公开(公告)号：US20200371329A1

公开(公告)日：2020-11-26

申请号：US16677115

申请日：2019-11-07

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Nathan BECKETT ,  Nathan CASWELL ,  Jacob A. WOLF ,  Gene POLOVY ,  Denis PRISTINSKI

IPC: G02B21/00 ,  G01N33/00 ,  G01N1/28

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

公开(公告)号：US20190271039A1

公开(公告)日：2019-09-05

申请号：US16416889

申请日：2019-05-20

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Kristopher BARBEE ,  Nathan BECKETT

IPC: C12Q1/6874 ,  G01N33/543 ,  C12Q1/6809 ,  B01L3/00 ,  B01J19/00 ,  C12Q1/6825

Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

公开(公告)号：US20190271038A1

公开(公告)日：2019-09-05

申请号：US16416856

申请日：2019-05-20

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Kristopher BARBEE ,  Nathan BECKETT

IPC: C12Q1/6874 ,  G01N33/543 ,  C12Q1/6809 ,  B01L3/00 ,  B01J19/00 ,  C12Q1/6825

Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

公开(公告)号：US20190153520A1

公开(公告)日：2019-05-23

申请号：US15974543

申请日：2018-05-08

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher BARBEE ,  Nathan BECKETT ,  Denis PRISTINSKI ,  Derek SCHULTE ,  Avishai BARTOV ,  Jamie SULLIVAN ,  Dumitru BRINZA ,  Abizar LAKDAWALLA ,  Steven MENCHEN ,  Gilad ALMOGY ,  Mark PRATT

IPC: C12Q1/6825 ,  B01L3/00

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.