公开(公告)号：US5211637A

公开(公告)日：1993-05-18

申请号：US778081

申请日：1991-12-06

申请人： Yasuhiro Goto ,  Shin-ichi Hirano ,  Kiyoshi Asai

发明人： Yasuhiro Goto ,  Shin-ichi Hirano ,  Kiyoshi Asai

IPC分类号： A61M39/00 ,  A61B17/00 ,  A61B17/12 ,  A61M25/00 ,  A61M39/12

CPC分类号： A61B17/12022 ,  A61B17/12136 ,  A61M25/0014 ,  A61M39/12 ,  A61B17/00491 ,  A61B2017/00477 ,  Y10S128/912

摘要： A device for connecting a catheter to an injection tube, which is provided with an elastic tube into which an open end of the tubular catheter having electrodes disposed at the closed end thereof and also having conductive wires connected to said electrodes and taken out at the open end thereof and an open end of the injection tube having a mechanism for fluid injection at the other end thereof are inserted so that both open ends are connected end-to-end and the conductive wires are taken out through a gap between the elastic tube and the injection tube; and a sealing agent to cover respective surfaces of the catheter, injection tube, and elastic tube which surfaces are coated with an adhesive. The catheter, injection tube, and elastic tube, when coated with an adhesive of high viscosity, are compatible with the hard sealing agent lying thereabove. A casing consisting of half members encloses the sealing agent and the casing increases the strength of the device, whereby the device is prevented from being deformed and prevented from causing leakage of fluid through the gap even when subjected to external force. The device has improved resistance to external pressure. In addition, connection of the conductive wires between the electrodes and the terminals arranged on the side of the casing serves to tightly fix the wires in the sealing agent packed in the case and causes no breakage of the wires, whereby the wires are connected to the external parts through the terminals to thereby provide a device with improved reliability.

公开(公告)号：US4644157A

公开(公告)日：1987-02-17

申请号：US471708

申请日：1983-03-03

申请人： Kuniichi Ozawa ,  Yasuhiro Goto ,  Hiromi Nakase ,  Shinya Yukino

发明人： Kuniichi Ozawa ,  Yasuhiro Goto ,  Hiromi Nakase ,  Shinya Yukino

IPC分类号： G01D5/245 ,  G01P3/486 ,  G01P13/04 ,  G01D5/34

CPC分类号： G01P3/486 ,  G01D5/2451 ,  G01P13/045

摘要： An optical rotation detecting apparatus for a bushless dc motor detects rotation information of the shaft by the slits arranged at equal pitches along the circumference of a rotary disk and a photoelectric conversion element arranged circumferentially at a pitch which is an integral multiple of the slit pitch and including a first set of photoelectric conversion element pieces arranged alternately with the former thereby generating a first rotation information signal having a frequency proportional to the rotational speed of the shaft and a second rotation information signal having a 90-degree phase difference with the first rotation information signal. The phases of the first and second rotation information signals are compared to detect the direction of rotation of the shaft. The accuracy of rotation information can be further improved by increasing the number of photoelectric conversion element pieces per slit pitch. The photoelectric conversion element includes an amorphous silicon photoelectric conversion element.

摘要翻译： 用于无衬套直流电动机的光学旋转检测装置通过沿旋转盘的圆周等间距布置的狭缝和以每个狭缝间距的整数倍的间距周向布置的光电转换元件来检测轴的旋转信息，以及 包括与前者交替布置的第一组光电转换元件片，从而产生具有与轴的转速成比例的频率的第一旋转信息信号和与第一旋转信息成90度相位差的第二旋转信息信号 信号。 比较第一和第二旋转信息信号的相位以检测轴的旋转方向。 通过增加每个狭缝间距的光电转换元件的数量，可以进一步提高旋转信息的精度。 光电转换元件包括非晶硅光电转换元件。

公开(公告)号：US08207169B2

公开(公告)日：2012-06-26

申请号：US12995832

申请日：2009-05-28

申请人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

发明人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

IPC分类号： A61K31/495

CPC分类号： C07D471/14

摘要： The compounds of Formula D are of the class of triazolo-pyrido-pyrazines which are inhibitors of AKT useful for the treatment of cancer

摘要翻译： 式D的化合物是三唑并 - 吡啶并吡嗪类，其是可用于治疗癌症的AKT抑制剂

公开(公告)号：US20110092511A1

公开(公告)日：2011-04-21

申请号：US12995832

申请日：2009-05-28

申请人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

发明人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

IPC分类号： A61K31/4985 ,  C07D471/14 ,  A61K31/4375 ,  C07D403/14 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D471/14

摘要： The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity especially Akt1 by administering the compound to a patient in need of treatment of cancer.

