公开(公告)号：US08466323B2

公开(公告)日：2013-06-18

申请号：US13141016

申请日：2009-12-10

申请人： Johann-Peter Melder ,  Gunther Van Cauwenberge ,  Tom Fremau ,  Jürgen Moors ,  Thilo Hahn ,  Bernd Stein

发明人： Johann-Peter Melder ,  Gunther Van Cauwenberge ,  Tom Fremau ,  Jürgen Moors ,  Thilo Hahn ,  Bernd Stein

IPC分类号： C07C209/84 ,  C07C209/86

CPC分类号： C07C213/10 ,  C07C215/12

摘要： A process for preparing pure triethanolamine (TEOA) by continuously distillatively separating an ethanolamine mixture comprising TEOA and diethanolamine (DEOA), by distilling off DEOA in a distillation column (DEOA column) and supplying the resulting bottom stream comprising TEOA to a downstream column (TEOA column) in which the pure TEOA is withdrawn as a side draw stream, wherein the residence time of the ethanolamine mixture in the bottom of the DEOA column is

摘要翻译： 通过在蒸馏塔（DEOA柱）中蒸馏除去DEOA并将得到的包含TEOA的底部物流供应到下游塔（TEOA）中，通过连续蒸馏分离包含TEOA和二乙醇胺（DEOA）的乙醇胺混合物来制备纯三乙醇胺（TEOA） 柱），其中作为侧馏分流取出纯TEOA，其中乙醇胺混合物在DEOA塔底部的停留时间<20分钟。

公开(公告)号：US20130038115A1

公开(公告)日：2013-02-14

申请号：US13641152

申请日：2011-03-18

申请人： Bernd Stein ,  Bernhard Rees ,  Ingo Kumpf ,  Florian Kiefer

发明人： Bernd Stein ,  Bernhard Rees ,  Ingo Kumpf ,  Florian Kiefer

IPC分类号： A46D3/00

CPC分类号： A46D3/045 ,  A46D1/08 ,  A46D3/04

摘要： An apparatus (1) for producing bristle arrangements for brushes, in particular toothbrushes, having a bristle supply (2) and an apparatus (3) for extracting individual bundles (4) of bristles from the bristle supply (2), and also having a transporting apparatus for transporting the bundles (4) of bristles by way of at least one hollow line (8) by means of a stream of gas or air in perforations in a bundle-retaining plate, is characterized in that the apparatus (3) for extracting the bundles (4) of bristles from the bristle supply (2) has at least one bundle holder (6), and in that the bundle holder(s) (6) of the extraction means (3), the inner contour (10) of the hollow line(s) (8) and the perforations in the bundle-retaining plate are each contoured in a manner corresponding to the bundle contour which is desired in the bristle arrangement.

摘要翻译： 一种用于制造用于刷子的刷毛装置的设备（1），特别是具有刷毛供应装置（2）的刷子和用于从刷毛供应装置（2）提取单个束（4）的刷毛的装置（3），并且还具有 用于通过至少一个空心线（8）通过束保持板中的穿孔中的气体或空气流输送刷毛束（4）的输送装置的特征在于，用于 从刷毛供应装置（2）提取刷毛束（4）具有至少一个捆扎架（6），并且提取装置（3）的束夹持器（6），内轮廓（10） ）和中空线（8）中的穿孔和束保持板中的穿孔各自以对应于刷毛布置中期望的束轮廓的方式进行轮廓。

公开(公告)号：US20120264979A1

公开(公告)日：2012-10-18

申请号：US13421249

申请日：2012-03-15

申请人： Frank-Friedrich Pape ,  Alfred Krause ,  Johann-Peter Melder ,  Bernd Stein ,  Joachim-Thierry Anders ,  Frank Haese

发明人： Frank-Friedrich Pape ,  Alfred Krause ,  Johann-Peter Melder ,  Bernd Stein ,  Joachim-Thierry Anders ,  Frank Haese

IPC分类号： C07C209/68 ,  B01J19/00

CPC分类号： C07C213/04 ,  B01J2219/00006 ,  C07C217/08

摘要： A process for preparing N,N-dimethylaminoethoxyethanol (DMAEE), wherein a) dimethylamine and ethylene oxide are reacted, b) the resulting product mixture of N,N-dimethylethanolamine and DMAEE is separated by distillation to obtain a DMAEE-containing fraction as the bottom stream, and c) DMAEE from the fraction obtained in (b) is removed by distillation.

