公开(公告)号：US4753964A

公开(公告)日：1988-06-28

申请号：US7109

申请日：1987-01-27

Applicant: David F. Horrobin

Inventor： David F. Horrobin

IPC: A61K33/18 ,  A61K31/19 ,  A61K31/195 ,  A61K31/20 ,  A61K31/22 ,  A61K31/60 ,  A61K33/00 ,  A61K33/14 ,  A61P25/28

CPC classification number: A61K31/20 ,  A61K31/19 ,  A61K33/00

Abstract: This invention relates to the treatment of presenile or sensile dementia and in particular to the treatment of Alzheimer's disease. It is proposed that such conditions may be combatted or their effects alleviated by the administration of a physiologically acceptable lithium compound and/or of an essential fatty acid or a physiologically acceptable salt thereof and there are described herein methods of treatment of such conditions.

Abstract translation: 本发明涉及老年痴呆或感觉性痴呆的治疗，特别涉及阿尔茨海默病的治疗。 提出这样的条件可以通过施用生理上可接受的锂化合物和/或必需脂肪酸或其生理学上可接受的盐来缓解或减轻其效果，并且在此描述了治疗这些病症的方法。

公开(公告)号：US4681896A

公开(公告)日：1987-07-21

申请号：US575744

申请日：1984-01-31

Applicant: David F. Horrobin

Inventor： David F. Horrobin

IPC: A61K31/19 ,  A23D9/00 ,  A23L1/30 ,  A23L1/325 ,  A23L1/48 ,  A61K31/16 ,  A61K31/20 ,  A61K31/22 ,  A61K31/23 ,  A61K31/557 ,  A61K35/56 ,  A61K35/60 ,  A61K36/00 ,  A61K36/185 ,  A61K38/00 ,  A61P3/08 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/30 ,  A61P27/16 ,  A61P35/00 ,  A61P37/08

CPC classification number: A61K35/60 ,  A23D9/00 ,  A61K31/20 ,  A61K31/23 ,  A61K31/557 ,  A61K36/185 ,  Y10S514/861 ,  Y10S514/866

Abstract: A method of treatment of atopic disorders, including eczema, asthma, allergies (especially allergic rhinitis), migraine and disorders associated with atopy including Crohn's disease, ulcerative colitis, otitis media, nephrotic syndrome, or benign breast disease, or breast or other cancer, or diabetes, or alcoholism, with effective amounts of one or more of the metabolites of linoleic acid (GLA, DGLA, AA, 22:4n-6 or 22:5n-6) and one or more of the metabolites of .alpha.-linolenic acid (18:4n-3, 20:4n-3, 20:5n-3, 22:5n-3 or 22:6n-3) are administered as such or in the form of an ester, salt, amide or other derivative convertible in the body thereto alone or in an acceptable pharmaceutical carrier or diluent.

Abstract translation: 治疗特应性疾病的方法，包括湿疹，哮喘，过敏（特别是过敏性鼻炎），偏头痛和与特应性相关的疾病，包括克罗恩病，溃疡性结肠炎，中耳炎，肾病综合征或良性乳腺疾病或乳腺癌或其他癌症， 或糖尿病或酒精中毒，有效量的一种或多种亚油酸（GLA，DGLA，AA，22：4n-6或22：5n-6）的代谢物和一种或多种α-亚麻酸的代谢物 （18：4n-3,20：4n-3,20：5n-3,22：5n-3或22：6n-3）以这样的形式或以酯，盐，酰胺或其他可转换衍生物 在体内单独或在可接受的药物载体或稀释剂中。

