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公开(公告)号：US12036410B2
公开(公告)日：2024-07-16
申请号：US17062213
申请日：2020-10-02
Applicant: Medtronic, Inc.
Inventor： David E. Linde , Benjamin P. Isaacson , Nicholas D. Buse , Duane L. Bourget , Robert S. Raike , Jonathon E. Giftakis , Caleb C. Zarns , Thomas L. Chouinard
CPC classification number: A61N1/36139 , A61N1/0534 , A61N1/36067 , A61N1/36171 , A61N1/36175 , A61N1/36192 , A61N1/36071
Abstract: A medical device or system of medical devices can be configured to detect an indicator of a symptom in a patient; in response to detecting the indicator of the symptom in the patient, deliver to the patient a first stimulation therapy; and in response to determining that the indicator of the symptom has been present for more than a threshold amount of time after beginning to deliver the first stimulation therapy a second stimulation therapy different than the first stimulation therapy.
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公开(公告)号：US12036401B2
公开(公告)日：2024-07-16
申请号：US16773719
申请日：2020-01-27
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Nathan A. Torgerson
CPC classification number: A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
Abstract: A medical system implements a seizure detection algorithm to detect a seizure based on a first patient parameter. The medical system monitors a second patient parameter to adjust the seizure detection algorithm. In some examples, the medical system determines whether a seizure for which therapy delivery is desirable occurred based on a second patient parameter. If a target seizure occurred, and the seizure detection algorithm did not detect the target seizure, the medical system adjusts the seizure detection algorithm to detect the target seizure. For example, the medical system may determine a first patient parameter characteristic indicative of the target seizure detected based on the second patient parameter and store the first patient parameter characteristic as part of the seizure detection algorithm. In some examples, the first patient parameter is an electrical brain signal and the second patient parameter is patient activity (e.g., patient motion or posture).
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公开(公告)号：US20220266040A1
公开(公告)日：2022-08-25
申请号：US17645669
申请日：2021-12-22
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Scott R. Stanslaski , William C. Harding , Ryan Gertenbach , Brian L. Bechard , Nathan A. Torgerson
Abstract: Processing circuitry of a medical device configured to determine that a condition occurred. The condition may be associated with at least one of a patient or an implantable medical device. Responsive to determining that the condition occurred, access instructions stored at a memory for selecting an alert mode from a plurality of alert modes, then select the alert mode based on the condition. Responsive to selecting the alert mode, output, in the selected alert mode, a notification that indicates the condition occurred.
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公开(公告)号：US09724517B2
公开(公告)日：2017-08-08
申请号：US14194026
申请日：2014-02-28
Applicant: MEDTRONIC, INC.
CPC classification number: A61N1/36146 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36139 , A61N1/3615 , A61N1/36167 , A61N1/372
Abstract: Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
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5.发明申请ASSESSING COGNITIVE DISORDERS BASED ON NON-MOTOR EPILEPTIFORM BIOELECTRICAL BRAIN ACTIVITY 有权基于非电动机电生理大脑活动评估认知障碍公开(公告)号：US20140081347A1
公开(公告)日：2014-03-20
申请号：US13777091
申请日：2013-02-26
Applicant: Medtronic, Inc.
Inventor： Dwight E. Nelson , Jonathon E. Giftakis
IPC: A61N1/36
CPC classification number: A61N1/36139 , A61B5/4052 , A61B5/4088 , A61B5/4094 , A61B5/4842 , A61N1/36025 , A61N1/36064 , A61N1/36082
Abstract: Various embodiments concern assessing a degenerative cognitive disorder of a patient based on a plurality of episodes of non-motor epileptiform bioelectrical activity. The non-motor epileptiform bioelectrical activity can be detected from one or more bioelectrical brain signals. A worsening cognitive disorder may be indicated by an increase in one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. A therapy can be delivered to reduce one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. The delivery of the therapy can be controlled based on the plurality of episodes of non-motor epileptiform bioelectrical activity.
Abstract translation: 各种实施方案涉及基于多次发作的非运动性癫痫样生物电活性来评估患者的退行性认知障碍。 可以从一个或多个生物电脑信号检测非运动性癫痫样生物电活动。 恶化的认知障碍可以通过非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种的增加来表示。 可以递送治疗以减少非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种。 可以基于多次非运动性癫痫样生物电活动来控制治疗的递送。
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Patent Agency Ranking
公开(公告)号：US11925806B2
公开(公告)日：2024-03-12
申请号：US16941085
申请日：2020-07-28
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Paul H. Stypulkowski
CPC classification number: A61N1/36139 , A61N1/0534 , A61N1/36082 , A61N1/36096 , A61N1/36171
Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
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公开(公告)号：US20220266041A1
公开(公告)日：2022-08-25
申请号：US17645682
申请日：2021-12-22
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Scott R. Stanslaski , William C. Harding , Ryan Gertenbach , Brian L. Bechard , Nathan A. Torgerson
Abstract: An implantable medical device that includes a memory, stimulation circuitry configured to deliver electrical stimulation to a patient, and processing circuitry operably coupled to the memory. The processing circuitry is configured to: control the stimulation circuitry to output electrical stimulation therapy to a patient via a first electrode combination and control the stimulation circuitry to output a notification stimulation via a second electrode combination and interleaved with the electrical stimulation therapy. The notification stimulation may include an intensity above a perception level of the patient, and the second electrode combination may include an electrode disposed at an implant site of the implantable medical device.
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公开(公告)号：US20220266039A1
公开(公告)日：2022-08-25
申请号：US17645661
申请日：2021-12-22
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Scott R. Stanslaski , William C. Harding , Ryan Gertenbach , Brian L. Bechard , Nathan A. Torgerson
Abstract: A system that includes a movement sensor configured to be implanted within a patient and generate a movement signal and processing circuitry configured to be implanted within the patient and configured to: receive the movement signal from the movement sensor and determine that the movement signal is representative of a communication from the patient. Responsive to determining that the movement signal is representative of the communication, the processing circuitry may cause an alert associated with the communication to be output to the patient. The processing circuitry may also perform an action requested by the communication.
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公开(公告)号：US11077305B2
公开(公告)日：2021-08-03
申请号：US15699873
申请日：2017-09-08
Applicant: MEDTRONIC, INC.
Inventor： Jonathon E. Giftakis , Timothy J. Denison , Paul H. Stypulkowski , Scott R. Stanslaski , Robert S. Raike , Mae Eng , David E. Linde , Thomas Adamski
Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
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公开(公告)号：US20180326217A1
公开(公告)日：2018-11-15
申请号：US16036439
申请日：2018-07-16
Applicant: Medtronic, Inc.
Inventor： Jonathon E. Giftakis , Paul H. Stypulkowski
CPC classification number: A61N1/36139 , A61N1/0534 , A61N1/36082 , A61N1/36096 , A61N1/36171
Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
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