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1.发明授权4-Heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein 失效4-杂芳基四氢喹啉及其作为胆固醇酯转移蛋白的抑制剂的用途公开(公告)号：US07192971B2
公开(公告)日：2007-03-20
申请号：US11257931
申请日：2005-10-25
申请人： Jürgen Stoltefuss , Michael Lörges , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
发明人： Jürgen Stoltefuss , Michael Lörges , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
IPC分类号： A61K31/4709 , C07D401/04
CPC分类号： C07D401/04 , C07D215/20 , C07D409/04
摘要： Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
摘要翻译： 异四氢喹啉可以通过将相应取代的杂四氢喹啉醛与所需的取代基缩合或通过还原相应的酮取代的杂四氢喹啉来制备，然后通过常规方法引入所需的取代基。 杂四氢喹啉适合用作药物中的活性化合物，特别是用于治疗动物硬化和血脂异常的药物。
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公开(公告)号：US5932587A
公开(公告)日：1999-08-03
申请号：US883673
申请日：1997-06-27
申请人： Carsten Schmeck , Matthias Muller-Gliemann , Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Logers , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher
发明人： Carsten Schmeck , Matthias Muller-Gliemann , Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Logers , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher
IPC分类号： C07D491/044 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/445 , A61K31/451 , A61K31/55 , A61P3/06 , A61P9/10 , C07C229/14 , C07D211/86 , C07D211/90 , C07D213/80 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/20 , C07D493/14 , C07D495/04 , C07F7/18
CPC分类号： C07D213/80 , C07C229/14 , C07D211/86 , C07D211/90 , C07D471/04 , C07D491/04 , C07D495/04 , C07F7/1856
摘要： The heterocyclic-fused pyridines are prepared by reaction of the corresponding heterocyclic-fused pyridine aldehydes with appropriately substituted Grignard or Wittig reagents. The heterocyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of dislipidaemia and arteriosclerosis.
摘要翻译： 杂环稠合的吡啶通过相应的杂环稠合吡啶醛与适当取代的格利雅或维蒂希试剂的反应来制备。 杂环稠合的吡啶适合作为药物中的活性化合物，特别是用于治疗血脂异常和动脉硬化的药物。
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公开(公告)号：US5811433A
公开(公告)日：1998-09-22
申请号：US878683
申请日：1997-06-19
IPC分类号： A61K31/435 , C07D471/02 , C07D471/04 , C07D498/16 , C07D519/00
CPC分类号： C07D471/04
摘要： The invention relates to novel 1,6-naphthyridonecarboxylic acid derivatives, to processes for their preparation, to antibacterial compositions and feed additives in which they are present, and to novel intermediates for the preparation of these active compounds.
摘要翻译： 本发明涉及新颖的1,6-萘啶酮羧酸衍生物，其制备方法，其中存在的抗菌组合物和饲料添加剂，以及用于制备这些活性化合物的新型中间体。
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公开(公告)号：US5480879A
公开(公告)日：1996-01-02
申请号：US131253
申请日：1993-10-01
申请人： Uwe Petersen , Wilfried Schrock , Dieter Habich , Andreas Krebs , Thomas Schenke , Thomas Philipps , Klaus Grohe , Rainer Endermann , Klaus-Dieter Bremm , Karl-Georg Metzger
发明人： Uwe Petersen , Wilfried Schrock , Dieter Habich , Andreas Krebs , Thomas Schenke , Thomas Philipps , Klaus Grohe , Rainer Endermann , Klaus-Dieter Bremm , Karl-Georg Metzger
IPC分类号： A61K31/43 , A61K31/435 , A61K31/47 , A61K31/535 , A61K31/545 , A61P31/04 , C07D417/12 , C07D463/00 , C07D477/00 , C07D477/14 , C07D498/04 , C07D499/88 , C07D501/00 , C07D501/16 , C07D513/06 , C07D519/00 , C07D519/06 , C07D487/04
CPC分类号： C07D477/14 , C07D499/88 , C07D501/00
摘要： The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are linked to a .beta.-lactam antibiotic, to their salts, to processes for their preparation and to antibacterial agents containing these derivatives.
摘要翻译： 本发明涉及与β-内酰胺抗生素连接的喹诺酮羧酸和萘啶酮羧酸的新型衍生物，其盐，其制备方法和含有这些衍生物的抗菌剂。
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公开(公告)号：US5468742A
公开(公告)日：1995-11-21
申请号：US146569
申请日：1993-11-01
申请人： Uwe Petersen , Thomas Himmler , Thomas Schenke , Andreas Krebs , Klaus Grohe , Klaus-Dieter Bremm , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
发明人： Uwe Petersen , Thomas Himmler , Thomas Schenke , Andreas Krebs , Klaus Grohe , Klaus-Dieter Bremm , Karl G. Metzger , Rainer Endermann , Hans-Joachim Zeiler
IPC分类号： C07D215/56 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/04 , A61K31/47 , A61K31/535 , C07D498/02
CPC分类号： C07D215/56 , C07D401/04 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.
