公开(公告)号：US20050255041A1

公开(公告)日：2005-11-17

申请号：US10846266

申请日：2004-05-13

申请人： David Young ,  Susan Hahn ,  Helen Findlay

发明人： David Young ,  Susan Hahn ,  Helen Findlay

IPC分类号： A61K39/395 ,  A61K47/48 ,  A61K51/00 ,  A61K51/10 ,  A61P35/00 ,  C07K16/00 ,  C07K16/30 ,  C12N5/12 ,  G01N33/574

CPC分类号： A61K51/1051 ,  A61K47/6855 ,  C07K16/00

摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

公开(公告)号：US20050063967A1

公开(公告)日：2005-03-24

申请号：US10949846

申请日：2004-09-24

申请人： David Young ,  Susan Hahn ,  Helen Findlay ,  Alison Ferry

发明人： David Young ,  Susan Hahn ,  Helen Findlay ,  Alison Ferry

IPC分类号： A61K51/10 ,  C07K16/00 ,  C07K16/30 ,  G01N33/574 ,  A61K39/395

CPC分类号： G01N33/57492 ,  A61K47/6851 ,  A61K51/1045 ,  A61K51/1051 ,  A61K51/1096 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/00 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/34 ,  C12N9/1051 ,  G01N33/56966 ,  G01N33/5743 ,  G01N33/57484

摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMABs of the instant invention.

摘要翻译： 本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用任选与一种或多种化学治疗剂组合的癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。 本发明还涉及利用本发明的CDMABs的结合测定法。

公开(公告)号：US20040253653A1

公开(公告)日：2004-12-16

申请号：US10892597

申请日：2004-07-15

申请人： Arius Research, Inc.

发明人： David S.F. Young ,  Susan E. Hahn ,  Helen P. Findlay

IPC分类号： C12Q001/68 ,  G01N033/574 ,  A61K039/395

CPC分类号： C07K16/3046 ,  A61K51/1045 ,  A61K51/1051 ,  A61K51/1096 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3069 ,  G01N33/574 ,  G01N33/57484

摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.