公开(公告)号：US4535093A

公开(公告)日：1985-08-13

申请号：US476708

申请日：1983-03-18

Applicant: David F. Horrobin

Inventor： David F. Horrobin

IPC: A23L1/302 ,  A23L1/30 ,  A61K31/13 ,  A61K31/165 ,  A61K31/195 ,  A61K31/20 ,  A61K31/202 ,  A61K31/215 ,  A61K31/23 ,  A61K31/375 ,  A61K31/43 ,  A61K31/485 ,  A61K33/30 ,  A61K45/06 ,  A61P1/00 ,  A61P29/00 ,  A61P37/00 ,  A61P39/02 ,  A61P43/00 ,  A01N37/02 ,  A01N37/00

CPC classification number: A61K31/43 ,  A61K31/20 ,  A61K31/23 ,  A61K31/375 ,  A61K31/485 ,  A61K33/30 ,  A61K45/06 ,  Y10S514/811 ,  Y10S514/889

Abstract: Composition and use of .gamma.-linolenic acid and related materials with ascorbic acid, or ethyl alcohol, or an opiate antagonist such as naloxone, nalorphine or levallorphan, for treating alcoholism or moderating the effects of taking alcohol.

公开(公告)号：US4415554A

公开(公告)日：1983-11-15

申请号：US272083

申请日：1981-06-10

Applicant: David F. Horrobin

Inventor： David F. Horrobin

IPC: A61K31/43 ,  A61K31/545 ,  A61K33/30 ,  A61K31/20 ,  A61K31/23 ,  A61K31/54

CPC classification number: A61K31/545 ,  A61K31/43 ,  A61K33/30 ,  Y10S514/825 ,  Y10S514/899 ,  Y10S514/909

Abstract: Use of .gamma.-linolenic acid and related materials alone or with zinc or .beta.-lactam antibiotics to treat menstrual disorders.

Abstract translation: 单独或与锌或β-内酰胺抗生素一起使用γ-亚麻酸和相关物质治疗月经失调。

公开(公告)号：US4393049A

公开(公告)日：1983-07-12

申请号：US272082

申请日：1981-06-10

Applicant: David F. Horrobin

Inventor： David F. Horrobin

IPC: A61K31/43 ,  A61K31/545 ,  A61K33/30 ,  A61K31/20 ,  A61K31/315 ,  A61K31/33

CPC classification number: A61K31/545 ,  A61K31/43 ,  A61K33/30 ,  Y10S514/825 ,  Y10S514/899 ,  Y10S514/909

Abstract: Use of .gamma.-linolenic acid and related materials alone or with zinc or .beta.-lactam antibiotics to treat obesity.

Abstract translation: 单独或与锌或β-内酰胺抗生素一起使用γ-亚麻酸和相关物质治疗肥胖。

公开(公告)号：US4388324A

公开(公告)日：1983-06-14

申请号：US150402

申请日：1980-05-15

Applicant: David F. Horrobin

Inventor： David F. Horrobin

IPC: A23L1/302 ,  A23L1/30 ,  A61K31/13 ,  A61K31/165 ,  A61K31/195 ,  A61K31/20 ,  A61K31/202 ,  A61K31/215 ,  A61K31/23 ,  A61K31/375 ,  A61K31/43 ,  A61K31/485 ,  A61K33/30 ,  A61K45/06 ,  A61P1/00 ,  A61P29/00 ,  A61P37/00 ,  A61P39/02 ,  A61P43/00 ,  A01N37/02 ,  A01N37/00

CPC classification number: A61K31/43 ,  A61K31/20 ,  A61K31/23 ,  A61K31/375 ,  A61K31/485 ,  A61K33/30 ,  A61K45/06 ,  Y10S514/811 ,  Y10S514/889

Abstract: Composition and use of .gamma.-linolenic acid and related materials with ascorbic acid, or ethyl alcohol, or an opiate antagonist such as naloxone, nalorphine or levallorphan, for treating alcoholism or moderating the effects of taking alcohol.

