公开(公告)号：US20230076417A1

公开(公告)日：2023-03-09

申请号：US17714735

申请日：2022-04-06

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Joost MELIS ,  Tom VINK ,  Hendrik TEN NAPEL ,  Esther BREIJ ,  David SATIJN ,  Paul PARREN

IPC: C07K16/32 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28

Abstract: The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10−9 and 10−8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.

公开(公告)号：US20220177585A1

公开(公告)日：2022-06-09

申请号：US17349482

申请日：2021-06-16

Applicant: GENMAB A/S

Inventor： Catharina Emanuele GERARDA HAVENITH ,  Tom VINK ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: C07K16/28 ,  G01N33/566

Abstract: The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.

公开(公告)号：US20220169738A1

公开(公告)日：2022-06-02

申请号：US17369542

申请日：2021-07-07

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Simone DE HAIJ ,  Thilo RIEDL ,  Rene HOET ,  Ole BAADSGAARD ,  Jan VAN DE WINKEL ,  David SATIJN ,  Paul PARREN ,  Aran Frank LABRIJN ,  Joyce MEESTERS ,  Janine SCHUURMAN ,  Edward N. VAN DEN BRINK

IPC: C07K16/28 ,  C07K16/32

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20210122830A1

公开(公告)日：2021-04-29

申请号：US17003442

申请日：2020-08-26

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Edward N. VAN DEN BRINK ,  Simone DE HAIJ ,  Thilo RIEDL ,  Rene HOET ,  Ole BAADSGAARD, D.M.Sc. ,  David SATIJN ,  Jan VAN DE WINKEL ,  Paul PARREN

IPC: C07K16/30 ,  C07K16/32

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20210107985A1

公开(公告)日：2021-04-15

申请号：US16883333

申请日：2020-05-26

Applicant: GENMAB A/S

Inventor： Janine SCHUURMAN ,  Catharina Emanuele Gerarda HAVENITH ,  Paul PARREN ,  Jan G. J. VAN DE WINKEL ,  Denise Leah WILLIAMS ,  Jørgen PETERSEN ,  Ole BAADSGAARD

IPC: C07K16/28 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  A61N5/06 ,  C07K16/42 ,  C07K16/46 ,  G01N33/574 ,  G01N33/569

Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US20180298106A1

公开(公告)日：2018-10-18

申请号：US15909540

申请日：2018-03-01

Applicant: GENMAB A/S

Inventor： Michel DE WEERS ,  Tim WALSETH ,  Jan VAN DE WINKEL ,  Tom VINK ,  Paul PARREN

IPC: C07K16/28 ,  G01N33/573 ,  A61K45/06 ,  A61K39/395

Abstract: Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies.

公开(公告)号：US20180201693A1

公开(公告)日：2018-07-19

申请号：US15742803

申请日：2016-07-01

Applicant: GENMAB A/S

Inventor： Richard G. HIBBERT ,  Aran F. LABRIJN ,  Arnout F. GERRITSEN ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/46

CPC classification number: C07K16/468 ,  C07K16/2863 ,  C07K16/2887 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2317/94

Abstract: Bispecific and multispecific antibodies having differentially modified light chains, that allows for isolation of the bispecific or multispecific antibodies based on a differential affinity towards an affinity reagent.

公开(公告)号：US20170369594A1

公开(公告)日：2017-12-28

申请号：US15599395

申请日：2017-05-18

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Bart DE GOEIJ ,  Aran Frank LABRIJN ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/46 ,  A61K39/395 ,  C07K1/113 ,  C07K16/10 ,  C07K16/28 ,  A61K47/68 ,  C07K16/32 ,  A61K39/00

Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.

公开(公告)号：US20170327597A1

公开(公告)日：2017-11-16

申请号：US15536143

申请日：2015-12-18

Applicant: GENMAB A/S

Inventor： Aran F. LABRIJN ,  Joyce I. MEESTERS ,  Janine SCHUURMAN ,  Paul PARREN ,  Anthony ARMSTRONG ,  Matthew BUNCE ,  Mark CHIU ,  Thomas NESSPOR ,  Adam ZWOLAK

IPC: C07K16/46 ,  C07K16/40 ,  A61K49/00 ,  C07K16/28

CPC classification number: C07K16/462 ,  A61K49/0008 ,  C07K16/00 ,  C07K16/2809 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/64 ,  C07K2317/73

Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.

公开(公告)号：US20170240640A1

公开(公告)日：2017-08-24

申请号：US15420824

申请日：2017-01-31

Applicant: GENMAB A/S

Inventor： Janine SCHUURMAN ,  Catharina Emanuele Gerarda HAVENITH ,  Paul PARREN ,  Jan G. J. VAN DE WINKEL ,  Denise Leah WILLIAMS ,  Jørgen PETERSEN ,  Ole BAADSGAARD

IPC: C07K16/28 ,  G01N33/569 ,  C07K16/42 ,  G01N33/68 ,  A61K45/06 ,  A61K39/395

Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.