摘要翻译： 本发明提供抑制Akt活性的取代的萘啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型，优选Akt1。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性，尤其是Akt1的方法。

公开(公告)号：US07836304B2

公开(公告)日：2010-11-16

申请号：US11491301

申请日：2006-07-24

申请人： Koichiro Akiyama ,  Yasuhiro Goto

发明人： Koichiro Akiyama ,  Yasuhiro Goto

IPC分类号： H04L9/00

CPC分类号： H04L9/3263 ,  H04L9/0861 ,  H04L9/3033 ,  H04L9/3066 ,  H04L9/3093 ,  H04L9/3247 ,  H04L9/3281

摘要： A digital signature generation apparatus includes memory to store finite field Fq and section D(ux(s, t), uy(s, t), s, t) as secret key, section being one of surfaces of three-dimensional manifold A(x, y, s, t) which is expressed by x-coordinate, y-coordinate, parameter s, and parameter t and is defined on finite field Fq, x-coordinate and y-coordinate of section being expressed by functions of parameter s and parameter t, calculates hash value of message m, generates hash value polynomial by embedding hash value in 1-variable polynomial h(t) defined on finite field Fq, and generates digital signature Ds(Ux(t), Uy(t), t) which is curve on section, the x-coordinate and y-coordinate of curve being expressed by functions of parameter t, by substituting hash value polynomial in parameter s of section.

摘要翻译： 数字签名生成装置包括存储器，用于存储有限域Fq和区段D（ux（s，t），uy（s，t），s，t）作为秘密密钥，区段是三维歧管A的表面之一 x，y，s，t），由x坐标，y坐标，参数s和参数t表示，并定义在有限域Fq，x坐标和y坐标的区间由参数s的函数表示 和参数t计算消息m的哈希值，通过在有限域Fq上定义的1变量多项式h（t）中嵌入哈希值来生成哈希值多项式，生成数字签名Ds（Ux（t），Uy（t） t），曲线的x坐标和y坐标由参数t的函数表示，通过在段的参数s中代入散列值多项式。

公开(公告)号：US07834019B2

公开(公告)日：2010-11-16

申请号：US11789548

申请日：2007-04-25

申请人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/519 ,  A61K31/497 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US07787623B2

公开(公告)日：2010-08-31

申请号：US11565204

申请日：2006-11-30

申请人： Koichiro Akiyama ,  Yasuhiro Goto

发明人： Koichiro Akiyama ,  Yasuhiro Goto

IPC分类号： H04L9/22

CPC分类号： H04L9/3093 ,  H04L9/002 ,  H04L9/3026 ,  H04L2209/08

摘要： A key generating apparatus generates a fibration X(x, y, t)=0 of an algebraic surface X serving as a part of a public key and defined on a finite field Fq (where q=pr [p is a prime number and r is an extended degree]) and a private key which is two sections D1 and D2 corresponding to the fibration X(x, y, t)=0. The fibration X(x, y, t) is generated such that a term (cij(t)xiyj) of xiyj having a 1-variable polynomial cij(t) of t as a coefficient is included in the fibration X(x, y, t).

摘要翻译： 密钥生成装置生成用作公钥的一部分的代数表面X的振动X（x，y，t）= 0，并定义在有限域Fq上（其中q = pr [p是素数，r 是扩展度]）和私钥，它是与振动X（x，y，t）= 0对应的两个部分D1和D2。 产生振动X（x，y，t），使得具有作为系数的t的1变量多项式cij（t）的xiyj的项（cij（t）xiyj）被包括在振动X（x，y ，t）。

公开(公告)号：US07773747B2

公开(公告)日：2010-08-10

申请号：US11426450

申请日：2006-06-26

申请人： Koichiro Akiyama ,  Yasuhiro Goto

发明人： Koichiro Akiyama ,  Yasuhiro Goto

IPC分类号： H04L9/30 ,  H04L9/14

CPC分类号： H04L9/3026 ,  H04L2209/08

摘要： A method whereby an encryption apparatus encrypts a message on the basis of a fibration X(x, y, t) serving as a public key when private keys are two or more sections corresponding to fibration X(x, y, t)=0 of an algebraic surface X, the method comprises embedding plaintext M obtained by concatenating the message to a random number as the coefficients of plaintext polynomial M(t) of degree l−1 or less, and generating encrypted text F=Epk(M, p, q, f, X) from the plaintext polynomial M(t) by an encrypting process of performing operations including at least one of addition, subtraction, and multiplication of random polynomials p(x, y, t), q(x, y, t), a random irreducible polynomial f(t) of degree l or more, and the fibration X(x, y, t) with respect to the plaintext polynomial M(t).