Abstract translation: 用抗坏血酸或乙醇或鸦片拮抗剂如纳洛酮，纳洛芬或左旋啡喃组成和使用γ-亚麻酸及其相关物质，用于治疗酒精中毒或缓和服用酒精的作用。

公开(公告)号：US4386072A

公开(公告)日：1983-05-31

申请号：US345214

申请日：1982-02-03

Applicant: David F. Horrobin ,  Julian Lieb

Inventor： David F. Horrobin ,  Julian Lieb

IPC: A61K31/20 ,  A61K33/00 ,  A61K33/12

CPC classification number: A61K33/00 ,  A61K31/20

Abstract: A method for the treatment or prophylaxis of disorders of inflammation and immunity and disorders associated with smooth muscle spasm, by administering dihomo-.gamma.-linolenic acid or a bioprecursor thereof conjointly with a physiologically acceptable lithium salt. Vitamin E and related tocopherols may optionally be also administered.

Abstract translation: 通过与生理上可接受的锂盐联合给予二 - γ-亚麻酸或其生物前体，治疗或预防与平滑肌痉挛相关的炎症和免疫疾病和紊乱的方法。 还可以任选地施用维生素E和相关的生育酚。

公开(公告)号：US5922345A

公开(公告)日：1999-07-13

申请号：US584426

申请日：1996-01-11

Applicant: David F. Horrobin ,  Lars Lindmark

Inventor： David F. Horrobin ,  Lars Lindmark

IPC: A23L1/29 ,  A23L1/30 ,  A61K31/202 ,  A61K31/23

CPC classification number: A61K31/202 ,  A23L33/12 ,  A23L33/40

Abstract: Countering side effects of parenteral or fluid-diet enteral nutrition by adding one or more 6-desaturated essential fatty acids (EFAs) to parenteral or enteral composition (particularly low-fat compositions) being given, or giving them in addition to the compositions.

Abstract translation: 通过向给予的肠胃外或肠内组合物（特别是低脂肪组合物）中加入一种或多种6-去饱和必需脂肪酸（EFAs）或给予它们以补充组合物来抵抗肠胃外或流体饮食肠内营养的副作用。

公开(公告)号：US5859055A

公开(公告)日：1999-01-12

申请号：US557545

申请日：1995-11-14

Applicant: David F. Horrobin ,  John C. M. Stewart

Inventor： David F. Horrobin ,  John C. M. Stewart

IPC: A61K31/20 ,  A61K31/202 ,  A61P9/00 ,  A61P9/10 ,  C07C57/03 ,  C07C57/12 ,  A61K31/22

CPC classification number: A61K31/20 ,  Y10S514/824

Abstract: Gamma-linolenic acid and/or dihomo-gamma-linolenic acid is used in the preparation of a medicament for inhibiting reocclusion of an artery from which an occlusion or other blockage has been removed, or for preventing occlusion of peripheral or coronary arteries. The medicament may also comprise eicosapentaenoic acid.

Abstract translation: γ-亚麻酸和/或二 - γ-亚麻酸用于制备用于抑制已经从其中除去闭塞或其它阻塞的动脉再闭塞或用于防止外周或冠状动脉闭塞的药物中的用途。 药物还可以包含二十碳五烯酸。

公开(公告)号：US5663202A

公开(公告)日：1997-09-02

申请号：US690545

申请日：1996-07-31

Applicant: David F. Horrobin ,  Catherine A. Scott

Inventor： David F. Horrobin ,  Catherine A. Scott

IPC: A61K31/20 ,  A61K31/202 ,  A61P25/00 ,  A61P43/00

CPC classification number: A61K31/202 ,  A61K31/20

Abstract: Damage to the gastrointestinal tract as a consequence of exposure to ionising radiation is prevented or treated by administration of GLA and/or DGLA. Medicaments containing GLA and/or DGLA for such treatment or prevention may also further comprise EPA and/or DHA.

Abstract translation: 由于暴露于电离辐射而导致的胃肠道损伤通过施用GLA和/或DGLA来预防或治疗。 含有GLA和/或DGLA用于治疗或预防的药物还可以进一步包含EPA和/或DHA。