公开(公告)号：US20060036077A1

公开(公告)日：2006-02-16

申请号：US11243578

申请日：2005-10-05

申请人： Yueming Li ,  Min Xu ,  Qian Huang ,  Stephen Gardell

发明人： Yueming Li ,  Min Xu ,  Qian Huang ,  Stephen Gardell

IPC分类号： C07K14/47 ,  C12Q1/37

CPC分类号： C07H21/04 ,  C12Q1/37 ,  G01N2500/04 ,  G01N2800/2821

摘要： The present invention features γ-secretase substrates and in vitro assays for measuring γ-secretase activity employing such substrates. The γ-secretase substrates described herein contain a hydrophilic polypeptide moiety covalently joined to the carboxyl terminus of a β-CTF domain. A “β-CTF domain” is a polypeptide that can be cleaved by γ-secretase and which approximates the C-terminal fragment (amino acids 596-695) of APP produced after cleavage of APP by a β-secretase, or is a functional derivative thereof.

公开(公告)号：US06875435B2

公开(公告)日：2005-04-05

申请号：US09761534

申请日：2001-01-16

申请人： Qian Huang ,  Joan F. L. Richmond ,  Bryan K. Cho ,  Deborah Palliser ,  Jianzhu Chen ,  Herman N. Eisen ,  Richard A. Young

发明人： Qian Huang ,  Joan F. L. Richmond ,  Bryan K. Cho ,  Deborah Palliser ,  Jianzhu Chen ,  Herman N. Eisen ,  Richard A. Young

IPC分类号： A61K45/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/04 ,  A61K39/12 ,  A61K39/21 ,  A61K47/48 ,  A61P31/04 ,  A61P31/18 ,  A61P35/00 ,  A61P37/04 ,  C07K14/35 ,  A61K38/04 ,  A61K39/385

CPC分类号： C07K14/35 ,  A61K39/00 ,  A61K47/62 ,  A61K47/6425 ,  A61K2039/57 ,  C07K2319/00

摘要： The present invention relates to a method of inducing a CD8+ CTL response to a molecule in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. In one embodiment, the present invention relates to a method of treating HIV in an individual deficient in CD4+ T cells comprising administering to the individual an hsp or a portion of an ATP binding domain of an hsp joined to the molecule. Also encompassed by the present invention is a method of inducing a CD4+ independent CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. The present invention also relates to a method of inducing a CD8+ CTL response in an individual comprising administering to the individual a portion of an ATP binding domain of an hsp joined to the molecule. In addition, the present invention relates to a composition characterized by a portion of an ATP biding domain of an hsp joined to a molecule.

公开(公告)号：US06317710B1

公开(公告)日：2001-11-13

申请号：US09353192

申请日：1999-07-14

申请人： Qian Huang ,  Ivan Magrin-Chagnolleau ,  Sarangarajan Parthasarathy ,  Aaron Edward Rosenberg

发明人： Qian Huang ,  Ivan Magrin-Chagnolleau ,  Sarangarajan Parthasarathy ,  Aaron Edward Rosenberg

IPC分类号： G01L1700

CPC分类号： G10L17/00

摘要： A multimedia search apparatus and method for searching multimedia content using speaker detection to segment the multimedia content. The multimedia search apparatus receives a search request from a user device. The search request identifies the target speaker for which the search is to be conducted. Based on the search request, the multimedia search apparatus retrieves multimedia content from a multimedia database. The multimedia search apparatus retrieves models, such as Gaussian Mixture Models (GMMs), from a model storage device, corresponding to the target speaker and background data. Based on the retrieved models, the multimedia search device searches the audio data of the multimedia content and segments the audio data. The segments are identified by calculating an average normalized score for a block of frames of the audio data and determining if the average normalized score for the block of frames exceeds one or more predetermined thresholds.

摘要翻译： 一种多媒体搜索装置和方法，用于使用说话者检测来搜索多媒体内容来分割多媒体内容。 多媒体搜索装置从用户装置接收搜索请求。 搜索请求标识要进行搜索的目标扬声器。 基于搜索请求，多媒体搜索装置从多媒体数据库检索多媒体内容。 多媒体搜索装置从对应于目标说话者和背景数据的模型存储装置中检索诸如高斯混合模型（GMM）的模型。 基于所检索的模型，多媒体搜索装置搜索多媒体内容的音频数据并对音频数据进行分段。 通过计算音频数据的帧块的平均归一化分数并确定帧块的平均归一化分数是否超过一个或多个预定阈值来识别段。