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67 条记录 (耗时 0.036 秒)

    Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof
    61.
    发明授权
    Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof 失效
    抑制磷酸酶活性的方法和使用萘普生及其衍生物治疗与其相关的病症

    公开(公告)号：US5602171A

    公开(公告)日：1997-02-11

    申请号：US481955

    申请日：1995-06-07

    申请人： Peng C. Tang ,  Gerald McMahon

    发明人： Peng C. Tang ,  Gerald McMahon

    IPC分类号： C07D311/92 ,  A61K31/35 ,  C07D309/32

    CPC分类号： C07D311/92

    摘要： The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.

    摘要翻译： 本发明涉及能抑制蛋白酪氨酸磷酸酶活性的有机分子。 本发明还涉及通过抑制蛋白酪氨酸磷酸酶活性来调节或调节信号转导的这种分子的用途。 最后，本发明涉及这种分子用于治疗包括糖尿病在内的各种疾病状态的用途。

    Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
    63.
    发明授权
    Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds 有权
    用吲哚啉酮化合物调节c-kit酪氨酸蛋白激酶功能的方法

    公开(公告)号：US07211600B2

    公开(公告)日：2007-05-01

    申请号：US11205474

    申请日：2005-08-16

    申请人： Ken Lipson ,  Gerald McMahon

    发明人： Ken Lipson ,  Gerald McMahon

    IPC分类号： A01N43/38

    CPC分类号： A61K31/404 ,  A61K31/00 ,  A61K31/405

    摘要： The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity c-kit kinase.

    摘要翻译： 本发明涉及化合物及其抑制受体酪氨酸激酶活性的用途。 本发明优选用于治疗细胞增殖性疾病，例如以过度活动或不适当的活性c-kit激酶​​为特征的癌症。

    Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds
    66.
    发明授权
    Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds 失效
    用5-氮杂喹喔啉类化合物调节丝氨酸/苏氨酸蛋白激酶功能的方法

    公开(公告)号：US06180631B2

    公开(公告)日：2001-01-30

    申请号：US09166723

    申请日：1998-10-05

    申请人： Gerald McMahon ,  Heinz Weinberger ,  Bernhard Kutscher ,  Harald App

    发明人： Gerald McMahon ,  Heinz Weinberger ,  Bernhard Kutscher ,  Harald App

    IPC分类号： A01N4358

    CPC分类号： C07D471/04 ,  A61K31/4985

    摘要： The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with 5-azaquinoxaline-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to 5-azaquinoxaline compounds and pharmaceutical compositions comprising these compounds.

    摘要翻译： 本发明部分地涉及用5-氮杂喹喔啉类化合物调节丝氨酸/苏氨酸蛋白激酶的功能的方法。 该方法包括表达丝氨酸/苏氨酸蛋白激酶（例如RAF）的细胞。 此外，本发明描述了用本发明鉴定的化合物预防和治疗生物体中丝氨酸/苏氨酸蛋白激酶相关异常状况的方法。 此外，本发明涉及5-氮杂喹喔啉化合物和包含这些化合物的药物组合物。