公开(公告)号：US11049795B2

公开(公告)日：2021-06-29

申请号：US16481634

申请日：2018-01-29

申请人： Supergrid Institute ,  Universite Claude Bernard Lyon 1 ,  Ecole Centrale De Lyon ,  Institut National Des Sciences Appliquees De Lyon ,  Centre National De La Recherche Scientifique

发明人： Cyril Buttay

IPC分类号： H01L23/427 ,  H01L23/22 ,  H01L23/24 ,  H01L23/473

摘要： A power electronic module (1) including at least one semiconductor (5) that is connected to connection conductors (6, 7), and including a dielectric carrier (10) having both a fixed layer (9), on which at least one of said connection conductors (6) is mounted, and a movable layer (11), the fixed layer (9) and the movable layer (11) exhibiting similar dielectric permittivities and being superposed along at least one surface facing the at least one connection conductor (6).

公开(公告)号：US20210154205A1

公开(公告)日：2021-05-27

申请号：US17057141

申请日：2019-05-23

申请人： UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE NORMALE SUPERIEURE DE LYON ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE LAVAL

发明人： Manuel ROSA-CALATRAVA ,  Olivier TERRIER ,  Claire NICOLAS DE LAMBALLERIE ,  Guy BOIVIN ,  Mario Andres PIZZORNO

IPC分类号： A61K31/554 ,  A61K45/06 ,  A61P37/04 ,  A61P31/14 ,  A61P31/04

摘要： The present invention relates to diltiazem for use as an agent for activating the expression of at least one gene encoding a type III interferon, in the prevention and/or treatment of infections by at least one pathogenic microorganism of the epithelia of the respiratory and/or intestinal tracts.

公开(公告)号：US20210024673A1

公开(公告)日：2021-01-28

申请号：US16872313

申请日：2020-05-11

申请人： SOLVAY SA ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITE CLAUDE BERNARD LYON 1

发明人： Jerome VINAS ,  Emilie VELASQUEZ ,  Pierre-Emmanuel DUFILS ,  Jutta RIEGER ,  François STOFFELBACH ,  Muriel LANSALOT ,  Franck D'AGOSTO ,  Bernadette CHARLEUX ,  Yves VANDERVEKEN

IPC分类号： C08F214/08 ,  C08G81/02 ,  C08J5/18 ,  C09D127/22

摘要： Process for the preparation of a vinylidene chloride polymer comprising polymerizing vinylidene chloride and optionally at least one ethylenically unsaturated monomer copolymerizable therewith under the control of a RAFT agent of formula (II).

公开(公告)号：US20200261597A1

公开(公告)日：2020-08-20

申请号：US16776642

申请日：2020-01-30

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ENS - ECOLE NORMALE SUPERIEURE DE LYON ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  HOSPICE CIVILS DE LYON

发明人： Antoine SICARD ,  Olivier THAUNAT

IPC分类号： A61K47/69 ,  A61K39/39 ,  A61K39/12 ,  A61K39/00 ,  C12N7/00 ,  A61K39/21 ,  A61K47/68

摘要： The present invention relates to biofunctionalized nanoparticles and uses thereof in adoptive cell therapy. In particular, the present invention relates to a nanoparticle comprising an amount of at least one antigen and an amount of at least one antibody having specificity for a B cell receptor wherein the antigen and antibody are attached to the surface of the nanoparticle.

公开(公告)号：US10745482B2

公开(公告)日：2020-08-18

申请号：US16533038

申请日：2019-08-06

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  UNIVERSITE D'AIX-MARSEILLE ,  Universite Claude Bernard—Lyon 1 ,  Centre Leon Berard

发明人： Julien Faget ,  Christophe Caux ,  Christine Menetrier-Caux ,  Jacques Nunes ,  Daniel Olive

IPC分类号： C07K16/28 ,  A61K39/395 ,  G01N33/569 ,  G01N33/574 ,  A61K39/00

摘要： The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4− T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

公开(公告)号：US20200237956A1

公开(公告)日：2020-07-30

申请号：US16845422

申请日：2020-04-10

申请人： Bioxis Pharmaceuticals ,  Universite Jean Monnet ,  Institut National des Sciences Appliquees de Lyon ,  Universite Claude Bernard Lyon 1 ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Florence Dupasquier ,  Laurent David ,  Thierry Delair

IPC分类号： A61L27/20 ,  A61K8/73 ,  A61Q19/08 ,  A61L24/08 ,  A61L31/04 ,  A61L27/54 ,  A61L27/58

摘要： The present invention relates to a homogeneous aqueous solution of injectable chitosan containing a chitosan having a degree of acetylation lower than 20%, said solution containing between 0.1 and 3.5% by weight of chitosan, said solution presenting a pH lower than 6.2, and said aqueous solution being capable of forming crystalline particles of chitosan after injection. The present invention also relates to compounds containing such a homogeneous aqueous solution of chitosan. The invention also relates to such compounds for their use as dermatological or cosmetic compounds, or for their use as a medical device, advantageously as a bioresorbable implant.