摘要翻译： 本发明涉及新的8-乙烯基和8-乙炔基喹诺酮羧酸，其制备方法，以及含有它们的抗菌剂和饲料添加剂。
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6.发明授权4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein 失效4-杂芳基 - 四氢喹啉及其作为胆固醇 - 酯转移蛋白的抑制剂的用途公开(公告)号：US06958346B2
公开(公告)日：2005-10-25
申请号：US09999233
申请日：2001-10-31
申请人： Jürgen Stoltefuss , Michael Lögers , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
发明人： Jürgen Stoltefuss , Michael Lögers , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
IPC分类号： A61K31/47 , A61K31/4709 , A61P3/06 , A61P9/10 , A61P31/06 , C07D215/20 , C07D401/04 , C07D405/04 , C07D409/04 , C07F7/18 , C07D401/08
CPC分类号： C07D401/04 , C07D215/20 , C07D409/04
摘要： Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
摘要翻译： 异四氢喹啉可以通过将相应取代的杂四氢喹啉醛与所需的取代基缩合或通过还原相应的酮取代的杂四氢喹啉来制备，然后通过常规方法引入所需的取代基。 杂四氢喹啉适合用作药物中的活性化合物，特别是用于治疗动物硬化和血脂异常的药物。
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公开(公告)号：US06586613B1
公开(公告)日：2003-07-01
申请号：US09508958
申请日：2000-03-17
申请人： Arndt Brandes , Michael Lögers , Jürgen Stoltefuss , Gunter Schmidt , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Stefan Antons , Holger Paulsen , Stephan Nicholas Müller , Paul Naab , Carsten Schmeck
发明人： Arndt Brandes , Michael Lögers , Jürgen Stoltefuss , Gunter Schmidt , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Stefan Antons , Holger Paulsen , Stephan Nicholas Müller , Paul Naab , Carsten Schmeck
IPC分类号： C07F708
CPC分类号： C07C69/76 , C07C35/52 , C07C43/192 , C07C49/83 , C07C69/757 , C07C69/94 , C07F7/1804
摘要： Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds by customary methods and converting functional groups in this manner into the desired groups. The compounds according to the invention are suitable for use as active compounds in pharmaceuticals, in particular in pharmaceuticals for treating arteriosclerosis and also dyslipidaemias.
摘要翻译： 通过常规方法通过还原或缩合取代的四氢萘和类似化合物中的适当官能取代基并以这种方式将官能团转化为所需基团来制备取代的四氢萘和类似化合物。 根据本发明的化合物适合用作药物中的活性化合物，特别是用于治疗动脉硬化的药物以及血脂异常。
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8.发明授权4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein 失效4-杂芳基 - 四氢喹啉及其作为胆固醇 - 酯转移蛋白的抑制剂的用途公开(公告)号：US06387929B1
公开(公告)日：2002-05-14
申请号：US09508399
申请日：2000-03-10
申请人： Jürgen Stoltefuss , Michael Lögers , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
发明人： Jürgen Stoltefuss , Michael Lögers , Gunter Schmidt , Arndt Brandes , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt
IPC分类号： A61K314706
CPC分类号： C07D401/04 , C07D215/20 , C07D409/04
摘要： Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
摘要翻译： 异四氢喹啉可以通过将相应取代的杂四氢喹啉醛与所需的取代基缩合或通过还原相应的酮取代的杂四氢喹啉来制备，然后通过常规方法引入所需的取代基。 杂四氢喹啉适合用作药物中的活性化合物，特别是用于治疗动物硬化和血脂异常的药物。
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公开(公告)号：US6069160A
公开(公告)日：2000-05-30
申请号：US631516
申请日：1996-04-12
申请人： Andreas Stolle , Dieter Habich , Stephan Bartel , Bernd Riedl , Martin Ruppelt , Hanno Wild , Rainer Endermann , Klaus-Dieter Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
发明人： Andreas Stolle , Dieter Habich , Stephan Bartel , Bernd Riedl , Martin Ruppelt , Hanno Wild , Rainer Endermann , Klaus-Dieter Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
IPC分类号： A61K31/40 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/655 , A61K31/66 , A61P31/04 , C07D263/58 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/04 , C07F9/6558 , C07F9/6584 , A61K31/428 , C07D263/54 , C07D277/62
CPC分类号： C07D263/58 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/04 , C07F9/6558 , C07F9/65842
摘要： The invention relates to heteroatom-containing benzocyclopentaneoxazolidinones, to processes for their preparation and their use as medicaments, especially as antibacterial medicaments.
摘要翻译： 本发明涉及含杂原子的苯并环戊恶唑烷酮，其制备方法及其作为药物的用途，特别是作为抗菌药物。
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公开(公告)号：US6069148A
公开(公告)日：2000-05-30
申请号：US889530
申请日：1997-07-08
申请人： Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Logers , Matthias Muller-Gliemann , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher , Henry Giera , Holger Paulsen , Paul Naab , Michael Conrad , Jurgen Stoltefuss
发明人： Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Logers , Matthias Muller-Gliemann , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher , Henry Giera , Holger Paulsen , Paul Naab , Michael Conrad , Jurgen Stoltefuss
IPC分类号： C07D215/20 , A61K31/435 , A61K31/47 , A61K31/4709 , A61K31/473 , A61P3/06 , A61P9/00 , A61P9/10 , C07C225/18 , C07D215/22 , C07D215/36 , C07D215/40 , C07D215/54 , C07D221/04 , C07D221/16 , C07D221/20 , C07D405/06 , C07D491/056 , C07D491/08 , C07D491/10 , C07D491/107 , C07F7/18 , A61K31/438 , C07D215/00 , C07D217/00
CPC分类号： C07D221/04 , C07C225/18 , C07D215/22 , C07D215/36 , C07D215/40 , C07D221/16 , C07D221/20 , C07D405/06 , C07D491/08 , C07D491/10 , C07F7/1856 , C07C2101/08
摘要： The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.
摘要翻译： 通过使相应的环烷基 - 吡啶 - 醛与合适的有机金属化合物或Wittig或格氏试剂反应或使环烷基 - 吡啶醇类型的化合物与合适的溴化合物反应，并且任选地相应地改变官能团，制备环烷基 - 吡啶。 环烷基吡啶类药物适合作为药物中的活性化合物，特别是用于治疗高脂蛋白血症和动脉硬化的药物。
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