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    Method of detecting collisions in graphics processing unit
    52.
    发明授权
    Method of detecting collisions in graphics processing unit 有权
    检测图形处理单元中碰撞的方法

    公开(公告)号：US08717382B2

    公开(公告)日：2014-05-06

    申请号：US13175173

    申请日：2011-07-01

    Applicant: Young Jun Kim ,  Fuchang Liu

    Inventor： Young Jun Kim ,  Fuchang Liu

    IPC: G09G5/00

    CPC classification number: G06T17/00 ,  A63F2300/643 ,  G06T2210/21

    Abstract: The present invention relates to a method of detecting collisions on a Graphics Processing Unit (GPU). Each collision detection object Oi is projected onto a reference direction, thus obtaining an interval Ii represented by a set {mi, Mi}. Radix sorting based on obtained mi for all Oi, thus obtaining a sorted list L. The sorted list is swept, and then colliding pairs Pi are detected. All colliding pairs are configured into a single set, thus obtaining a final colliding pair P. On a GPU, SaP can be performed on a plurality of collision detection objects in parallel using the blocks of a plurality of threads.

    Abstract translation: 本发明涉及一种检测图形处理单元（GPU）上的碰撞的方法。 将每个碰撞检测对象Oi投影到参考方向，从而获得由集合{mi，Mi}表示的间隔Ii。 基于所有Oi的获得的mi的基数排序，从而获得排序列表L.扫描排序列表，然后检测到对对Pi。 所有的碰撞对被配置成一组，从而获得最终的碰撞对P.在GPU上，可以使用多个线程的块并行地对多个冲突检测对象执行SaP。

    METHOD FOR INHIBITING ANGIOGENESIS
    57.
    发明申请
    METHOD FOR INHIBITING ANGIOGENESIS 有权
    抑制血管生成的方法

    公开(公告)号：US20120328617A1

    公开(公告)日：2012-12-27

    申请号：US13536213

    申请日：2012-06-28

    Applicant: Sang Won Kang ,  Dong Hoon Kang ,  Doo Jae Lee

    Inventor： Sang Won Kang ,  Dong Hoon Kang ,  Doo Jae Lee

    IPC: A61K31/713 ,  A61K31/7088 ,  A61P35/00 ,  A61P27/02 ,  G01N21/77 ,  A61P17/06 ,  A61P29/00 ,  A61P1/16 ,  A61P13/12 ,  A61P25/00 ,  A61K39/395 ,  A61P37/08

    CPC classification number: A61K31/713 ,  G01N33/5023

    Abstract: The present invention relates to a method for inhibiting angiogenesis using a peroxiredoxin II (Prx II) inhibitor, and a method for preparing angiogenesis-inhibiting medicines using Prx II inhibitor. According to the present invention, the inhibitor of Prx II gene expression or Prx II protein activity increases oxidative inactivation of VEGF receptor tyrosine kinase (RTK) to reduce VEGF signaling, thereby screening a novel angiogenesis inhibitor. Therefore, the method of the present invention can be used for the prevention or treatment of various diseases, ailments, and conditions related to angiogenesis.

    Abstract translation: 本发明涉及使用过氧氧化还原酶II（Prx II）抑制剂抑制血管发生的方法，以及使用Prx II抑制剂制备血管生成抑制药物的方法。 根据本发明，Prx II基因表达抑制剂或Prx II蛋白活性增加VEGF受体酪氨酸激酶（RTK）的氧化失活以减少VEGF信号传导，从而筛选新型血管生成抑制剂。 因此，本发明的方法可以用于预防或治疗与血管发生有关的各种疾病，疾病和病症。

    PHARMACEUTICAL COMPOSITION FOR INHIBITING ABNORMAL PROLIFERATION OF CELLS
    58.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR INHIBITING ABNORMAL PROLIFERATION OF CELLS 有权
    用于抑制细胞异常增殖的药物组合物

    公开(公告)号：US20120308568A1

    公开(公告)日：2012-12-06

    申请号：US13577231

    申请日：2011-02-07

    Applicant: Sang Won Kang ,  Soo Young Lee

    Inventor： Sang Won Kang ,  Soo Young Lee

    IPC: A61K39/395 ,  A61K31/7088 ,  A61P35/00 ,  A61P29/00 ,  A61P19/02 ,  A61P3/10 ,  A61P11/06 ,  A61P17/00 ,  A61P1/00 ,  A61P19/00 ,  A61K31/713 ,  A61P9/00

    CPC classification number: C12N15/1135 ,  A61K39/00 ,  C12N2310/11

    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diseases related to abnormal proliferation of cells, comprising a cytoplasmic heat shock protein (Hsp)60 kDa inhibitor as an active ingredient, and to a screening method and a kit using the composition. According to the present invention, substances which inhibit expression of cytoplasmic Hsp 60 genes or inhibit activity of cytoplasmic Hsp 60 or inhibit binding between cytoplasmic Hsp 60 and IKK protein prevent interaction between cytoplasmic Hsp 60 and IKK complexes to make NF-κB path inactive, and thus induce apoptosis. Therefore, the substances can be valuably used in preventing or treating diseases related to abnormal proliferation of cells, such as cancer, inflammatory diseases or hyperproliferative vascular diseases.

    Abstract translation: 本发明涉及用于预防或治疗与细胞异常增殖有关的疾病的药物组合物，其包含细胞质热休克蛋白（Hsp）60kDa抑制剂作为活性成分，以及使用该组合物的筛选方法和试剂盒。 根据本发明，抑制细胞质Hsp 60基因表达或抑制细胞质Hsp60活性或抑制细胞质Hsp60与IKK蛋白结合的物质可防止细胞质Hsp60与IKK复合体之间的相互作用，使NF-和κB途径失活 ，从而诱导细胞凋亡。 因此，这些物质可以有效地用于预防或治疗与癌症，炎性疾病或过度增生性血管疾病等细胞异常增殖有关的疾病。

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