公开(公告)号：US20050043766A1

公开(公告)日：2005-02-24

申请号：US10896760

申请日：2004-07-22

申请人： Orhan Soykan ,  Donovan Maura

发明人： Orhan Soykan ,  Donovan Maura

IPC分类号： A61L27/38 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61L27/3839 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/368

摘要： In general, the invention is directed to methods for electrically stimulating transplanted biological material, such as transplanted cells, to improve the performance of the heart during systole. In particular, the invention is directed to devices and techniques for stimulating biological material transplanted in a myocardium of a heart during an ejection phase of a cardiac cycle. The transplanted biological material may include cells, such as skeletal myoblasts, precursor cells, endothelial cells, differentiated or undifferentiated stem cells, undifferentiated contractile cells, fibroblasts and genetically engineered cells. In general, stimulation of the transplanted biological material during the ejection phase of the cardiac cycle, when the aortic and pulmonary valves are open, provides hemodynamic assistance to the heart.

摘要翻译： 通常，本发明涉及用于电刺激移植的生物材料（例如移植细胞）的方法，以改善收缩期心脏的表现。 特别地，本发明涉及用于在心动周期的喷射阶段刺激移植在心脏心肌中的生物材料的装置和技术。 移植的生物材料可以包括细胞，例如骨骼成肌细胞，前体细胞，内皮细胞，分化或未分化的干细胞，未分化的收缩细胞，成纤维细胞和遗传工程细胞。 通常，当主动脉和肺动脉瓣开放时，在心动周期的喷射阶段期间移植的生物材料的刺激为心脏提供血液动力学辅助。

公开(公告)号：US06775574B1

公开(公告)日：2004-08-10

申请号：US09654185

申请日：2000-09-01

申请人： Orhan Soykan ,  Maura G. Donovan

发明人： Orhan Soykan ,  Maura G. Donovan

IPC分类号： A61N108

CPC分类号： A61N1/36042 ,  A61N1/326 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/3756 ,  C12N5/0657

摘要： An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near an infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium.

摘要翻译： 提供了一种可植入系统，其包括：包含遗传物质，未分化的收缩细胞或能够在患者心肌的梗塞区域内和/或附近形成新的收缩组织的组合的细胞增殖源; 以及用于电刺激患者心肌梗死区域内和/或附近的新的收缩组织的电刺激装置。