公开(公告)号：US5837255A

公开(公告)日：1998-11-17

申请号：US762785

申请日：1996-12-10

申请人： Wayne DeWald Inman ,  Jian Luo

发明人： Wayne DeWald Inman ,  Jian Luo

IPC分类号： A61K31/155 ,  A61K31/40 ,  A61K31/425 ,  A61K31/495 ,  A61K31/55 ,  A61K31/64 ,  A61K31/70 ,  A61K36/38 ,  A61K38/28 ,  A61K35/78 ,  A61K31/12 ,  C07C50/18

CPC分类号： A61K31/64 ,  A61K31/155 ,  A61K31/40 ,  A61K31/425 ,  A61K31/495 ,  A61K31/55 ,  A61K31/70 ,  A61K36/38 ,  A61K38/28 ,  Y10S514/884

摘要： The use of extracts from Harungana or Vismia spp. or anthracenone compounds harunganin and vismin contained therein or isolated therefrom as hypoglycemic agents, as well as methods for obtaining the hypoglycemic agents are described. According to a preferred embodiment, the extracts are derived from H. madagascariensis. As hypoglycemic agents, the extracts or anthracenone compounds harunganin and vismin are useful for treating insulin-dependent (type I) and non-insulin-dependent (type II) diabetes.

摘要翻译： 使用来自Harungana或Vismia spp。的提取物 或蒽醌类化合物harunganin和其中含有的粘膜或其作为降血糖剂分离，以及获得降血糖剂的方法。 根据一个优选的实施方案，提取物来源于马达加斯加哈马斯。 作为降血糖药，提取物或蒽醌类化合物harunganin和粘膜可用于治疗胰岛素依赖型（I型）和非胰岛素依赖型（II型）糖尿病。

公开(公告)号：US5827898A

公开(公告)日：1998-10-27

申请号：US726591

申请日：1996-10-07

申请人： Atul S. Khandwala ,  Jian Luo

发明人： Atul S. Khandwala ,  Jian Luo

IPC分类号： A61K45/00 ,  A61K31/05 ,  A61K31/216 ,  A61P3/10 ,  A61P43/00

CPC分类号： A61K31/05 ,  Y10S514/866

摘要： This invention is directed to methods for treatment of non-insulin-dependent diabetes mellitus, for reducing blood glucose levels, or hyperglycemia. The methods entail administering to a mammal in need of such treatment a therapeutically effective amount of a composition whose active ingredient consists essentially of a compound of the following structure or a pharmaceutically acceptable salt thereof: ##STR1## In the compound R and R' are independently H or a C.sub.1 -C.sub.20 alkyl or C.sub.2 -C.sub.20 alkenyl group which may be substituted or unsubstituted. Alternatively, R and R' are such that together a cycloalkyl or cycloalkenyl ring is formed. In the chain linking the two phenolic derivatives each of (C(R).dbd.C(R')) or (C(R)(R')) are the same or different. A and A' are independently C.sub.2 -C.sub.20 acylamino, C.sub.2 -C.sub.20 acyloxy, C.sub.2 -C.sub.20 alkanoyl, C.sub.2 -C.sub.20 alkoxycarbonyl, C.sub.1 -C.sub.20 alkoxyl, C.sub.1 -C.sub.20 alkyl amino, C.sub.2 -C.sub.20 alkyl carboxyl, amino, C.sub.2 -C.sub.20 carbalkoxyl, carboxyl, cyano, halo, hydroxy. B and B' are independently H, C.sub.2 -C.sub.20 alkanoyl, C.sub.3 -C.sub.20 alkenoyl, C.sub.2 -C.sub.20 alkenyl, C.sub.2 -C.sub.20 alkoxycarbonyl, C.sub.1 -C.sub.20 alkyl, aroyl, aralkanoyl, C.sub.2 -C.sub.20 carbamoyl, or phosphate. The invention is also directed to methods of treatment using a bisphenolic compound in conjunction with another hypoglycemic or hypolipidemic agent.

摘要翻译： 本发明涉及用于治疗非胰岛素依赖性糖尿病，用于降低血糖水平或高血糖症的方法。 所述方法需要对需要这种治疗的哺乳动物施用治疗有效量的组合物，其活性成分基本上由以下结构的化合物或其药学上可接受的盐组成：化合物R和R'独立地为 H或可以是取代或未取代的C 1 -C 20烷基或C 2 -C 20烯基。 或者，R和R'使得形成环烷基或环烯基环。 在连接（C（R）= C（R'））或（C（R）（R'））的两个酚衍生物的链可以相同或不同。 A和A'独立地为C 2 -C 20酰基氨基，C 2 -C 20酰氧基，C 2 -C 20烷酰基，C 2 -C 20烷氧基羰基，C 1 -C 20烷氧基，C 1 -C 20烷基氨基，C 2 -C 20烷基羧基，氨基，C 2 -C 20碳烷氧基， 羧基，氰基，卤素，羟基。 B和B'独立地为H，C 2 -C 20烷酰基，C 3 -C 20链烯酰基，C 2 -C 20烯基，C 2 -C 20烷氧基羰基，C 1 -C 20烷基，芳酰基，芳烷酰基，C 2 -C 20氨基甲酰基或磷酸酯。 本发明还涉及使用双酚化合物与另一种降血糖或降血脂药联合治疗的方法。

公开(公告)号：US5789962A

公开(公告)日：1998-08-04

申请号：US638330

申请日：1996-04-26

申请人： Guoliang Shou ,  Kazunori Motohashi ,  Jian Luo ,  Sunao Takatori ,  Makoto Yamamoto

发明人： Guoliang Shou ,  Kazunori Motohashi ,  Jian Luo ,  Sunao Takatori ,  Makoto Yamamoto

IPC分类号： G06J1/00 ,  G06F7/44

CPC分类号： G06J1/00

摘要： A multiplication circuit has two capacitive couplings connected first and second inverting amplifiers, respectively. Two steps of multiplication are performed by this circuit. Input is multiplied by a multiplier of a product of multipliers of the successive multiplication circuits, so the total multiplier can be rather large with similar capacitances to that of the conventional circuit.

摘要翻译： 乘法电路分别具有连接第一和第二反相放大器的两个电容耦合。 该电路执行两步乘法运算。 输入乘以连续乘法电路的乘法乘积乘法器，因此与常规电路的乘法电容相似，总乘法器可能相当大。