公开(公告)号：US12071391B2

公开(公告)日：2024-08-27

申请号：US18128536

申请日：2023-03-30

申请人： Atossa Therapeutics, Inc.

发明人： Steven C. Quay ,  Yao-Lin Sun ,  LungHu Wang ,  ChangJung Wu ,  ChuanDer Huang

IPC分类号： A61K31/135 ,  C07C213/10 ,  C07C217/18 ,  A61K9/00 ,  A61K45/06

CPC分类号： C07C217/18 ,  C07C213/10 ,  A61K9/0053 ,  A61K45/06 ,  C07B2200/13

摘要： The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

公开(公告)号：US20240083837A1

公开(公告)日：2024-03-14

申请号：US18264127

申请日：2021-05-19

申请人： Dow Global Technologies LLC ,  Dow Chemical Korea Limited

发明人： Qi Jiang ,  Kaoru Ohba ,  Yujun Liu ,  Jongcheol Kim ,  Xue Chen ,  Li Mu

IPC分类号： C07C213/10 ,  B01D15/36

CPC分类号： C07C213/10 ,  B01D15/362 ,  B01D15/363

摘要： It is related to a process for purifying organic amines. The process comprises (a) providing an organic amine to a first vessel (5), the organic amine having a normal boiling point at one bar; (b) filling the first vessel (5) with inert gas; (c) heating the organic amine in the first vessel (5) to a sub-boiling temperature, wherein the sub-boiling temperature is at least 15° C. less than the normal boiling point; (d) cooling the vapor from the first vessel (5) in a second vessel (20) to provide a liquid; and (e) contacting the organic amine with a resin polymer matrix, wherein the resin polymer matrix is embedded with an amino compound selected from the group consisting of iminodiacetic acid, aminomethylphosphonic acid or a combination thereof.

公开(公告)号：US20230373904A1

公开(公告)日：2023-11-23

申请号：US18203678

申请日：2023-05-31

申请人： Radius Pharmaceuticals, Inc.

发明人： Michael Paul Cruskie, JR. ,  Joshua Kyle Bolger ,  Jonathan Blake McKenzie ,  Pratik Sheth ,  Richard Edwards ,  Alex Eberlin ,  Michael Markey

IPC分类号： C07C217/84 ,  A61P35/00 ,  C07C213/10

CPC分类号： C07C217/84 ,  A61P35/00 ,  C07C213/10 ,  C07B2200/13

摘要： Various polymorphic forms of RAD1901-2HCl, including three crystalline and amorphous forms, are prepared and characterized. Uses of the various polymorphic forms of RAD1901-2HCl for cancer treatment are also disclosed.

公开(公告)号：US11760716B2

公开(公告)日：2023-09-19

申请号：US17262710

申请日：2019-07-23

申请人： SPACEPHARMA R&D ISRAEL LTD.

发明人： Guy Samburski ,  Shimon Amselem

IPC分类号： C07C213/10 ,  C07B63/00

CPC分类号： C07C213/10 ,  C07B63/00 ,  C07B2200/13

摘要： Disclosed is a method for crystallizing molecules having a molecular weight equal to or lower than about 500 Dalton in a gravity below about 0.01 g to about 0.000001 g as well as to crystalline molecules having a molecular weight equal to, or lower than, about 500 Dalton, prepared under microgravity conditions.

公开(公告)号：US11643384B2

公开(公告)日：2023-05-09

申请号：US16961231

申请日：2018-04-26

申请人： KURITA WATER INDUSTRIES LTD.

发明人： Michael Urschey ,  Tim Rudolph

IPC分类号： C07C213/10 ,  C02F5/12 ,  C10G75/02 ,  C10G75/04 ,  C23F11/14 ,  G03F7/42

CPC分类号： C07C213/10 ,  C02F5/12 ,  C10G75/02 ,  C10G75/04 ,  C23F11/141 ,  G03F7/425 ,  C02F2303/08

摘要： A composition comprising a) a quaternary trialkylalkanolamine hydroxide and b) at least one diamine as component b), which is selected from the group consisting of 1-amino-4-methylpiperazine, 1,2-diaminopropane and mixtures thereof.

公开(公告)号：US20180370898A1

公开(公告)日：2018-12-27

申请号：US16060309

申请日：2016-12-06

申请人： SABIC GLOBAL TECHNOLOGIES B.V.

发明人： FENG XU ,  FLAIYH AL-ANAZI

IPC分类号： C07C213/10 ,  C07F5/02

CPC分类号： C07C213/10 ,  C07D215/08 ,  C07D215/10 ,  C07D215/12 ,  C07F5/022 ,  C07F5/027 ,  C07C215/08 ,  C07C215/10 ,  C07C215/12

摘要： A method of reducing color in an alkanolamine is described. The method includes contacting the alkanolamine with a color-reducing amount of a borane complex effective to provide a color-reduced alkanolamine composition having a Platinum-Cobalt Color Value, according to Test Method ASTM D1209, of less than 50.

公开(公告)号：US10010809B2

公开(公告)日：2018-07-03

申请号：US14768947

申请日：2014-02-19

申请人： MPR Services, Inc.

