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    Method and device to treat kidney disease
    1.
    发明授权
    Method and device to treat kidney disease 有权
    治疗肾脏疾病的方法和装置

    公开(公告)号：US08641659B2

    公开(公告)日：2014-02-04

    申请号：US13399910

    申请日：2012-02-17

    申请人： Orhan Soykan ,  Carl Schu ,  Kimberly Chaffin

    发明人： Orhan Soykan ,  Carl Schu ,  Kimberly Chaffin

    IPC分类号： A61M1/00

    CPC分类号： A61M1/28 ,  A61M1/1678 ,  A61M1/1696 ,  A61M1/284 ,  A61M2205/04

    摘要： The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.

    摘要翻译： 本发明涉及一种通过在体腔内产生纤维化腔并进行透析或大量流体去除来透析和/或大量流体去除的方法和装置。 描述了具有纤维化室和泵的可植入医疗装置。 可以进一步提供透析室和可选的电渗析装置。 附加的控制器使用感官反馈来通过改变纤维化腔内的细胞外液体保留来调节流体水平。 该装置可用于治疗也可能患有心脏肾综合征和高血压的慢性肾脏疾病患者。

    Electronic and biological pacemaker systems
    4.
    发明授权
    Electronic and biological pacemaker systems 有权
    电子和生物起搏器系统

    公开(公告)号：US07778705B2

    公开(公告)日：2010-08-17

    申请号：US11554770

    申请日：2006-10-31

    申请人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    发明人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    IPC分类号： A61N1/00

    CPC分类号： A61N1/362 ,  A61N1/3627

    摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.

    摘要翻译： 心脏起搏系统包括至少一个电子或生物起搏器作为主要起搏器，以及至少一个电子或生物起搏器作为备用起搏器。 当植入时，主起搏器产生调节心脏功能的主要起搏刺激。 当电子起搏器不能以预定起搏速度调节心脏功能时，备用起搏器提供备用起搏刺激。 心脏起搏系统通过植入在可以为心脏组织提供起搏刺激的区域中实现。

    DIAGNOSTIC KITS AND METHODS FOR SCD OR SCA THERAPY SELECTION
    5.
    发明申请
    DIAGNOSTIC KITS AND METHODS FOR SCD OR SCA THERAPY SELECTION 审中-公开
    诊断套件及SCD或SCA治疗方法选择

    公开(公告)号：US20090131276A1

    公开(公告)日：2009-05-21

    申请号：US12271385

    申请日：2008-11-14

    申请人： Orhan SOYKAN ,  Tara NAHEY ,  Jeffrey LANDE

    发明人： Orhan SOYKAN ,  Tara NAHEY ,  Jeffrey LANDE

    IPC分类号： C40B30/04 ,  C12Q1/68 ,  C40B40/08

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： Variations in certain genomic sequences useful as genetic markers of Sudden Cardiac Death (“SCD”), or Sudden Cardiac Arrest (“SCA”) risk, are described. Novel diagnostic kits and methods employing these genetic markers are used in assessing the risk of SCD, or SCA. Methods of distinguishing patients having an increased susceptibility to SCD, or SCA, through use of these markers, alone or in combination with other markers, are also provided. Further, methods of assessing the need for an Implantable Cardio Defibrillators (“ICD”) in a patient are taught.

    摘要翻译： 描述了用作突发心脏死亡（“SCD”）或突发性心脏骤停（“SCA”）风险的遗传标记的某些基因组序列的变异。 使用这些遗传标记的新型诊断试剂盒和方法用于评估SCD或SCA的风险。 还提供了通过使用这些标记物单独或与其它标记物组合来区分对SCD敏感性增加的患者或SCA的方法。 此外，教导了评估患者中植入性心脏除颤器（“ICD”）的需要的方法。

    Cellular and genetic intervention to treat ventricular tachycardia
    6.
    发明申请
    Cellular and genetic intervention to treat ventricular tachycardia 审中-公开
    细胞和遗传干预治疗室性心动过速

    公开(公告)号：US20060088503A1

    公开(公告)日：2006-04-27

    申请号：US11249948

    申请日：2005-10-13

    申请人： Vinod Sharma ,  Orhan Soykan ,  Maura Donovan ,  Walter Olson

    发明人： Vinod Sharma ,  Orhan Soykan ,  Maura Donovan ,  Walter Olson

    IPC分类号： A01N63/00

    CPC分类号： A61L27/3873 ,  A61K9/0024 ,  A61K38/00 ,  A61K48/005 ,  A61L27/227 ,  A61L27/3834 ,  C07K14/705

    摘要： A method for decreasing risk of ventricular tachycardia following myocardial infarction increases cell-to-cell coupling and/or excitability in the border zone of an infarcted region of myocardial tissue. Enhanced conduction to treat the border zone is carried out by genetically modifying myocytes in the border zone to form more gap junctions and/or sodium channels and/or calcium channels. Alternatively, enhanced conduction is carried out by incorporating cells into the border zone that form gap junctions with the myocytes and/or form sodium channels and/or form calcium channels.

