公开(公告)号：US11523076B2

公开(公告)日：2022-12-06

申请号：US17340049

申请日：2021-06-06

申请人： The Regents of the University of Colorado, a body corporate

发明人： Justin Waugh ,  Daniel S. Dessau ,  Stephen P. Parham ,  Thomas Nummy ,  Justin Griffith ,  Xiaoqing Zhou ,  Haoxiang Li

IPC分类号： H04N5/361 ,  H04N5/235 ,  H04N5/351 ,  H04N5/3745

摘要： A quantitative pulse count (event detection) algorithm with linearity to high count rates is accomplished by combining a high-speed, high frame rate camera with simple logic code run on a massively parallel processor such as a GPU or a FPGA. The parallel processor elements examine frames from the camera pixel by pixel to find and tag events or count pulses. The tagged events are combined to form a combined quantitative event image.

公开(公告)号：US20220373397A1

公开(公告)日：2022-11-24

申请号：US17742277

申请日：2022-05-11

申请人： The Regents of the University of Colorado, a body corporate

发明人： Juliet T. Gopinath ,  Greg Krueper ,  Lior Cohen

IPC分类号： G01J9/02 ,  G02F1/365 ,  G02F1/35 ,  G02F1/39 ,  G02F1/355

摘要： An entanglement-enhanced interferometry system includes a source of correlated photons configured to two-mode squeezed vacuum (TMSV), a polarizing splitter or off-axis polarizing coupler configured to separate the correlated photons into two paths, a polarization control device configured to rotate polarization of photons on one of the two paths relative to the photons on the other of the two paths in order to make photons indistinguishable, a coupler configured to entangle the indistinguishable photons, and a polarization maintaining fiber-based interferometer configured to use the entangled photons as the input state. The source of correlated photons might be a nonlinear element such as a periodically poled element such as a lithium niobate bulk crystal or waveguide. The interferometer might be a Mach-Zehnder or a common path configuration. The coupler might be a 50:50 coupler or a polarizing coupler 45 degrees off-axis.

公开(公告)号：US20220349628A1

公开(公告)日：2022-11-03

申请号：US17857778

申请日：2022-07-05

申请人： The Regents of the University of Colorado, a body corporate

发明人： Vincent Kotsubo ,  Joel Ullom ,  Sae Woo Nam

IPC分类号： F25B9/02 ,  F25B9/14 ,  F25B9/10

摘要： A compact, low power cryo-cooler for cryogenic systems capable of cooling gas to at least as low as 2.5 K. The cryo-cooler has a room temperature compressor followed by filtration. Within the cryostat, four counterflow heat exchangers precool the incoming high-pressure gas using the outflowing low-pressure gas. The three warmest heat exchangers are successively heat sunk to three stages of a pulse tube to absorb residual heat from the slight ineffectiveness of the heat exchangers. The pulse tube cold head also absorbs loads from instrumentation leads and radiation loads. The pulse tube stages operate at around 80 K, 25 K, and 10 K. The entire system—cryo-cooler, drive and control electronics, and detector instrumentation, fits in a standard electronics rack mount enclosure, and requires around 300 W or less of power.

公开(公告)号：US20220315706A1

公开(公告)日：2022-10-06

申请号：US17616922

申请日：2020-06-08

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： CHRISTOPHER N. BOWMAN ,  MARVIN DION ALIM ,  MATTHEW K. MCBRIDE ,  KIMBERLY KAY-CHILDRESS ,  JUAN J. HERNANDEZ ,  JEFFREY W. STANSBURY

IPC分类号： C08G75/045 ,  B33Y70/00 ,  C08F2/50 ,  C08F218/16

摘要： In one aspect, the disclosure relates to compositions comprising semicrystalline, linear photopolymers that possesses extraordinary mechanical properties for application in 3D printing. The photopolymers are rapidly fabricated using low viscosity liquids at ambient conditions.

公开(公告)号：US11463026B2

公开(公告)日：2022-10-04

申请号：US16855892

申请日：2020-04-22

申请人： The Regents of the University of Colorado, a body corporate

发明人： Garret Moddel

IPC分类号： H02N11/00 ,  H01L49/00 ,  H01L39/14

摘要： Described herein are devices incorporating plasmon Casimir cavities, which modify the distribution of allowable plasmon modes within the cavities. The plasmon Casimir cavities can drive charge carriers from or to an electronic device adjoining the plasmon Casimir cavity by modifying the distribution of zero-point energy-driven plasmons on one side of the electronic device to be different from the distribution of zero-point energy-driven plasmons on the other side of the electronic device. The electronic device can exhibit a structure that permits transport or capture of carriers in very short time intervals, such as in 1 picosecond or less.

