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公开(公告)号:US20090053211A9
公开(公告)日:2009-02-26
申请号:US11124620
申请日:2005-05-05
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/2893 , C07K2317/34 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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公开(公告)号:US20060160996A9
公开(公告)日:2006-07-20
申请号:US10822231
申请日:2004-03-26
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
IPC分类号: C07K16/44
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号:US20080051563A1
公开(公告)日:2008-02-28
申请号:US11841821
申请日:2007-08-20
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
IPC分类号: C07K16/18
CPC分类号: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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公开(公告)号:US20070224192A1
公开(公告)日:2007-09-27
申请号:US11747804
申请日:2007-05-11
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US20070219133A1
公开(公告)日:2007-09-20
申请号:US11618472
申请日:2006-12-29
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to CD52 optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及CD52优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US20070003546A1
公开(公告)日:2007-01-04
申请号:US11483250
申请日:2006-07-07
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号:US20060024298A1
公开(公告)日:2006-02-02
申请号:US11124620
申请日:2005-05-05
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/2893 , C07K2317/34 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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公开(公告)号:US20050054832A1
公开(公告)日:2005-03-10
申请号:US10822231
申请日:2004-03-26
申请人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
发明人: Gregory Lazar , Arthur Chirino , Wei Dang , John Desjarlais , Stephen Doberstein , Robert Hayes , Sher Karki , Omid Vafa
CPC分类号: C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译: 本发明涉及优化的Fc变体,其产生方法,以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号:US20070243188A1
公开(公告)日:2007-10-18
申请号:US11766596
申请日:2007-06-21
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having decreased affinity for FcγRIIa, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及对FcγRIIa的亲和力降低的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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公开(公告)号:US20070238665A1
公开(公告)日:2007-10-11
申请号:US11765378
申请日:2007-06-19
申请人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
发明人: Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要: The present invention relates to Fc variants having decreased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
摘要翻译: 本发明涉及具有降低的FcγRIIc亲和力的Fc变体,其产生方法,包含优化的Fc变体的Fc多肽,以及使用优化的Fc变体的方法。
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