公开(公告)号：US4511478A

公开(公告)日：1985-04-16

申请号：US550929

申请日：1983-11-10

申请人： Robert C. Nowinski ,  Allan S. Hoffman

发明人： Robert C. Nowinski ,  Allan S. Hoffman

IPC分类号： C08F290/14 ,  G01N33/545 ,  C08L89/00 ,  C08H1/00

CPC分类号： C08F290/14 ,  G01N33/545 ,  G01N2650/00 ,  Y10S436/827

摘要： A method is disclosed for the de novo synthesis of polypeptide-containing polymers. This disclosure also includes a description of, and a method for the preparation of, a class of polymerizable compounds used in the synthesis of polypeptide-containing polymers. These polymerizable compounds are chemical conjugates prepared by covalent linkage of polymerizable organic monomers with specific polypeptides. Soluble monomer/polypeptide conjugates can be polymerized in solution with additional nonderivatized organic monomers to form desired polypeptide-containing polymers. The amount and composition of monomer and monomer/polypeptide conjugates can be varied in order to provide control of (a) molecular spacing, steric accessibility, and number of polypeptide molecules that are integrally incorporated into the polymer backbone, and (b) the chemical and physical structure of the polymer itself. This enables the specific tailoring of polypeptide-containing polymers for particular end-use applications.

摘要翻译： 公开了用于从头合成含多肽的聚合物的方法。 本公开还包括用于合成含多肽的聚合物中使用的一类可聚合化合物的描述和制备方法。 这些可聚合化合物是通过可聚合有机单体与特定多肽的共价连接制备的化学共轭物。 可溶性单体/多肽缀合物可以在溶液中与另外的非衍生化有机单体聚合以形成所需的含多肽的聚合物。 可以改变单体和单体/多肽缀合物的量和组成，以便提供（a）分子间距，空间可及性和整体并入到聚合物主链中的多肽分子的数量的控制，和（b）化学和/ 聚合物本身的物理结构。 这使得能够特定定制含多肽的聚合物用于特定的最终用途应用。