摘要翻译： 制备N，N-二甲基氨基乙氧基乙醇（DMAEE）的方法，其中a）二甲基胺和环氧乙烷反应，b）通过蒸馏分离得到的N，N-二甲基乙醇胺和DMAEE的所得产物混合物，得到含DMAEE的级分 底部流，和c）通过蒸馏除去（b）中获得的级分的DMAEE。

公开(公告)号：US20110257437A1

公开(公告)日：2011-10-20

申请号：US13141016

申请日：2009-12-10

申请人： Johann-Peter Melder ,  Gunther Van Cauwenberge ,  Tom Fremau ,  Jürgen Moors ,  Thilo Hahn ,  Bernd Stein

发明人： Johann-Peter Melder ,  Gunther Van Cauwenberge ,  Tom Fremau ,  Jürgen Moors ,  Thilo Hahn ,  Bernd Stein

IPC分类号： C07C209/86

CPC分类号： C07C213/10 ,  C07C215/12

摘要： A process for preparing pure triethanolamine (TEOA) by continuously distillatively separating an ethanolamine mixture comprising TEOA and diethanolamine (DEOA), by distilling off DEOA in a distillation column (DEOA column) and supplying the resulting bottom stream comprising TEOA to a downstream column (TEOA column) in which the pure TEOA is withdrawn as a side draw stream, wherein the residence time of the ethanolamine mixture in the bottom of the DEOA column is

摘要翻译： 通过在蒸馏塔（DEOA柱）中蒸馏除去DEOA并将得到的包含TEOA的底部物流供应到下游塔（TEOA）中，通过连续蒸馏分离包含TEOA和二乙醇胺（DEOA）的乙醇胺混合物来制备纯三乙醇胺（TEOA） 柱），其中作为侧馏分流取出纯TEOA，其中乙醇胺混合物在DEOA塔底部的停留时间<20分钟。

公开(公告)号：US20110251433A1

公开(公告)日：2011-10-13

申请号：US13080080

申请日：2011-04-05

申请人： Christof Wilhelm WIGBERS ,  Christoph Müller ,  Johann-Peter Melder ,  Bernd Stein ,  Harald Meißner ,  Gerd Haderlein ,  Norbert Gutfrucht

发明人： Christof Wilhelm WIGBERS ,  Christoph Müller ,  Johann-Peter Melder ,  Bernd Stein ,  Harald Meißner ,  Gerd Haderlein ,  Norbert Gutfrucht

IPC分类号： C07C209/00

CPC分类号： C07C209/26 ,  Y02P20/582 ,  C07C211/17 ,  C07C211/08

摘要： The present application relates to a process for preparing unsymmetric secondary tert-butylamines which, as well as the tert-butyl radical, also comprise an alkyl, cycloalkyl or benzyl radical. They are prepared by reacting corresponding aldehydes with tert-butylamine and hydrogen in the presence of hydrogenation catalysts (reductive amination) in the liquid phase.

