-
公开(公告)号:US20220216057A1
公开(公告)日:2022-07-07
申请号:US17608956
申请日:2020-05-08
Applicant: Consiglio Nazionale Delle Ricerche
Inventor: Rosaria Anna PUGLISI , Sebastiano CACCAMO
IPC: H01L21/225 , H01L21/02
Abstract: Method of doping a semiconductor sample in a uniform and carbon-free way, wherein said sample has a surface, comprising the following steps: A. removing oxides from at least part of the said surface; B. dip coating said at least part of the surface of the sample in a dopant based carbon-free solution of at least one dopant based carbon free substance diluted in water, wherein said at least one dopant based carbon free substance has a molecule comprising at least one dopant atom, wherein the dip coating is achieved by heating said dopant based carbon-free solution at a dip coating temperature from 65% to 100% of the boiling temperature of said dopant based carbon-free solution, thereby a self-assembled mono-layer including dopant atoms is formed; C. annealing said sample, wherein the annealing is configured to cause said dopant atoms included in said self-assembled mono-layer to be diffused into the sample.
-
公开(公告)号:US20220183961A1
公开(公告)日:2022-06-16
申请号:US17599168
申请日:2020-03-27
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Michele IAFISCO , Alessio ADAMIANO , Clara PICCIRILLO
Abstract: It is described a process, starting from fishbones, for the production of a material having properties of physical type solar filter and photoprotective boosting agent, formed by particles of hydroxyapatite or hydroxyapatite substituted with metal ions, optionally mixed with calcium triphosphate and with metal oxides. Are also described the material obtained through the process and cosmetic or plant sunscreen compositions that comprise said material.
-
公开(公告)号:US11346719B2
公开(公告)日:2022-05-31
申请号:US17269432
申请日:2019-07-25
Applicant: POLITECNICO DI MILANO , CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Cristian Angelo Manzoni , Giulio Cerullo , Dario Polli , Antonio Perri , Fabrizio Preda , Gianluca Valentini , Andrea Bassi
Abstract: A Fourier-transform hyperspectral imaging system may include an optical imaging system configured to produce an image of an object, and an adjustable birefringent common-path interferometer module comprising a movable birefringent element and configured to produce interfering replicas of an input radiation which are delayed from each other by a phase delay adjustable by the moving birefringent element. The interferometer module may be configured to produce collinear replicas for entering optical rays parallel to said optical axis. The hyperspectral imaging system further comprises a two-dimensional light detector configured to receive the replicas and provide digital images of the object depending on said adjustable phase delay. The system also includes an analysis device configured to perform a Fourier Transform of the digital images to obtain a hyperspectral representation of the object.
-
公开(公告)号:US20220153119A1
公开(公告)日:2022-05-19
申请号:US16489415
申请日:2018-02-27
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Luigi DE SIMIO , Michele GAMBINO , Sabato IANNACCONE
Abstract: The propulsion system comprises a heat engine, a transmission unit for transmitting to the vehicle wheels power supplied by the heat engine, an auxiliary power unit for storing and supplying energy, a planetary gear set interposed between the heat engine and the transmission unit and connected to the auxiliary power unit, a locking device associated with the planetary gear set and shiftable between a first position, wherein the auxiliary power unit does not exchange power with the planetary gear set, and a second position, wherein the auxiliary power unit exchanges power with the planetary gear set, and a braking device which is interposed between the planetary gear set and the heat engine and is configured to modulate the motion resistance torque of the heat engine.
-
公开(公告)号:US11237375B2
公开(公告)日:2022-02-01
申请号:US16473952
申请日:2017-12-21
Applicant: LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI (LENS) , CONSIGLIO NAZIONALE DELLE RICERCHE—CNR , UNIVERSITA′ DEGLI STUDI DI FIRENZE
Inventor: Ludovico Silvestri , Marie Caroline Mullenbroich , Leonardo Sacconi , Francesco Saverio Pavone
Abstract: A system and a method for measuring the focus state of an optical instrument are described. The system and the method provide for forming an image of the exit pupil of the objective of the optical instrument. Where the image of the exit pupil is formed, one or more optical elements are placed, deviating at least part of the rays coming from the exit pupil, so that rays coming from different non-overlapping portions of the pupil follow separate optical paths. The rays coming from the two portions of the pupil are then focused, in order to obtain two bidimensional images. A computer determines the mutual distance between these two bidimensional images as a mutual rigid lateral displacement between the two and, based on this distance, determines the corresponding defocus of the optical instrument.
-
66.
公开(公告)号:US11189433B2
公开(公告)日:2021-11-30
申请号:US16620788
申请日:2018-06-08
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Alessandro Cannavale , Pierluigi Cossari , Vincenzo Maiorano , Giuseppe Gigli
Abstract: A multifunctional solid-state photovoltachromic device (1) comprising at least one n-type layer (8) and at least one p-type layer (11) arranged to create a PN or PIN junction, said n-type layer (8) and p-type layer (11) comprising materials arranged to act as mixed conductors, thus allowing both charge transport and ion conduction.
