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85 条记录 (耗时 0.031 秒)

    Dithiinetetra(thio)carboximides
    51.
    发明授权
    Dithiinetetra(thio)carboximides 失效
    二硫代（硫代）亚胺肟

    公开(公告)号：US08524916B2

    公开(公告)日：2013-09-03

    申请号：US13225412

    申请日：2011-09-03

    申请人： Thomas Himmler ,  Thomas Seitz ,  Ulrike Wachendorff-Neumann

    发明人： Thomas Himmler ,  Thomas Seitz ,  Ulrike Wachendorff-Neumann

    IPC分类号： C07D491/00 ,  A01N43/38

    CPC分类号： C07D495/14 ,  A01N43/90

    摘要： The present invention relates to novel dithiinetetra(thio)carboximides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.

    摘要翻译： 本发明涉及新的二硫代四（硫代）亚胺肟，制备这些化合物的方法，包含这些化合物的组合物，以及其作为生物活性化合物的用途，特别是用于控制作物保护和材料保护中的有害微生物 并作为植物生长调节剂。

    Method for producing 2-(1,2,4-triazol-1-yl)-ethanols
    55.
    发明授权
    Method for producing 2-(1,2,4-triazol-1-yl)-ethanols 有权
    2-（1,2,4-三唑-1-基） - 乙醇的制备方法

    公开(公告)号：US06720428B2

    公开(公告)日：2004-04-13

    申请号：US10203148

    申请日：2002-08-06

    申请人： Thomas Himmler

    发明人： Thomas Himmler

    IPC分类号： C07D24908

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： According to a novel process, microbicidally active 2-(1,2,4-triazol-1-yl)-ethanols of the formula in which A1, A2, R1, R2, R3 and R4 are as defined in the description, can be prepared by reacting hydrazine derivatives of the formula with N-dihalogenomethyl-formamidinium halide of the formula in which X represents chlorine or bromine, if appropriate in the presence of a diluent.

    摘要翻译： 根据一个新方法，式（Ⅱ），A 2，R 1，R 2，R 2， 3>和R 4如说明书中所定义，可以通过使X代表氯或溴的式（Ⅱ）的N-二卤代甲基甲脒卤化物的肼衍生物在稀释剂存在下反应来制备。

    Crystal modification d of 8-cyano-1-cyclopropyl-7-(1s, 6s- 2,8-diazabicyclo-[4.3.0]nonan-8-yl)-6-fluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid
    56.
    发明授权
    Crystal modification d of 8-cyano-1-cyclopropyl-7-(1s, 6s- 2,8-diazabicyclo-[4.3.0]nonan-8-yl)-6-fluoro-1,4- dihydro-4-oxo-3-quinolinecarboxylic acid 失效
    8-氰基-1-环丙基-7-（1s，6s-2,8-二氮杂双环[4.3.0]壬烷-8-基）-6-氟-1,4-二氢-4-氧代 -3-喹啉羧酸

    公开(公告)号：US06492391B1

    公开(公告)日：2002-12-10

    申请号：US09914031

    申请日：2001-08-22

    申请人： Thomas Himmler ,  Hubert Rast

    发明人： Thomas Himmler ,  Hubert Rast

    IPC分类号： A61K3147

    CPC分类号： C07D471/04

    摘要： The present invention relates to a defined crystal modification of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, to processes for its preparation and to its use in pharmaceutical preparations. The crystal modification can be distinguished from other crystal modifications of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of the formula (I) by its characteristic X-ray powder diffractogram and its differential thermodiagram (see description).

    摘要翻译： 本发明涉及8-氰基-1-环丙基-7-（1S，6S-2,8-二氮杂双环[4.3.0]壬烷-8-基）-6-氟-1,4- 二氢-4-氧代-3-喹啉羧酸，其制备方法及其在药物制剂中的应用。晶体修饰可以区别于8-氰基-1-环丙基-7-（1S，6S- 2,8-二氮杂双环[4.3.0]壬烷-8-基）-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸通过其特征X射线粉末衍射图和 其差异热图（见说明）。

    Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
    58.
    发明授权
    Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives 有权
    可取代的8-氰基-1-环丙基-7-（2,8-二氮杂双环[4.3.0] - 壬烷-8-基）-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸 酸及其衍生物

    公开(公告)号：US06323213B1

    公开(公告)日：2001-11-27

    申请号：US09125191

    申请日：1998-08-13

    申请人： Stefan Bartel ,  Thomas Jaetsch ,  Thomas Himmler ,  Hans-Georg Rast ,  Werner Hallenbach ,  Ernst Heinen ,  Franz Pirro ,  Martin Scheer ,  Michael Stegemann ,  Hans-Peter Stupp ,  Heinz-Georg Wetzstein

    发明人： Stefan Bartel ,  Thomas Jaetsch ,  Thomas Himmler ,  Hans-Georg Rast ,  Werner Hallenbach ,  Ernst Heinen ,  Franz Pirro ,  Martin Scheer ,  Michael Stegemann ,  Hans-Peter Stupp ,  Heinz-Georg Wetzstein

    IPC分类号： A61K31407

    CPC分类号： C07D471/04 ,  A01N43/90

    摘要： The present invention relates to novel optionally substituted 8-cyano-1-cyclo-propyl-7-(2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives, of the general formula (I) in which R1 represents hydrogen, C1-C4-alkyl which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, R2 represents hydrogen, benzyl, C1-C3-alkyl, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, radicals having the structures —CH═CH—COOR3, —CH2CH2COOR3, —CH2CH2CN, —CH2CH2COCH3 or —CH2COCH3, in which R3 represents methyl or ethyl, or a radical of the general structure R4—(NH—CHR5—CO)n—, in which R4 represents hydrogen, C1-C3-alkyl or the radical —COO-tert-butyl, R5 represents hydrogen, C1-C4-alkyl, hydroxyalkyl, aminoalkyl, thioalkyl, carboxyalkyl or benzyl and n is 1 or 2, and Y is oxygen or sulfur, the process for their preparation and their use in antibacterial compositions.

    摘要翻译： 本发明涉及新的任选取代的8-氰基-1-环丙基-7-（2,8-二氮杂双环[4.3.0]壬烷-8-基）-6-氟-1,4-二氢-4- 甲氧基，氨基，甲基氨基或二甲基氨基取代的C 1 -C 4 - 烷基，或（5-甲基-2-羟基喹啉羧酸）或其衍生物，其中R 1表示氢， 氧代-1,3-二氧杂环戊烯-4-基）甲基，R 2表示氢，苄基，C 1 -C 3 - 烷基，（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基， 结构-CH = CH-COOR 3，-CH 2 CH 2 COOR 3，-CH 2 CH 2 CN，-CH 2 CH 2 COCH 3或-CH 2 COCH 3，其中R 3表示甲基或乙基，或通式结构R4-（NH-CHR5-CO）n - 的基团，其中R4 代表氢，C 1 -C 3 - 烷基或-COO-叔丁基，R 5表示氢，C 1 -C 4 - 烷基，羟基烷基，氨基烷基，硫代烷基，羧基烷基或苄基，n是1或2，Y是氧或硫， 其制备方法及其在抗菌组合物中的应用。