The method also includes configuring the current so as to treat a condition of the subject selected from the list consisting of: an autoimmune disease, an autoimmune inflammatory disease, multiple sclerosis, encephalitis, myelitis, immune-mediated neuropathy, myositis, dermatomyositis, polymyositis, inclusion body myositis, inflammatory demyelinating polyradiculoneuropathy, Guillain Barre syndrome, myasthenia gravis, inflammation of the nervous system, inflammatory bowel disease, Crohn's disease, ulcerative colitis, SLE (systemic lupus erythematosus), rheumatoid arthritis, vasculitis, polyarteritis nodosa, Sjogren syndrome, mixed connective tissue disease, glomerulonephritis, thyroid autoimmune disease, sepsis, meningitis, a bacterial infection, a viral infection, a fungal infection, sarcoidosis, hepatitis, and portal vein hypertension.

摘要翻译： 提供了一种用于治疗受试者的方法，包括将电流施加到从包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的动脉，受试者的颈动脉窦，受试者的腔静脉和受试者的颈内静脉。 该方法还包括配置电流以便治疗从以下列表中选择的受试者的状况：自身免疫疾病，自身免疫性炎性疾病，多发性硬化症，脑炎，脊髓炎，免疫介导的神经病，肌炎，皮肌炎，多发性肌炎， 包涵体肌炎，炎性脱髓鞘多发性神经病，吉兰巴利综合征，重症肌无力，神经系统炎症，炎性肠病，克罗恩病，溃疡性结肠炎，SLE（系统性红斑狼疮），类风湿性关节炎，血管炎，结节性多动脉炎，干燥综合征，混合 结缔组织病，肾小球性肾炎，甲状腺自身免疫性疾病，败血症，脑膜炎，细菌感染，病毒感染，真菌感染，结节病，肝炎和门静脉高血压。

公开(公告)号：US20080119898A1

公开(公告)日：2008-05-22

申请号：US11977923

申请日：2007-10-25

申请人： Tamir Ben-David ,  Nitza Gal-on Shoham ,  Ehud Cohen ,  Rami Biran ,  Omry Ben-Ezra

发明人： Tamir Ben-David ,  Nitza Gal-on Shoham ,  Ehud Cohen ,  Rami Biran ,  Omry Ben-Ezra

IPC分类号： A61N1/00

CPC分类号： A61N1/0556 ,  A61N1/205 ,  A61N1/36114

摘要： Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.

摘要翻译： 提供了用于治疗受试者的状况的装置，包括适于与被检体的自主神经联接的电极装置，以及控制单元。 所述控制单元适于驱动所述电极装置向所述神经施加刺激电流，所述刺激电流能够诱导所述神经的第一组和第二组神经纤维中的治疗方向的动作电位，并驱动所述电极 能够抑制在第二组神经纤维中沿治疗方向行进的诱导作用电位的神经抑制电流的装置，第二组神经纤维中的神经纤维的直径通常大于第一组神经纤维中的神经纤维的直径 组。 还描述了其它实施例。

公开(公告)号：US20050149154A1

公开(公告)日：2005-07-07

申请号：US10745514

申请日：2003-12-29

申请人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

发明人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0556

摘要： A dual electrode arrangement, is provided, wherein two, preferably unidirectional, electrode configurations flank a nerve junction from which a preselected nerve branch issues, proximally and distally to the junction, with respect to the brain. The arrangement is conducive to the following: generating efferent action-potential propagations, substantially restricted to the preselected nerve branch, inhibiting afferent action-potential propagations, from the preselected nerve branch, selectively generating action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch, and selectively inhibiting action-potential propagations, in a subset of nerve fibers of a predetermined diameter range, substantially restricted to the preselected nerve branch. The dual electrode arrangement is further conducive to monitoring naturally-occurring, efferent action-potential propagations, heading towards the preselected nerve branch, and monitoring naturally-occurring, afferent action-potential propagations, from the preselected nerve branch. The unidirectional electrode configurations may be monopolar, bipolar, tripolar, or multipolar. Communication with extracorporeal stations, and closed loop operations are also provided.

摘要翻译： 提供了双电极布置，其中两个，优选单向的电极构型位于神经交界处，神经交叉点相对于脑，预选的神经分支向近端向近端和远端发出接合。 该装置有利于：产生传播动作电位传播，基本上限于预选的神经分支，抑制来自预选神经分支的传入动作潜在传播，选择性地产生动作电位传播，在神经纤维的子集中 基本上限于预选神经分支的预定直径范围，以及基本上限于预选神经分支的预定直径范围的神经纤维的子集中选择性抑制动作电位传播。 双电极布置还有助于监测自然发生的，传出的动作电位传播，朝向预选的神经分支，并且从预选的神经分支监测天然存在的，传入的动作电位传播。 单向电极配置可以是单极性，双极性，三极性或多极性。 还提供与体外站的沟通和闭环操作。