公开(公告)号：US20170290340A1

公开(公告)日：2017-10-12

申请号：US15478449

申请日：2017-04-04

Applicant: Dow AgroSciences LLC

Inventor： Kenneth E. Narva ,  Huarong Li ,  Sek Yee Tan ,  Tao Xu ,  Vimbai Chikwana ,  Kuan Yang ,  Marc D. Zack ,  Sarah E. Worden

IPC: A01N63/02 ,  C12N15/82 ,  C07K14/325

CPC classification number: A01N63/02 ,  A01N37/46 ,  C07K14/325 ,  C12N15/8286 ,  Y02A40/162

Abstract: Insecticidal toxins derived from Bacillus thuringiensis, polynucleotides encoding such toxins, use of such toxins to control Coleopteran plant pests, and transgenic plants that produce, and are protected, by these toxins are described.

公开(公告)号：US20170283827A1

公开(公告)日：2017-10-05

申请号：US15478957

申请日：2017-04-04

Applicant: Dow AgroSciences LLC ,  Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

Inventor： Kenneth E. Narva ,  Sarah Worden ,  Meghan Frey ,  Murugesan Rangasamy ,  Premchand Gandra ,  Wendy Lo ,  Elane Fishilevich ,  Rainer Fischer ,  Andreas Vilcinskas ,  Eileen Knorr

IPC: C12N15/82 ,  C07K14/325 ,  C12N15/113 ,  C07K14/435 ,  A01N57/16

CPC classification number: C12N15/8286 ,  A01N57/16 ,  C07K14/325 ,  C07K14/43563 ,  C12N15/113 ,  C12N15/8218 ,  C12N2310/14 ,  Y02A40/162

Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in insect pests, including coleopteran and/or hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of insect pests, and the plant cells and plants obtained thereby.

公开(公告)号：US09657308B2

公开(公告)日：2017-05-23

申请号：US13646431

申请日：2012-10-05

Applicant: Dow AgroSciences LLC

Inventor： Kenneth E. Narva ,  Huarong Li ,  Chaoxian Geng ,  Ignacio Larrinua ,  Monica Britt Olson ,  Navin Elango

IPC: C12N15/82 ,  A01N57/16 ,  C12N15/113 ,  C07K14/325 ,  C07K14/435 ,  A01N63/02 ,  A01N65/44

CPC classification number: C12N15/8286 ,  A01N57/16 ,  A01N63/02 ,  A01N65/44 ,  C07K14/325 ,  C07K14/43563 ,  C12N15/113 ,  C12N15/8218 ,  C12N2310/14 ,  Y02A40/162

Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.

公开(公告)号：US20170022518A1

公开(公告)日：2017-01-26

申请号：US15166623

申请日：2016-05-27

Applicant: Dow AgroSciences LLC ,  Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.

Inventor： Kenneth E. Narva ,  Sarah E. Worden ,  Meghan Frey ,  Murugesan Rangasamy ,  Premchand Gandra ,  Wendy Lo ,  Elane Fishilevich ,  Andreas Vilcinskas ,  Eileen Knorr

IPC: C12N15/82 ,  C12Q1/68 ,  A01N57/16 ,  C12N15/113 ,  C07K14/325

CPC classification number: C12N15/8286 ,  A01N57/16 ,  C07K14/325 ,  C07K14/43563 ,  C12N15/113 ,  C12N15/8218 ,  C12N2310/14 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/158 ,  C12Q2600/178 ,  Y02A40/162

Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in insect pests, including coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of insect pests, and the plant cells and plants obtained thereby.

Abstract translation: 本公开涉及核酸分子及其通过RNA干扰介导的昆虫害虫（包括鞘翅目害虫）靶编码和转录非编码序列的抑制来控制害虫的方法。 本公开还涉及用于制备表达可用于控制害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。

公开(公告)号：US09447153B1

公开(公告)日：2016-09-20

申请号：US13621582

申请日：2012-09-17

Applicant: Dow AgroSciences LLC

Inventor： Timothy D. Hey ,  Ignacio M. Larrinua ,  Kenneth E. Narva

IPC: C07K14/325

CPC classification number: C07K14/325 ,  A01N37/46 ,  A01N63/02 ,  C07K2319/50 ,  C12N15/8286 ,  Y02A40/162

Abstract: The present invention includes domain I modifications that improve various attributes of various Coleopteran-active Cry proteins. These attributes can include improved target pest spectrum, potency, and insect resistance management. The subject modifications can affect protoxin activation and the efficiency of pore formation, which can lead to enhanced insect intoxication.