公开(公告)号：US20220311360A1

公开(公告)日：2022-09-29

申请号：US17589239

申请日：2022-01-31

申请人： The Regents of the University of Colorado, a body corporate

发明人： Garret Moddel

IPC分类号： H02N11/00 ,  H01L33/00 ,  C25B1/04 ,  B01J19/12 ,  H01L33/04 ,  C25B9/17

摘要： Described herein are systems incorporating a Casimir cavity, such as an optical Casimir cavity or a plasmon Casimir cavity. The Casimir cavity modifies the zero-point energy density therein as compared to outside of the Casimir cavity. The Casimir cavities are paired in the disclosed systems with product generating devices and the difference in zero-point energy densities is used to directly drive the generation of products, such as chemical reaction products or emitted light.

公开(公告)号：US11454682B2

公开(公告)日：2022-09-27

申请号：US16572409

申请日：2019-09-16

申请人： The Regents of the University of Colorado, a body corporate

发明人： Vladislav Gerginov ,  Fabio da Silva

IPC分类号： G01R33/26

摘要： Various embodiments of the present technology use low-frequency magnetic signals for communication and location applications. Compared to the case of traditionally used radio-frequency electromagnetic signals, their advantage in the presence of strong signal attenuation is in the extended spatial range. Some embodiments use an optically pumped atomic magnetometer operated as a sensor to achieve high detection sensitivity. The spatial range can be extended to hundreds of meters when noise is suppressed by the use of the available sensor sensitivity. In some embodiments, a one-channel spread-spectrum signal processing technique can be used to eliminate the systematic fluctuations coming from power grid (or another source) harmonics and reduce the ambient noise by averaging uncorrelated fluctuations from the environment.

公开(公告)号：US20220291235A1

公开(公告)日：2022-09-15

申请号：US17635632

申请日：2020-08-28

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO - A BODY CORPORATE

发明人： Xiaoyun Ding

IPC分类号： G01N33/68 ,  B01L3/00

摘要： Thermal shift assays (TSAs) have been extensively used to study thermodynamics of proteins and provide an efficient means to assess protein-ligand binding or protein-protein interaction. However, existing TSAs have limitations such as time consuming, labor intensive, or low sensitivity. Here, an acousto-thermal shift assay (A-TSA) is disclosed and is believed to be the first ultrasound enabled TSA which can provide a real-time analysis of protein thermodynamic stability. A-TSA couples unique acoustic mechanisms to achieve protein unfolding, concentration, and measurement on a single microfluidic chip within minutes. Compared to conventional TSA methods, A-TSA provides an ultra-fast (at least 30 times faster), highly sensitive (7-34 folds higher), and label -free monitoring of protein-ligand interactions and protein stability finding applications for protein analysis in biology, medicine and fast diagnosis.

公开(公告)号：US11441193B2

公开(公告)日：2022-09-13

申请号：US16857767

申请日：2020-04-24

申请人： The Regents of the University of Colorado, a body corporate

发明人： Shi-long Lu ,  John Song

IPC分类号： C12Q1/6886 ,  C12Q1/70

摘要： Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (HNSCC). These results represent the first use of quantitative MS-PCR for the detection of mgmiRs. In addition, this panel demonstrates the ability to detect hypermethylation in the adjacent mucosa of cancer patients, suggesting its utility in early detection. This panel is also capable of detecting cancer by using saliva, blood and FNA tissue samples.

公开(公告)号：US20220280126A1

公开(公告)日：2022-09-08

申请号：US17572718

申请日：2022-01-11

申请人： The Regents of the University of Colorado, a body corporate

发明人： Cem Altunbas

IPC分类号： A61B6/00 ,  G01T1/20 ,  G01T7/00

摘要： The present invention relates generally to X-ray detectors and more particularly to a system and a method for integrating an anti-scattering grid with scintillators to significantly enhance the performance of flat panel X-ray detector. In particular, the performance of a flat panel X-ray detector may be enhanced by photon counting detector pixels configured underneath the septa of a 2D antiscatter grid.