公开(公告)号：US08918176B2

公开(公告)日：2014-12-23

申请号：US13777091

申请日：2013-02-26

Applicant: Medtronic, Inc.

Inventor： Dwight E. Nelson ,  Jonathon E. Giftakis

IPC: A61N1/36 ,  A61B5/00

CPC classification number: A61N1/36139 ,  A61B5/4052 ,  A61B5/4088 ,  A61B5/4094 ,  A61B5/4842 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082

Abstract: Various embodiments concern assessing a degenerative cognitive disorder of a patient based on a plurality of episodes of non-motor epileptiform bioelectrical activity. The non-motor epileptiform bioelectrical activity can be detected from one or more bioelectrical brain signals. A worsening cognitive disorder may be indicated by an increase in one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. A therapy can be delivered to reduce one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. The delivery of the therapy can be controlled based on the plurality of episodes of non-motor epileptiform bioelectrical activity.

Abstract translation: 各种实施方案涉及基于多次发作的非运动性癫痫样生物电活性来评估患者的退行性认知障碍。 可以从一个或多个生物电脑信号检测非运动性癫痫样生物电活动。 恶化的认知障碍可以通过非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种的增加来表示。 可以递送治疗以减少非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种。 可以基于多次非运动性癫痫样生物电活动来控制治疗的递送。

公开(公告)号：US08918175B2

公开(公告)日：2014-12-23

申请号：US13778348

申请日：2013-02-27

Applicant: Medtronic, Inc.

Inventor： Dwight E. Nelson ,  Xin Su ,  Thaddeus S. Brink ,  Blake A. Hedstrom

IPC: A61N1/05 ,  A61N1/08 ,  A61N1/36 ,  A61B5/021 ,  A61B5/00 ,  A61B5/024

CPC classification number: A61N1/36132 ,  A61B5/021 ,  A61B5/024 ,  A61B5/4255 ,  A61B5/4368 ,  A61B5/4393 ,  A61N1/08 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36107 ,  A61N1/3615 ,  A61N1/36171 ,  A61N1/37247

Abstract: Electrical stimulation therapy may be delivered to a patient to selectively and independently address different conditions of a pelvic floor disorder of the patient. The conditions of a pelvic floor disorder may include, for example, a lower urinary tract dysfunction (e.g., urinary or fecal incontinence) and sexual dysfunction (e.g., an impaired sexual reflex response to a sexual stimulus). In some examples, a system is configured to selectively deliver a first electrical stimulation therapy that is configured to elicit an inhibitory physiological response from the patient related to voiding, a second electrical stimulation therapy that is configured to improve a sexual reflex response of the patient to a sexual stimulus, and a third electrical stimulation therapy that is configured to both elicit the inhibitory physiological response from the patient related to voiding and increase a sexual response of the patient to a sexual stimulus.

Abstract translation: 电刺激治疗可以递送给患者以选择性且独立地解决患者盆底疾病的不同情况。 盆底疾病的状况可能包括例如下尿路功能障碍（例如尿或大便失禁）和性功能障碍（例如，对性刺激的性反射受损）。 在一些示例中，系统被配置为选择性地递送第一电刺激疗法，其被配置为引起患者与排尿相关的抑制性生理反应，第二电刺激治疗被配置为改善患者的性反射反应 性刺激和第三种电刺激疗法，其被配置为既引起来自患者的与排尿相关的抑制性生理反应并且增加患者对性刺激的性反应。

公开(公告)号：US20140277250A1

公开(公告)日：2014-09-18

申请号：US14210981

申请日：2014-03-14

Applicant: Medtronic, Inc.

Inventor： Xin Su ,  Dwight E. Nelson ,  Timothy J. Ness

IPC: A61N1/36

CPC classification number: A61N1/36007 ,  A61N1/36135 ,  A61N1/36167

Abstract: In some examples, relatively low frequency (e.g., less than about 50 Hertz) electrical stimulation therapy is delivered to a target tissue site proximate to one or more of the T9, T10, T11, T12, L1, L2, or L3 (“T9-L3”) spinal nerves of a patient to manage a pelvic floor disorder, such as urinary retention, fecal retention, or both. The relatively low frequency electrical stimulation therapy is configured to excite the one or more of the T9-L3 spinal nerves, which may generate an activating response from the patient related to voiding and help promote voiding by the patient. For example, the low frequency electrical stimulation may be configured to help improve the patient's pelvic sensations, which may help the patient better control urination.

Abstract translation: 在一些示例中，相对低频率（例如，小于约50赫兹）的电刺激治疗被递送到靠近T9，T10，T11，T12，L1，L2或L3中的一个或多个的靶组织位点（“T9 -L3“）脊髓神经来治疗盆底疾病，例如尿潴留，粪便保留或两者。 相对低频的电刺激治疗被配置为激发一个或多个T9-L3脊神经，其可以产生患者与排尿相关的激活反应并且有助于促进患者的排尿。 例如，低频电刺激可以被配置为帮助改善患者的盆腔感觉，这可以帮助患者更好地控制排尿。