公开(公告)号：US20170182015A1

公开(公告)日：2017-06-29

申请号：US15233860

申请日：2016-08-10

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Rachael E. Hawtin ,  Judith A. Fox

IPC: A61K31/4375 ,  C12Q1/68 ,  A61K45/06

CPC classification number: A61K31/4375 ,  A61K31/045 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  A61K2300/00

Abstract: Methods of using SNS-595 for treatment of a subject having cancer with BRCA2 mutation are described. In certain embodiments, the methods comprise administering a therapeutically effective amount of SNS-595 to a subject in need thereof.

公开(公告)号：US09676774B2

公开(公告)日：2017-06-13

申请号：US15156230

申请日：2016-05-16

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Daniel C. Adelman ,  Marc J. Evanchik ,  Anantha Sudhakar ,  Jeffrey William Jacobs ,  Jeffrey A. Silverman

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61K31/4745 ,  C07D417/14 ,  A61K2300/00

Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.

公开(公告)号：US20170114039A1

公开(公告)日：2017-04-27

申请号：US15167508

申请日：2016-05-27

Applicant: Biogen MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Xiongwei Cai ,  Timothy R. Chan ,  Patrick Conlon ,  Michael Humora ,  Tracy J. Jenkins ,  J. Michael Macphee ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: C07D401/14 ,  C07D401/04 ,  C07D207/16 ,  C07D211/56 ,  C07D207/28

CPC classification number: C07D401/14 ,  C07B2200/13 ,  C07D207/16 ,  C07D207/28 ,  C07D211/56 ,  C07D401/04

Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

公开(公告)号：US20160304494A1

公开(公告)日：2016-10-20

申请号：US15196389

申请日：2016-06-29

Applicant: Biogen MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Timothy R. Chan ,  Tracy J. Jenkins ,  Patrick Conlon ,  Xiongwei Cai ,  Michael Humora ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US09353087B2

公开(公告)日：2016-05-31

申请号：US14406081

申请日：2013-06-07

Applicant: Biogen Idec MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Xiongwei Cai ,  Timothy R. Chan ,  Patrick Conlon ,  Michael Humora ,  Tracy J. Jenkins ,  Michael J. Macphee ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: A61K31/506 ,  C07D401/14

CPC classification number: C07D401/14 ,  C07B2200/13 ,  C07D207/16 ,  C07D207/28 ,  C07D211/56 ,  C07D401/04

Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

Abstract translation: 本发明提供了一种化合物，固体形式及其组合物，其可用作Bruton酪氨酸激酶的抑制剂，并且其表现出对其的期望特性。 本发明还提供了制备所提供的化合物和固体形式的方法。

公开(公告)号：US09249146B2

公开(公告)日：2016-02-02

申请号：US14316710

申请日：2014-06-26

Applicant: Biogen Idec MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Minna Bui ,  Patrick Conlon ,  Julio H. Cuervo ,  Daniel A. Erlanson ,  Junfa Fan ,  Bing Guan ,  Brian T. Hopkins ,  Tracy J. Jenkins ,  Gnanasambandam Kumaravel ,  Alexey A. Lugovskoy ,  Doug Marcotte ,  Noel Powell ,  Daniel Scott ,  Laura Silvian ,  Art Taveras ,  Deping Wang ,  Min Zhong

IPC: C07D401/04 ,  A61K31/519 ,  C07D487/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/34

CPC classification number: C07D487/14 ,  A61K31/519 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04

Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。

公开(公告)号：US20150157614A1

公开(公告)日：2015-06-11

申请号：US14329765

申请日：2014-07-11

Applicant: Sunesis Pharmaceuticals, Inc.

