公开(公告)号：US20080096914A1

公开(公告)日：2008-04-24

申请号：US11883596

申请日：2006-02-08

Applicant: Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

Inventor： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

IPC: A61K31/4743 ,  C07D498/02

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。

公开(公告)号：US20070244112A1

公开(公告)日：2007-10-18

申请号：US11597142

申请日：2005-05-25

Applicant: Klaus Pekari ,  Thomas Baer ,  Bjorn Bartels ,  Mathias Schmidt ,  Thomas Beckers

Inventor： Klaus Pekari ,  Thomas Baer ,  Bjorn Bartels ,  Mathias Schmidt ,  Thomas Beckers

IPC: A61K31/44 ,  A61K31/497 ,  A61K31/535 ,  A61P35/00 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D495/04

Abstract: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.

Abstract translation: 其中Ra和Rb具有说明书中所示含义的某种式（I）的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。

公开(公告)号：US5942602A

公开(公告)日：1999-08-24

申请号：US800198

申请日：1997-02-13

Applicant: Winfried S. Wels ,  Mathias Schmidt ,  Evangelia Vakalopoulou ,  Douglas W Schneider

Inventor： Winfried S. Wels ,  Mathias Schmidt ,  Evangelia Vakalopoulou ,  Douglas W Schneider

IPC: A61K38/00 ,  A61K47/48 ,  C07K16/28 ,  C12N15/13 ,  C07K16/30

CPC classification number: C07K16/2863 ,  A61K47/48561 ,  A61K2039/505 ,  A61K38/00 ,  C07K2317/622 ,  C07K2319/00

Abstract: The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating and diagnosing the status of pathological conditions such as cancer and cellular hyper proliferation.

Abstract translation: 本发明涉及EGF受体的单链和双链抗体。 本发明还涉及这种抗体的毒素缀合物。 这些抗体可用于治疗和诊断病理状况如癌症和细胞超增殖的状况。