公开(公告)号：US10695753B2

公开(公告)日：2020-06-30

申请号：US15518931

申请日：2015-10-06

申请人： Centre National de la Recherche Scientifique ,  Universite Claude Bernard—Lyon 1 ,  IFP Energies Nouvelles

发明人： Dina Lofficial ,  Antoine Fecant ,  Denis Uzio ,  Eric Puzenat ,  Christophe Geantet

IPC分类号： B01J23/26 ,  B01J23/66 ,  B01J37/03 ,  B01J37/34 ,  B01J23/62 ,  B01J35/00 ,  C01B3/26 ,  C01B3/22 ,  B01J35/02 ,  B01J37/00 ,  B01J37/04 ,  B01J37/06 ,  B01J37/08

摘要： The invention relates to a composition that contains a first semiconductor SC1, particles that comprise one or more element(s) M in the metal state selected from among an element of groups IVB, VB, VIB, VIIB, VIIIB, IB, IIB, IIIA, IVA and VA of the periodic table, and a second semiconductor SC2 that comprises indium oxide, with said first semiconductor SC1 being in direct contact with said particles that comprise one or more element(s) M in the metal state, with said particles being in direct contact with said second semiconductor SC2 that comprises indium oxide in such a way that the second semiconductor SC2 covers at least 50% of the surfaces of the particles that comprise one or more element(s) M in the metal state. The invention also relates to its preparation method as well as its application of photocatalysis.

公开(公告)号：US10682630B2

公开(公告)日：2020-06-16

申请号：US15518967

申请日：2015-10-06

申请人： IFP ENERGIES NOUVELLES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE CLAUDE BERNARD—LYON 1

发明人： Dina Lofficial ,  Antoine Fecant ,  Denis Uzio ,  Eric Puzenat ,  Christophe Geantet

IPC分类号： B01J23/63 ,  B01J37/03 ,  B01J37/34 ,  B01J23/66 ,  B01J35/00 ,  B01J23/83 ,  C01B3/26 ,  C01B3/22

摘要： The invention relates to a composition that contains a first semiconductor SC1, particles that comprise one or more element(s) M in the metal state selected from among an element of groups IVB, VB, VIB, VIIB, VIIIB, IB, IIB, IIIA, IVA and VA of the periodic table, and a second semiconductor SC2 that comprises cerium oxide, with said first semiconductor SC1 being in direct contact with said particles that comprise one or more element(s) M in the metal state, with said particles being in direct contact with said second semiconductor SC2 that comprises cerium oxide in such a way that the second semiconductor SC2 covers at least 50% of the surfaces of the particles that comprise one or more element(s) M in the metal state. The invention also relates to its preparation method as well as its application of photocatalysis.

公开(公告)号：US10533046B2

公开(公告)日：2020-01-14

申请号：US15502469

申请日：2015-08-10

申请人： INTERNATIONAL—DRUG—DEVELOPMENT—BIOTECH ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  HOSPICES CIVILS DE LYON ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE LEON BERARD

发明人： Marie Alexandra Albaret ,  Jean-Jacques Diaz ,  Hichem Claude Mertani ,  Jean-Christophe Saurin ,  Claudine Vermot-Desroches ,  Boris Vuillermoz

IPC分类号： C07K16/18 ,  C07K16/30 ,  A61P35/00 ,  A61K39/395 ,  C07K7/06 ,  A61K39/00 ,  A61K45/06 ,  G01N33/574

摘要： The present disclosure relates to a human CK8 antigen peptide, an antibody, or antibody fragment thereof, or a humanized antibody, specifically binding the peptide having the amino acid sequence of SEQ ID No. 29, a fragment of CK-8. Said molecules can be used use in the detection and/or treatment of tumors whose cells express CK8 protein, in particular the peptide of sequence according to SEQ ID No.29, on their surface.

公开(公告)号：US20190390362A1

公开(公告)日：2019-12-26

申请号：US16471032

申请日：2017-12-19

申请人： TOTAL RAFFINAGE CHIMIE ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON (INSA LYON) ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Christel Augustin ,  Sophie Cazottes ,  Nicolas Vaché ,  Philippe Steyer ,  Claude Duret Thual ,  François Dupoiron

IPC分类号： C25F3/06 ,  C23C8/02 ,  B24C1/04

摘要： The invention relates to a process for the treatment of a wall made of Fe—Ni—Cr metal alloy of an industrial reactor which reduces the formation of coke on the said wall when it is subjected to operational conditions favourable to coking, the metal alloy comprising, within its structure, carbides, some of which show on the surface. The process comprises a chemical surface treatment stage, during which at least a part of the carbides initially present in the alloy is dissolved by electrolytic decomposition, under conditions suitable for dissolving at least a part of these carbides, in particular chromium carbides.