Abstract translation: 本发明包括改进各种鞘翅目活性Cry蛋白的各种属性的I区修饰。 这些属性可以包括改进的目标害虫谱，效力和昆虫抗性管理。 受试者的修饰可以影响原毒素的活化和孔形成的效率，这可以导致昆虫中毒的增强。

公开(公告)号：US20160222407A1

公开(公告)日：2016-08-04

申请号：US14971366

申请日：2015-12-16

Applicant: Dow AgroSciences LLC ,  The Board of Regents of the University of Nebraska

Inventor： Blair D. Siegfried ,  Kenneth E. Narva ,  Kanika Arora ,  Sarah E. Worden ,  Chitvan Khajuria ,  Elane Fishilevich ,  Nicholas P. Storer ,  Meghan Frey ,  Ronda L. Hamm ,  Ana M. Velez

IPC: C12N15/82 ,  A01N57/16 ,  C12N15/113

CPC classification number: C12N15/8286 ,  A01N57/16 ,  C12N15/113 ,  C12N15/8218 ,  C12N2310/14 ,  Y02A40/162

Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.

Abstract translation: 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。

公开(公告)号：US20150176025A1

公开(公告)日：2015-06-25

申请号：US14577811

申请日：2014-12-19

Applicant: Dow AgroSciences LLC ,  Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung E.V.

Inventor： Kenneth E. Narva ,  Huarong Li ,  Chaoxian Geng ,  Kanika Arora ,  Balaji Veeramani ,  Premchand Gandra ,  Sarah Worden ,  Andreas Vilcinskas ,  Eileen Knorr ,  Elane Fishilevich ,  Murugesan Rangasamy ,  Meghan Frey

IPC: C12N15/82 ,  C12N15/113 ,  A01N57/16

CPC classification number: C12N15/8286 ,  C12N15/113 ,  C12N15/8218 ,  C12N2310/14 ,  C12N2310/531 ,  Y02A40/162

Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran and/or hemipteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran and/or hemipteran pests. The disclosure also concerns methods for making that express nucleic acid molecules useful for the control of coleopteran and/or hemipteran pests, and the plant cells and plants obtained thereby.

Abstract translation: 本公开涉及核酸分子及其使用方法，其通过RNA干扰介导的鞘氨酸和/或半翅目害虫中靶编码和转录的非编码序列的抑制来控制鞘翅目和/或半翅目害虫。 本公开还涉及制备表达的核酸分子可用于控制鞘翅目和/或半翅目害虫的方法，以及由此获得的植物细胞和植物。

公开(公告)号：US20130091601A1

公开(公告)日：2013-04-11

申请号：US13646485

申请日：2012-10-05

Applicant: DOW AGROSCIENCES LLC

Inventor： Kenneth E. Narva ,  Huarong Li ,  Chaoxian Geng ,  Ignacio Larrinua ,  Monica Britt Olson ,  Navin Elango

IPC: C12N15/113 ,  C12N15/82 ,  C12N15/32 ,  C12N1/00 ,  C12Q1/68 ,  A01H5/00 ,  A01H5/10 ,  A01N57/16 ,  A01P7/04 ,  A01N65/00 ,  C12N15/12 ,  C12N5/10

CPC classification number: A01N63/02 ,  C07K14/43504 ,  C12N15/113 ,  C12N15/8218 ,  C12N15/8286 ,  C12N2310/14 ,  C12N2320/11 ,  Y02A40/162

Abstract: This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby.

Abstract translation: 本公开涉及核酸分子及其通过RNA干扰介导的鞘内鳞翅目害虫中靶编码和转录非编码序列的抑制来控制鞘翅目害虫的方法。 本公开还涉及用于制备表达可用于控制鞘翅目害虫的核酸分子的转基因植物以及由此获得的植物细胞和植物的方法。