Inventor： Anantha Sudhakar ,  Tamilarasan Subramani ,  Mohamed Sheik Mohamed Mujeebur Rahuman ,  Ramar Subbiah

IPC: A61K31/4375 ,  A61K47/10 ,  A61K47/20

CPC classification number: A61K31/4375 ,  A61K9/0019 ,  A61K9/08 ,  A61K45/06 ,  A61K47/10 ,  A61K47/20 ,  C07C59/245 ,  C07D207/16 ,  C07D471/04 ,  Y02P20/55

Abstract: Methods of preparing (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid are disclosed. Also provided are pharmaceutical compositions comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid, and methods of treatment using such compositions.

Abstract translation: 制备（+） - 1,4-二氢-7 - [（3S，4S）-3-甲氧基-4-（甲基氨基）-1-吡咯烷基] -4-氧代-1-（2-噻唑基）-1 ，8-萘啶-3-羧酸。 还提供了包含（+） - 1,4-二氢-7 - [（3S，4S）-3-甲氧基-4-（甲基氨基）-1-吡咯烷基] -4-氧代-1-（2-噻唑基 ）-1,8-萘啶-3-羧酸，以及使用这种组合物的处理方法。

公开(公告)号：US20150126528A1

公开(公告)日：2015-05-07

申请号：US14406081

申请日：2013-06-07

Applicant: Biogen Idec MA Inc. ,  Sunesis Pharmaceuticals, Inc.

Inventor： Brian T. Hopkins ,  Xiongwei Cai ,  Timothy R. Chan ,  Patrick Conlon ,  Michael Humora ,  Tracy J. Jenkins ,  Michael J. Macphee ,  Xianglin Shi ,  Ross A. Miller ,  Andrew Thompson

IPC: C07D401/14

CPC classification number: C07D401/14 ,  C07B2200/13 ,  C07D207/16 ,  C07D207/28 ,  C07D211/56 ,  C07D401/04

Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

Abstract translation: 本发明提供了一种化合物，固体形式及其组合物，其可用作Bruton酪氨酸激酶的抑制剂，并且其表现出对其的期望特性。 本发明还提供了制备所提供的化合物和固体形式的方法。

公开(公告)号：US20140275547A1

公开(公告)日：2014-09-18

申请号：US14055590

申请日：2013-10-16

Applicant: SUNESIS PHARMACEUTICALS, INC.

Inventor： Anantha Sudhakar ,  Jeff Jacobs ,  Ahmad Hashash ,  Sean Ritchie ,  Henggin Cheng

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4375 ,  C07D417/04 ,  C07D417/14

Abstract: Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles.

Abstract translation: 公开了制备基本上纯的SNS-595物质的方法。 还提供了包含基本上纯的且基本上不含可见颗粒的SNS-595物质的组合物。

公开(公告)号：US20130065858A1

公开(公告)日：2013-03-14

申请号：US13657506

申请日：2012-10-22

Applicant: MILLENNIUM PHARMACEUTICALS, INC. ,  SUNESIS PHARMACEUTICALS, INC.

Inventor： Weirong Chen ,  Jennifer Cossrow ,  Lloyd Franklin ,  Bing Guan ,  John Howard Jones ,  Gnanasambandam Kumaravel ,  Benjamin Lane ,  Adam Littke ,  Alexey Lugovskoy ,  Hairuo Peng ,  Noel Powell ,  Brian C. Raimundo ,  Hiroko Tanaka ,  Jeffrey Vessels ,  Thomas Wynn ,  Zhili Xin

IPC: A61K31/506 ,  C07D417/14 ,  A61K31/5377 ,  C07D417/12 ,  C07D413/14 ,  C07D473/00 ,  A61K31/52 ,  C07D471/04 ,  C07F9/6558 ,  A61K31/675 ,  A61K31/541 ,  A61P35/00 ,  A61P31/00 ,  A61P29/00 ,  A61P37/02 ,  A61P25/00 ,  A61P9/00 ,  A61P19/08 ,  A61P1/16 ,  A61P31/12 ,  A61P7/00 ,  A61P3/10 ,  C07D401/14

CPC classification number: C07D417/14 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07F9/65583

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.