    摘要翻译： 降低心肌梗死后室性心动过速风险的方法增加了心肌组织梗塞区域边界区的细胞间电偶耦合和/或兴奋性。 通过在边界区域中遗传修饰肌细胞以形成更多的间隙连接和/或钠通道和/或钙通道来进行治疗边界区域的增强传导。 或者，通过将细胞并入到与肌细胞形成间隙连接和/或形成钠通道和/或形成钙通道的边界区域中来进行增强的传导。

    Self-improving identification method
    7.
    发明申请
    Self-improving identification method 有权
    自我改进识别方法

    公开(公告)号：US20060013456A1

    公开(公告)日：2006-01-19

    申请号：US11157568

    申请日：2005-06-21

    申请人： Orhan Soykan

    发明人： Orhan Soykan

    IPC分类号： G06K9/00

    CPC分类号： G06F19/24 ,  G06F19/18 ,  G06F19/28

    摘要： A self-improving identification method classifies specimens based on class identifiers. The system stores specimen profiles in a database that is updated with additional specimen profiles and with follow-up data that corrects classification of specimens that were initially incorrectly classified. Algorithms use the updated database to discover new class identifiers, modify thresholds of known class identifiers, and drop unnecessary class identifiers to improve classification of specimens.

    摘要翻译： 自我改进识别方法根据类标识符对标本进行分类。 系统将样本轮廓存储在使用附加样本轮廓更新的数据库中，并具有校正最初错误分类的样本分类的后续数据。 算法使用更新的数据库来发现新的类标识符，修改已知类标识符的阈值，并删除不必要的类标识符以改进样本分类。

    Method and apparatus for accoustically coupling implantable medical device telemetry data to a telephonic connection
    10.
    发明授权
    Method and apparatus for accoustically coupling implantable medical device telemetry data to a telephonic connection 失效
    将植入式医疗设备遥测数据与电话连接进行声学耦合的方法和装置

    公开(公告)号：US06236889B1

    公开(公告)日：2001-05-22

    申请号：US09235444

    申请日：1999-01-22

    申请人： Orhan Soykan ,  William J. Combs ,  Michael B. Shelton

    发明人： Orhan Soykan ,  William J. Combs ,  Michael B. Shelton

    IPC分类号： A61N108

    CPC分类号： A61N1/37217 ,  A61N1/08 ,  A61N1/3727 ,  H04B11/00 ,  H04B13/005 ,  Y10S128/904

    摘要： An apparatus and method for communicating acoustic telemetry data produced by an implantable medical device over a communication channel includes a signal generator, a modulator, and an acoustic transmitter each provided in the implantable medical device. The modulator modulates a carrier signal with an information signal representative of information acquired or produced by the implantable medical device so as to produce a modulated information signal. The modulated information signal may have a frequency content that is readily accommodated by a public exchange communication channel. The transmitter transmits the modulated information signal as an acoustic information signal in a form communicable over the communication channel. The acoustic information signal may constitute telephonic tones which are directly communicable over a conventional telephone connection. The acoustic information signal may constitute digital telephonic tones each having a frequency and format that conforms to one or more telephony standards. In an embodiment in which the communication channel constitutes a public exchange communication channel, the acoustic information signal preferably has a frequency content that is band limited by an audio bandwidth of the public exchange communication channel. A number of different modulation techniques may be employed, including phase modulation, amplitude modulation or frequency modulation. Implantable medical devices which may incorporate telemetry circuitry of the present invention include a pacemaker, a pacemaker/cardioverter/defibrillator (PCD), an oxygen sensing device, an implantable hemodynamic monitor, a muscle stimulator device or a nerve stimulator device.

    摘要翻译： 用于通过通信信道传送由可植入医疗装置产生的声学遥测数据的装置和方法包括每个设置在可植入医疗装置中的信号发生器，调制器和声发射器。 调制器利用表示由可植入医疗装置获取或产生的信息的信息信号来调制载波信号，以产生调制信息信号。 调制信息信号可以具有容易由公共交换通信信道容纳的频率内容。 发射机将调制信息信号作为在通信信道上可通信的形式的声信息信号发送。 声信息信号可以构成通过常规电话连接直接通信的电话音。 声信息信号可以构成每个具有符合一个或多个电话标准的频率和格式的数字电话音。 在通信信道构成公共交换通信信道的实施例中，声信息信号优选地具有由公共交换通信信道的音频带宽限制的频带内容。 可以采用多种不同的调制技术，包括相位调制，幅度调制或频率调制。 可包含本发明的遥测电路的可植入医疗装置包括起搏器，起搏器/心律转复器/除颤器（PCD），氧气感测装置，可植入血液动力学监测器，肌肉刺激器装置或神经刺激装置。