公开(公告)号：US4021479A

公开(公告)日：1977-05-03

申请号：US406196

申请日：1973-10-15

申请人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

发明人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

IPC分类号： C07C57/58 ,  C07C63/333 ,  C07C65/14

CPC分类号： C07C205/56 ,  C07C57/58 ,  Y10S514/916

摘要： Compounds of the formulas ##STR1## and ##STR2## wherein A is --CH.sub.2 -- or --CH(OH)--,R.sub.1 is hydrogen, halogen or, when R.sub.2 and R.sub.3 are other than both hydrogen, also methyl,R.sub.2 is hydrogen, halogen, cyano, nitro, amino or (alkanoyl of 1 to 4 carbon atoms)-amino,R.sub.3 is hydrogen or halogen,Provided, however, that at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen, andR.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, and non-toxic salts of the free acids (R.sub.4 = H) formed with inorganic or organic bases; the compounds as well as their salts are useful as antiphlogistics and antiproliferatives.

摘要翻译： 其中A是-CH 2 - 或-CH（OH） - ，R 1是氢，卤素，或者当R 2和R 3不同于氢时，也是甲基，R 2是氢，卤素 ，氰基，硝基，氨基或（1至4个碳原子的烷酰基） - 氨基，R3是氢或卤素，提供，然而，至少一个R 1，R 2和R 3不是氢，并且R 4是氢或烷基 1至4个碳原子的无毒盐和无机或有机碱形成的游离酸（R4 = H）的无毒盐; 化合物及其盐可用作消炎剂和抗增殖剂。

公开(公告)号：US3997589A

公开(公告)日：1976-12-14

申请号：US543266

申请日：1975-01-23

申请人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

发明人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

IPC分类号： C07C57/58 ,  C07C65/20 ,  C07C69/76

CPC分类号： C07C57/58

摘要： Compounds of the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 4 carbon atoms, and, when R is hydrogen, non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antiphlogistics and antiproliferatives.

摘要翻译： 其中R是氢或1至4个碳原子的烷基，当R是氢时，其无机盐与无机或有机碱形成; 化合物以及盐可用作消炎剂和抗增殖剂。