摘要翻译： 本申请涉及一种制备不对称仲叔丁胺的方法，其中叔丁基以及叔丁基也包括烷基，环烷基或苄基。 它们通过在液相中的氢化催化剂（还原胺化）存在下，使相应的醛与叔丁胺和氢反应来制备。

公开(公告)号：US20110184210A1

公开(公告)日：2011-07-28

申请号：US13082030

申请日：2011-04-07

申请人： Marco Bosch ,  Roderich Röttger ,  Bernd Stein ,  Thomas Krug ,  Johann-Peter Melder ,  Theodor Weber

发明人： Marco Bosch ,  Roderich Röttger ,  Bernd Stein ,  Thomas Krug ,  Johann-Peter Melder ,  Theodor Weber

IPC分类号： C07C209/60

CPC分类号： C07C209/16 ,  B01J8/0221 ,  B01J8/0285 ,  B01J2208/00132 ,  B01J2208/00353 ,  B01J2208/0053 ,  C07C211/04

摘要： In the continuous process for preparing alkylamines by reacting C1-4-alkanols with ammonia in the gas phase in the presence of a shape-selective fixed-bed catalyst in a cooled reactor, the shape-selective fixed-bed catalyst is present in a single contiguous fixed bed in the reactor and tubes through which coolants are passed run within the fixed bed to regulate the temperature of the fixed bed.

摘要翻译： 在冷却的反应器中，在形状选择性固定床催化剂存在下，在气相中使C 1-4 - 链烷醇与氨反应制备烷基胺的连续方法中，形状选择性固定床催化剂存在于单一 反应器中连续的固定床和冷却剂通过的管通过固定床内以调节固定床的温度。

公开(公告)号：US07951974B2

公开(公告)日：2011-05-31

申请号：US12771414

申请日：2010-04-30

申请人： Marco Bosch ,  Roderich Röttger ,  Bernd Stein ,  Thomas Krug ,  Johann-Peter Melder ,  Theodor Weber

发明人： Marco Bosch ,  Roderich Röttger ,  Bernd Stein ,  Thomas Krug ,  Johann-Peter Melder ,  Theodor Weber

IPC分类号： C07C209/16

CPC分类号： C07C209/16 ,  B01J8/0221 ,  B01J8/0285 ,  B01J2208/00132 ,  B01J2208/00353 ,  B01J2208/0053 ,  C07C211/04

摘要： In the continuous process for preparing alkylamines by reacting C1-4-alkanols with ammonia in the gas phase in the presence of a shape-selective fixed-bed catalyst in a cooled reactor, the shape-selective fixed-bed catalyst is present in a single contiguous fixed bed in the reactor and tubes through which coolants are passed run within the fixed bed to regulate the temperature of the fixed bed.

摘要翻译： 在冷却的反应器中，在形状选择性固定床催化剂存在下，在气相中使C 1-4 - 链烷醇与氨反应制备烷基胺的连续方法中，形状选择性固定床催化剂存在于单一 反应器中连续的固定床和冷却剂通过的管通过固定床内以调节固定床的温度。

公开(公告)号：US20100210877A1

公开(公告)日：2010-08-19

申请号：US12771414

申请日：2010-04-30

申请人： Marco Bosch ,  Roderich Röttger ,  Bernd Stein ,  Thomas Krug ,  Johann-Peter Melder ,  Theodor Weber

发明人： Marco Bosch ,  Roderich Röttger ,  Bernd Stein ,  Thomas Krug ,  Johann-Peter Melder ,  Theodor Weber

IPC分类号： C07C209/16

CPC分类号： C07C209/16 ,  B01J8/0221 ,  B01J8/0285 ,  B01J2208/00132 ,  B01J2208/00353 ,  B01J2208/0053 ,  C07C211/04

摘要： In the continuous process for preparing alkylamines by reacting C1-4-alkanols with ammonia in the gas phase in the presence of a shape-selective fixed-bed catalyst in a cooled reactor, the shape-selective fixed-bed catalyst is present in a single contiguous fixed bed in the reactor and tubes through which coolants are passed run within the fixed bed to regulate the temperature of the fixed bed.