摘要翻译： 当私钥为对应于振动X（x，y，t）= 0的两个或多个部分时，加密装置基于作为公共密钥的振动X（x，y，t）加密消息的方法 代数表面X，该方法包括将通过将消息连接到随机数而获得的明文M作为l-1或更小的明文多项式M（t）的系数，并且生成加密文本F = Epk（M，p， 通过执行包括随机多项式p（x，y，t），q（x，y，t），q（x，y）的加法，减法和乘法中的至少一个的操作的加密处理，从明文多项式M（t） t），1或更大的随机不可约多项式f（t）以及相对于明文多项式M（t）的振动X（x，y，t）。

公开(公告)号：US07321715B2

公开(公告)日：2008-01-22

申请号：US10619261

申请日：2003-07-14

申请人： Kenji Yamasaki ,  Yasuhiro Goto ,  Fumiyoshi Abe

发明人： Kenji Yamasaki ,  Yasuhiro Goto ,  Fumiyoshi Abe

IPC分类号： H04N5/91 ,  H04N7/26

CPC分类号： H04N9/8042 ,  H04N5/783

摘要： In a picture data reproducing method of reproducing picture data recorded to a recording medium according the MPEG standard, there is provisionally stored, into a stream buffer, picture data grouped as a GOP which begins with an I picture, the picture data provisionally stored in the stream buffer is read sequentially starting with a previous picture and the read picture data is decoded in the course of a FORWARD reproduction being done, and picture data acquired from the recording medium is additionally supplied to the stream buffer. When the picture data provisionally stored in the stream buffer have been read in the decoding step to before last N frames, a predetermined amount of picture data is additionally supplied, in the data adding step, beginning at the head of a GOP including picture data in the remaining N-th frame in the stream buffer. Thus, a smooth variable-speed reproduction can be done according to the MPEG Standard.

摘要翻译： 在根据MPEG标准再现记录在记录介质上的图象数据的图象数据再现方法中，临时存储在流缓冲器中，以GOP为开始的图像数据，该GOP以I图象开始，临时存储在 流缓冲器从先前图像开始顺序读取，并且读取的图像数据在进行正向再现的过程中被解码，并且从记录介质获取的图像数据被附加地提供给流缓冲器。 当在解码步骤中临时存储在流缓冲器中的图像数据已被读取到最后N帧之前时，在数据添加步骤中，在包括图像数据的GOP的头部开始附加地提供预定量的图像数据 流缓冲器中剩余的第N帧。 因此，可以根据MPEG标准进行平滑的可变速度再现。

公开(公告)号：US07239795B2

公开(公告)日：2007-07-03

申请号：US10619271

申请日：2003-07-14

申请人： Kenji Yamasaki ,  Yasuhiro Goto ,  Fumiyoshi Abe ,  Munehiro Shimomura

发明人： Kenji Yamasaki ,  Yasuhiro Goto ,  Fumiyoshi Abe ,  Munehiro Shimomura

IPC分类号： H04N5/91 ,  H04N7/26

CPC分类号： H04N21/44004 ,  H04N5/783 ,  H04N9/8042 ,  H04N21/440281

摘要： In an STC generating step, STCs (STC_d) delayed a time “System_delay” from STC (STC_medium) in compressed picture data read from a recording medium in the normal-speed reproduction mode is sequentially generated. In this STC generating step, there is set at shift from a variable-speed reproduction to normal-speed reproduction an STC initial value on the basis of results of comparison between PTS (PTS_s) in display picture data at the time of reproduction mode shift and {STC_medium at the shift−(delay due to the shift (shift_delay)+System_delay)}. Thus, when shifting the reproduction mode from a variable-speed one to normal-sped one in compliance with the MPEG standard, pictures can smoothly be displayed in the normal-speed reproduction mode without skipping over any displayed pictures.

摘要翻译： 在STC生成步骤中，STC（STC_d）在从正常速度再现模式中从记录介质读取的压缩图像数据中顺序生成STC（STC_medium）时间“System_delay”。 在该STC生成步骤中，基于再现模式移位时的显示图像数据中的PTS（PTS_s）与再现模式移位时的比较结果与 {STC_medium at shift-（由于shift（shift_delay延迟）+ System_delay）}。 因此，当根据MPEG标准将再现模式从可变速度转换为正常速度时，图像可以平滑地以正常速度再现模式显示，而不跳过任何显示的图像。