发明人： David Thomas Hagerman ,  Irwin John Seward, Jr.

IPC分类号： B01D1/22 ,  B01D3/14 ,  B01D3/10 ,  C07C29/76 ,  C07C213/10 ,  B01D3/34 ,  B01D53/14

CPC分类号： B01D3/148 ,  B01D1/22 ,  B01D1/225 ,  B01D3/10 ,  B01D3/346 ,  B01D53/1425 ,  B01D2252/2023 ,  B01D2252/2025 ,  B01D2252/2026 ,  B01D2252/2028 ,  B01D2252/20478 ,  C07C29/76 ,  C07C213/10

摘要： A method for cleaning a contaminated solvent used to treat a gas stream, for example a contaminated glycol or a contaminated amine stream, by vacuum evaporation using a mechanically-maintained horizontally-orientated thin film evaporator, where the contaminant material is recovered from the thin film in solvent-free form, as either a heavy organic material or as free flowing salts.

公开(公告)号：US10000444B2

公开(公告)日：2018-06-19

申请号：US15548028

申请日：2015-02-03

申请人： Unimatec Co., Ltd.

发明人： Keisuke Kokin

IPC分类号： C07C219/06 ,  C07C213/06 ,  C07C213/10

CPC分类号： C07C219/06 ,  C07C213/06 ,  C07C213/10 ,  C10M147/04 ,  C10M169/04 ,  C10M2213/00 ,  C10M2213/04 ,  C10M2213/06 ,  C10N2230/06

摘要： A fluorine-containing ether monocarboxylic acid aminoalkyl ester represented by the general formula: CnF2n+1O[CF(CF3)CF2O]aCF(CF3)COO(CH2)bNR1R2 (wherein R1 is a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, an aryl group, or an aralkyl group, preferably an alkyl group having 1 to 6 carbon atoms or an aryl group; R2 is an alkyl group having 1 to 12 carbon atoms, an aryl group, or an aralkyl group, preferably an alkyl group having 1 to 6 carbon atoms or an aryl group; n is an integer of 1 to 3; a is an integer of 2 to 20, preferably an integer of 4 to 10; and b is an integer of 1 to 12, preferably an integer of 1 to 3). Such a fluorine-containing ether monocarboxylic acid ester having an amino group at the end of the ester group is produced by reacting a perfluoroether carboxylic acid fluoride compound CnF2n+1O[CF(CF3)CF2O]aCF(CF3)COF and a hydroxyalkyl amine compound HO(CH2)bNR1R2 in the presence of an alkali metal fluoride.

公开(公告)号：US09944853B2

公开(公告)日：2018-04-17

申请号：US14760489

申请日：2014-01-10

申请人： SACHEM, INC.

发明人： Tim Engel ,  Alfred Van Lier

IPC分类号： C09K15/22 ,  C07C209/90 ,  C07C211/62 ,  C07C211/63 ,  C07C213/10 ,  C07C215/40 ,  C07C215/72 ,  C07C215/90 ,  C07C211/64

CPC分类号： C09K15/22 ,  C07C209/90 ,  C07C211/62 ,  C07C211/63 ,  C07C211/64 ,  C07C213/10 ,  C07C215/40 ,  C07C215/72 ,  C07C215/90

摘要： A composition including a quaternary onium hydroxide in a non-aqueous solvent, wherein the quaternary ammonium hydroxide has a concentration in the range from about 5% by weight to about 50% by weight of the composition; and imidazolidine-2,4-dione, wherein the imidazolidine-2,4-dione has a concentration in the range from about 10 to about 5000 parts per million of the composition.

公开(公告)号：US20180029975A1

公开(公告)日：2018-02-01

申请号：US15551142

申请日：2015-10-23

申请人： Shanghai Desano Pharmaceutical Co., Ltd. ,  Yancheng Desano Pharmaceutical Co., Ltd. ,  Jiangsu Puxin Pharmaceutical Co., Ltd.

发明人： Nan ZHAO ,  Fei JIANG

IPC分类号： C07C213/10 ,  C07C213/00 ,  C07B53/00

CPC分类号： C07C213/10 ,  C07B53/00 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/70 ,  C07C2601/02 ,  C07D265/18

摘要： Provided is a synthesis process for a chiral cyclopropyl ethynyl tertiary alcohol compound, where a chiral amino alcohol or a chiral amino diol is reacted in the presence of an alkaline reagent and a salt to obtain an optically active propynyl alcohol compound. In particular, the process includes (1) reacting cyclopropyl acetylene with a chiral inducing agent, a chiral auxiliary reagent and zinc halide in an organic solvent in the presence of an alkaline reagent and a sulfonate or a sulphinate to obtain a first reaction mixture; (2) reacting the resultant first reaction mixture with 5-chloro-2-aminotrifluorobenzophenone to form (S)-2-amino-5-chloro-α-cyclopropyl acetylene-α-trifluoromethylbenzyl alcohol. The process avoids an organic zinc reagent and a Grignard reagent, and has the advantages of safe production, an environmentally friendly route, low production costs, a high resultant product yield, a high chiral ee value and is suitable for industrial production.