摘要翻译： 在冷却的反应器中，在形状选择性固定床催化剂存在下，在气相中使C 1-4 - 链烷醇与氨反应制备烷基胺的连续方法中，形状选择性固定床催化剂存在于单一 反应器中连续的固定床和冷却剂通过的管通过固定床内以调节固定床的温度。

公开(公告)号：US07504090B2

公开(公告)日：2009-03-17

申请号：US11439084

申请日：2006-05-23

申请人： Bernd Stein ,  Michael Franzke ,  Sabine Baecker

发明人： Bernd Stein ,  Michael Franzke ,  Sabine Baecker

IPC分类号： A61Q5/00 ,  A61K8/00 ,  A61K8/02 ,  A61K8/18

CPC分类号： A61Q5/06 ,  A61K8/046 ,  A61K8/31 ,  A61K8/37 ,  A61K8/375 ,  A61K8/39 ,  A61K8/553 ,  A61K8/556 ,  A61K8/585 ,  A61K8/8105 ,  A61K8/8111 ,  A61K8/92 ,  A61K8/922 ,  A61K8/925 ,  A61K8/927 ,  Y10S424/01 ,  Y10S514/945

摘要： The wax product for treating or setting up a hairstyle or hairdo includes a composition containing at least one wax or wax-like substance, at least one non-volatile liquid hydrophobic oil and at least one volatile or easily volatilized hydrophobic substance that is a liquid or gas at room temperature. Because of the presence of the volatile substance in the composition a soft wax easily worked in the hair is obtained when the composition is applied to the hair. This soft wax hardens on the hair when the volatile ingredients evaporate. When the composition includes a propellant gas a wax with a larger surface area (wax snow) is produced, which is likewise easily worked into the hair and very effectively fixes or sets the hair.

公开(公告)号：US20070149571A1

公开(公告)日：2007-06-28

申请号：US11704665

申请日：2007-02-09

申请人： Bernd Stein ,  John Westwick ,  Bruce Ennis

发明人： Bernd Stein ,  John Westwick ,  Bruce Ennis

IPC分类号： A61K31/454

CPC分类号： A61K31/704 ,  A61K31/337 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/505 ,  A61K31/513 ,  A61K31/675 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective amount of one or more inhibitors of JNK in combination with the administration of an effective amount of one or more other agents useful for cancer therapy. The invention also provides pharmaceutical compositions comprising one or more inhibitors of JNK in combination with one or more other agents useful for cancer therapy. In particular, the invention is directed to methods of treatment and prevention of cancer by the administration of an effective amount of one or more inhibitors of JNK in combination with standard and experimental chemotherapies, hormonal therapies, bone marrow transplants, stem cell replacement therapies, biological therapies/immunotherapies and/or radiation therapies for treatment or prevention of cancer. Also included are methods of treatment of cancer by the administration of one or more inhibitors of JNK in combination with surgery, alone or in further combination with standard and experimental chemotherapies, hormonal therapies, bone marrow transplants, stem cell replacement therapies, biological therapies/immunotherapies and/or radiation therapies.

摘要翻译： 本发明涉及设计用于治疗，管理或预防癌症的方法和组合物。 本发明的方法包括施用有效量的一种或多种JNK抑制剂与施用有效量的一种或多种其它可用于癌症治疗的试剂的组合。 本发明还提供包含一种或多种JNK抑制剂与一种或多种其它可用于癌症治疗的试剂组合的药物组合物。 特别地，本发明涉及通过给予有效量的一种或多种JNK抑制剂与标准和实验化学疗法，激素疗法，骨髓移植物，干细胞替代疗法，生物学方法，治疗和预防癌症的方法 用于治疗或预防癌症的治疗/免疫治疗和/或放射疗法。 还包括通过单独或与标准和实验化疗，激素治疗，骨髓移植，干细胞替代疗法，生物疗法/免疫疗法单独或进一步组合的一种或多种JNK抑制剂的给药来治疗癌症的方法 和/或放射疗法。