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    Derivatives of 4-(4-biphenylyl)-butyric acid
    4.
    发明授权
    Derivatives of 4-(4-biphenylyl)-butyric acid 失效
    4-（4-联苯基） - 丁酸的衍生物

    公开(公告)号：US4021479A

    公开(公告)日：1977-05-03

    申请号：US406196

    申请日：1973-10-15

    申请人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

    发明人： Ernst Seeger ,  Wolfhard Engel ,  Josef Nickl ,  Helmut Teufel

    IPC分类号： C07C57/58 ,  C07C63/333 ,  C07C65/14

    CPC分类号： C07C205/56 ,  C07C57/58 ,  Y10S514/916

    摘要： Compounds of the formulas ##STR1## and ##STR2## wherein A is --CH.sub.2 -- or --CH(OH)--,R.sub.1 is hydrogen, halogen or, when R.sub.2 and R.sub.3 are other than both hydrogen, also methyl,R.sub.2 is hydrogen, halogen, cyano, nitro, amino or (alkanoyl of 1 to 4 carbon atoms)-amino,R.sub.3 is hydrogen or halogen,Provided, however, that at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen, andR.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, and non-toxic salts of the free acids (R.sub.4 = H) formed with inorganic or organic bases; the compounds as well as their salts are useful as antiphlogistics and antiproliferatives.

    摘要翻译： 其中A是-CH 2 - 或-CH（OH） - ，R 1是氢，卤素，或者当R 2和R 3不同于氢时，也是甲基，R 2是氢，卤素 ，氰基，硝基，氨基或（1至4个碳原子的烷酰基） - 氨基，R3是氢或卤素，提供，然而，至少一个R 1，R 2和R 3不是氢，并且R 4是氢或烷基 1至4个碳原子的无毒盐和无机或有机碱形成的游离酸（R4 = H）的无毒盐; 化合物及其盐可用作消炎剂和抗增殖剂。

    Method of synthesis of water soluble fullerene polyacids using a malonate reactant
    7.
    发明申请
    Method of synthesis of water soluble fullerene polyacids using a malonate reactant 审中-公开
    使用丙二酸酯反应物合成水溶性富勒烯多元酸的方法

    公开(公告)号：US20060047167A1

    公开(公告)日：2006-03-02

    申请号：US11214468

    申请日：2005-08-29

    申请人： Andreas Hirsch ,  Florian Beuerle ,  Nikos Chronakis

    发明人： Andreas Hirsch ,  Florian Beuerle ,  Nikos Chronakis

    IPC分类号： C07C63/333 ,  C07C69/76

    CPC分类号： C07C67/297 ,  C07C67/31 ,  C07C2604/00 ,  C07D493/22 ,  C07C69/753 ,  C07C69/732

    摘要： In one embodiment, the present invention is directed to a method for synthesizing compounds of the formula where Cm is a fullerene having m carbon atoms, the method comprising the steps of forming a linear malonate compound of the formula where each Z is the same or different and is a straight-chain or branched-chain aliphatic radical having from 1-30 carbon atoms which may be unsubstituted or monosubstituted or polysubstituted by identical or different substitutents, in which radicals up to every third —CH2— unit can be replaced by O or NR″, n is an integer from 2 to 10, and the unfilled valences of the first and nth malonate groups are filled with bonds to hydrogen, a hydrocarbon group or substituted hydrocarbon group having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups; or (ii) a branched malonate compound of the formula where Z′ is an aliphatic radical having from 1-30 carbon atoms which may be unsubstituted or monosubstituted or polysubstituted by identical or different substitutents, in which radicals up to every third —CH2— unit can be replaced by O or NR″; and n is an integer from 2 to 10; reacting said malonate compound with Cm to form an adduct of the formula each Z is bonded to both one carboxylate group of a first malonate moiety and one carboxylate group of a second malonate moiety and the unfilled valences of the first and nth malonate groups are filled with bonds to hydrogen, a hydrocarbon group or substituted hydrocarbon group having 1-20 carbon atoms, or a chain containing unsubstituted or substituted aryl or other cyclic groups; and hydrolyzing said adduct to form the compound.

    摘要翻译： 在一个实施方案中，本发明涉及一种合成下式的化合物的方法，其中C m是具有m个碳原子的富勒烯，该方法包括以下步骤：形成下式的线性丙二酸酯化合物 其中每个Z相同或不同，并且是具有1-30个碳原子的直链或支链脂族基团，其可以是未取代的或被相同或不同取代基单取代或多取代的，其中自由基直到每第三个-CH 单元可以被O或NR“替代，n是2至10的整数，第一和第n丙二酸酯基团的未填充的化合价用氢键连接，烃基 或具有1-20个碳原子的取代烃基，或含有未取代或取代的芳基或其它环状基团的链; 或（ii）下式的支链丙二酸酯化合物其中Z'是具有1-30个碳原子的脂族基团，其可以是未取代的或被相同或不同取代基单取代或多取代的，其中自由基直到每第三个-CH 2 - 可以用O或NR“代替单位; n为2〜10的整数。 使所述丙二酸酯化合物与C m 2反应以形成下式的加合物，其中每个Z键合到第一丙二酸酯部分的一个羧酸酯基团和一个第二丙二酸酯部分的一个羧酸酯基团， 第一和第n丙二酸酯基团与氢，烃基或具有1-20个碳原子的取代烃基的键或含有未取代或取代的芳基或其它环状基团的链填充; 并水解所述加合物以形成化合物。