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公开(公告)号：US6129915A
公开(公告)日：2000-10-10
申请号：US296595
申请日：1999-04-23
IPC分类号： A61K38/00 , A61K47/48 , C07K16/28 , C12N15/13 , A61K39/395
CPC分类号： C07K16/2863 , A61K47/48561 , A61K2039/505 , A61K38/00 , C07K2317/622 , C07K2319/00
摘要： The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating and diagnosing the status of pathological conditions such as cancer and cellular hyper proliferation.
摘要翻译： 本发明涉及EGF受体的单链和双链抗体。 本发明还涉及这种抗体的毒素缀合物。 这些抗体可用于治疗和诊断病理状况如癌症和细胞超增殖的状况。
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公开(公告)号：US07893217B2
公开(公告)日：2011-02-22
申请号：US11981132
申请日：2007-10-30
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
摘要翻译： 本发明涉及新的人细胞外基质多肽，称为RG1，编码多肽的多核苷酸，用于产生多肽的方法，表达载体和用于表达多肽的遗传工程改造的宿主细胞。 本发明还涉及针对多肽的抗体以及在研究，诊断和治疗应用中使用多核苷酸，多肽和抗体的方法。
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公开(公告)号：US20090214422A1
公开(公告)日：2009-08-27
申请号：US11981240
申请日：2007-10-30
IPC分类号： A61K51/10 , A61K39/395 , A61P35/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
摘要翻译： 本发明涉及新的人细胞外基质多肽，称为RG1，编码多肽的多核苷酸，用于产生多肽的方法，表达载体和用于表达多肽的遗传工程改造的宿主细胞。 本发明还涉及针对多肽的抗体以及在研究，诊断和治疗应用中使用多核苷酸，多肽和抗体的方法。
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公开(公告)号：US06682902B2
公开(公告)日：2004-01-27
申请号：US09732357
申请日：2000-12-07
IPC分类号： G01N3353
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to methods for utilizing the polynucleotides and polypeptides in research, diagnosis, and therapeutic applications.
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公开(公告)号：US20120142593A1
公开(公告)日：2012-06-07
申请号：US13260564
申请日：2010-03-24
申请人： Xiao-Yan Zhao , Peter John Kretschmer , Thomas Eugene Thompson , Douglas W. Schneider , John Edward Murphy
发明人： Xiao-Yan Zhao , Peter John Kretschmer , Thomas Eugene Thompson , Douglas W. Schneider , John Edward Murphy
IPC分类号： A61K38/37 , C12N15/62 , C12N15/63 , C12N5/10 , A61P7/04 , C12N1/15 , C12N1/19 , C12N1/13 , C12P21/00 , C07K19/00 , C12N1/21
CPC分类号： C07K14/755 , A61K38/00 , C07K2319/30
摘要： A Factor VIII fusion protein or a Factor VIII fusion heterodimer comprising Factor VIII in which an amino acid sequence of a modulator is present in the B-domain, or an amino acid sequence of a modulator replaces some or all of the amino acid sequence of the B-domain is disclosed. Nucleic acids encoding the inventive fusion proteins and fusion heterodimers are also disclosed, as are methods for producing the fusion proteins and fusion heterodimers, pharmaceutical compositions, and methods of treating deficiencies in coagulation with the inventive fusion molecules.
摘要翻译： 包含因子VIII的因子VIII融合蛋白或因子VIII融合异二聚体，其中调节剂的氨基酸序列存在于B结构域中，或调节剂的氨基酸序列取代了部分或全部氨基酸序列 B域被公开。 还公开了编码本发明的融合蛋白和融合异源二聚体的核酸，以及产生融合蛋白和融合异源二聚体的方法，药物组合物以及用本发明的融合分子治疗凝血缺陷的方法。
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6.发明授权Methods for treating disease-states associated with RG1 using immunoconjugates 失效使用免疫缀合物治疗与RG1相关的疾病状态的方法公开(公告)号：US07887804B2
公开(公告)日：2011-02-15
申请号：US11981240
申请日：2007-10-30
IPC分类号： A61K39/395 , C12P21/04 , C12P21/08 , C07H21/04 , C07H16/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
摘要翻译： 本发明涉及新的人细胞外基质多肽，称为RG1，编码多肽的多核苷酸，用于产生多肽的方法，表达载体和用于表达多肽的遗传工程改造的宿主细胞。 本发明还涉及针对多肽的抗体以及在研究，诊断和治疗应用中使用多核苷酸，多肽和抗体的方法。
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公开(公告)号：US20090292112A1
公开(公告)日：2009-11-26
申请号：US11981132
申请日：2007-10-30
IPC分类号： C07K16/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
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公开(公告)号：US5942602A
公开(公告)日：1999-08-24
申请号：US800198
申请日：1997-02-13
CPC分类号： C07K16/2863 , A61K47/48561 , A61K2039/505 , A61K38/00 , C07K2317/622 , C07K2319/00
摘要： The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating and diagnosing the status of pathological conditions such as cancer and cellular hyper proliferation.
摘要翻译： 本发明涉及EGF受体的单链和双链抗体。 本发明还涉及这种抗体的毒素缀合物。 这些抗体可用于治疗和诊断病理状况如癌症和细胞超增殖的状况。
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