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公开(公告)号:US20070224189A1
公开(公告)日:2007-09-27
申请号:US11618457
申请日:2006-12-29
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to CD20 optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及CD20优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US20070202098A1
公开(公告)日:2007-08-30
申请号:US11618488
申请日:2006-12-29
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to Her2/neu optimized Sc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及Her2 / neu优化的Sc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US20070160597A1
公开(公告)日:2007-07-12
申请号:US11483378
申请日:2006-07-07
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号:US20070053901A1
公开(公告)日:2007-03-08
申请号:US11495242
申请日:2006-07-27
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US08961967B2
公开(公告)日:2015-02-24
申请号:US12955240
申请日:2010-11-29
申请人: William Strohl , Omid Vafa
发明人: William Strohl , Omid Vafa
CPC分类号: C07K16/32 , A61K38/00 , A61K2039/505 , C07K16/00 , C07K16/2887 , C07K2317/52 , C07K2317/524 , C07K2317/54 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要: Antibody and other Fc-containing molecules with variations in the Fc region reduce binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.
摘要翻译: 具有Fc区变化的抗体和其它含Fc的分子减少与Fcγ受体的结合并导致其活性,并可用于治疗各种疾病和病症。
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公开(公告)号:US20070243188A1
公开(公告)日:2007-10-18
申请号:US11766596
申请日:2007-06-21
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having decreased affinity for FcγRIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIa的亲和力降低的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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公开(公告)号:US20070238665A1
公开(公告)日:2007-10-11
申请号:US11765378
申请日:2007-06-19
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having decreased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及具有降低的FcγRIIc亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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公开(公告)号:US20070237765A1
公开(公告)日:2007-10-11
申请号:US11765390
申请日:2007-06-19
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having Increased affinity for FcγRI, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRRI具有增加亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽和使用优化的Fc变体的方法。
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公开(公告)号:US20060134105A1
公开(公告)日:2006-06-22
申请号:US11256060
申请日:2005-10-21
申请人: Gregory Lazar , Bassil Dahiyat , Wei Dang , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Bassil Dahiyat , Wei Dang , Sher Karki , Omid Vafa
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: C07K16/00 , C07K16/2878 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
摘要翻译: 本申请涉及优化的IgG免疫球蛋白变体,其产生的工程方法及其应用,特别是用于治疗目的。
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公开(公告)号:US20110212087A1
公开(公告)日:2011-09-01
申请号:US12955240
申请日:2010-11-29
申请人: William Strohl , Omid Vafa
发明人: William Strohl , Omid Vafa
CPC分类号: C07K16/32 , A61K38/00 , A61K2039/505 , C07K16/00 , C07K16/2887 , C07K2317/52 , C07K2317/524 , C07K2317/54 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要: Antibody and other Fc-containing molecules with variations in the Fc region reduce binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.
摘要翻译: 具有Fc区变化的抗体和其它含Fc的分子减少与Fcγ受体的结合并导致其活性,并可用于治疗各种疾病和病症。
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