-
公开(公告)号:US20210137938A1
公开(公告)日:2021-05-13
申请号:US17059297
申请日:2019-05-31
Applicant: INSTITUT NATIONAL DE SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO (ARAID) , MIGUEL HERNANDEZ UNIVERSITY OF ELCHE , FUNDACION INSTITUTO DE INVESTIGACION SANITARIA ARAGON , CHONGQING UNIVERSITY , INSTITUT JEAN PAOLI & IRENE CALMETES , UNIVERSITÉ D'AIX-MARSEILLE , UNIVERSITY OF ZARAGOZA , INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD - ARAGON INSTITUTE OF HEALTH SCIENCES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , CONSIGLIO NAZIONALE DELLE RICERCHE- NATIONAL RESEARCH COUNCIL ITALY
Inventor: Olga ABIAN FRANCO , Patricia SANTOFIMIA , Yi XIA , Jose Luis NEIRA , Bruno RIZZUTI , Adrian VELAZQUEZ CAMPOY , Ling PENG , Juan IOVANNA
IPC: A61K31/5415 , A61K45/06 , C07D279/28 , C07D417/12 , A61P35/00
Abstract: The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of formula (I) able to treat a variety of cancers by inhibiting NUPR1, a stress-inducible 82-amino-acid-long, intrinsically disordered member of the AT-hook family of chromatin proteins. Thus, the present invention relates to a compound of formula (I) for its use in the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer. In particular, the inventors tested compounds of formula (I) on four well characterized primary pancreatic cancer-derived cells 02.063 and LIPC (Basal subtype), Foic8b (derived from a liver metastasis) and HN14 (Classical subtype), as well as on other cellular lines derived from different tumors, i.e. U87 (glioblastoma), A375 and B16 (melanoma), U20S and SaOS (osteosarcoma), HT29, SK-CO-1 and LS174T (colon cancer), HepG2 (hepatocarcinoma), PC3 (prostate) and MDA-MB-231 (breast cancer). The compounds per se are also claimed.
-
公开(公告)号:US20210118576A1
公开(公告)日:2021-04-22
申请号:US17077294
申请日:2020-10-22
Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE
Inventor: Marco PELLEGRINI
IPC: G16H50/70 , G16B40/00 , G16B20/00 , G16H50/20 , G16H50/50 , G16H50/30 , G16H10/60 , G16H10/40 , G16H70/60
Abstract: Method for creating a coherent voting network including the steps of: a) organizing predetermined data from a cohort of patients in a master matrix having in its row the list of patients and having in its column the expression value of a panel of genes; b) applying a predetermined statistical test to each gene to evaluate which genes better discriminates survival or not-survival classes for patients, thus obtaining a first candidate panel of genes; c) discretizing the expression value of each of the genes belonging to said first candidate panel; d) converting the quantized master matrix in a first bipartite graph; e) applying a predetermined algorithm to the bipartite graph (G) to obtain a collection of bipartite communities; f) applying a predetermined algorithm to the communities, thus obtaining a second candidate panel; g) creating an updated bipartite graph comprising nodes-patients and nodes-gene whose genes belongs to the second candidate panel; h) repeating step e) on the updated bipartite graph; i) applying, at each community, a decision function on each patient belonging to it, to determine whether to assign her at the survival or not-survival class; j) checking, for each patient belonging to the various communities of step i), whether the class assigned is the same as the class of the master matrix; k) checking whether the percentage of coherent patients in the voting network is greater than a predetermined threshold, thus obtaining a coherent coting network.
-
公开(公告)号:US10980745B2
公开(公告)日:2021-04-20
申请号:US16590246
申请日:2019-10-01
Applicant: SIFI S.p.A. , Consiglio Nazionale delle Ricerche
Inventor: Elena Solfato , Ilenia Abbate , Cristina Maria Concetta Zappulla , Manuela Santonocito , Santa Viola , Sandro De Falco , Francesco Giuliano
IPC: A61K9/00 , A61K9/107 , A61P27/02 , A61K31/5575 , A61K31/05 , A61K31/44 , A61K47/44 , A61P27/04 , A61K47/14 , A61K47/10 , A61K47/12 , A61K47/26
Abstract: Provided are oil-in-water microemulsions for formulating pharmaceutically active compounds. The microemulsions contain oils, surfactants, water, and the pharmaceutical compounds, and are produced by mixing an aqueous phase and a lipid phase in which each phase contains at least one surfactant in a defined ratio whereby the resulting microemulsion has very small dispersed particles, and, is thermodynamically very stable.
-
公开(公告)号:US20210102838A1
公开(公告)日:2021-04-08
申请号:US16593781
申请日:2019-10-04
Inventor: Andrew N. Jordan , Francesco Giazotto , Sreenath K. Manikandan
Abstract: A heat transfer device and method are disclosed. The device includes a working region (i.e., working substance) made from a first superconducting material having a superconducting state and a normal state when magnetized. The first superconducting material has a first energy gap while in the superconducting state. A substrate (i.e., cold reservoir) is connected to the working region at a first tunnel junction. The substrate may be a metallic substrate. A heat sink (i.e., hot reservoir) is connected to the working region at a second tunnel junction. The heat sink is made from a second superconducting material having a second energy gap that is larger than the first energy gap. In a particular example, the heat transfer device includes a metallic substrate is made from Copper, a working region made from Tantalum, a heat sink made from Niobium, and the first and second tunnel junctions are made from Tantalum Oxide.
-
-
-
-
-
-
-
-
-