公开(公告)号：US20230244000A1

公开(公告)日：2023-08-03

申请号：US18101318

申请日：2023-01-25

申请人： Bausch + Lomb Ireland Limited

发明人： Alok Kumar Awasthi ,  Feng-Yang Shih ,  Mohammad Vatankhah Varnosfaderani ,  James Anthony DiBella, JR. ,  Mark R. Mis ,  Jade J. Russell

IPC分类号： G02B1/04 ,  G02C7/04

CPC分类号： G02B1/043 ,  G02C7/04

摘要： A multifunctional crosslinking agent includes one or more repeating units of a siloxanyl group or a silyl-alkyl-siloxanyl group, and at least two ethylenically unsaturated reactive end groups. One of the at least two ethylenically unsaturated reactive end groups is a (meth)acrylate-containing reactive end group or an acrylamide-containing reactive end group and the other one is an allyl-containing reactive end group or a vinyl-containing reactive end group. Ophthalmic devices are formed from a polymerization product of a monomeric mixture containing one or more of the multifunctional crosslinking agents, one or more first ophthalmic device-forming comonomers having at least one reactive group that preferentially reacts with the (meth)acrylate-containing reactive end group or the acrylamide-containing reactive end group of the multifunctional crosslinking agent, and one or more second ophthalmic device-forming comonomers having at least one reactive group that preferentially reacts with the allyl-containing reactive end group or the vinyl-containing reactive end group of the multifunctional crosslinking agent.

公开(公告)号：US20230096315A1

公开(公告)日：2023-03-30

申请号：US17836299

申请日：2022-06-09

申请人： Bausch + Lomb Ireland Limited

发明人： Alok Kumar Awasthi ,  Kristen Rae Hovinga ,  Emily Abrams Gabriel ,  Kevin Jacob DeRyke ,  Jade J. Russell

IPC分类号： C08F126/10 ,  A61L27/50 ,  C08J7/14 ,  C09B62/83

摘要： A method for preparing an ophthalmic device for slowing, inhibiting or preventing myopia progression involves contacting an ophthalmic device having one or more reactive functional groups with one or more red-light blocking compounds having one or more reactive functional groups complementary to the one or more reactive functional groups of the ophthalmic device in a basic solution for a time period sufficient to covalently bond at least one reactive functional group of the ophthalmic device with at least one reactive functional group of the one or more red-light blocking compounds. The one or more red-light blocking compounds block greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nanometers (nm) to about 800 nm.

公开(公告)号：US20230089707A1

公开(公告)日：2023-03-23

申请号：US17836282

申请日：2022-06-09

申请人： Bausch + Lomb Ireland Limited

发明人： Alok Kumar Awasthi ,  Kristen Rae Hovinga ,  Emily Abrams Gabriel ,  Kevin Jacob DeRyke ,  Jade J. Russell ,  James Anthony DiBella, JR. ,  Alana Ingham

IPC分类号： C08F283/06 ,  A61L27/50 ,  A61L27/16 ,  C08F283/12 ,  C08K5/42 ,  C08K5/18 ,  C08F226/10

摘要： An ophthalmic device for slowing, inhibiting or preventing myopia progression which is a polymerization product of a monomeric mixture comprising (a) greater than 50 wt. %, based on the total weight of the monomeric mixture, of one or more non-silicone-containing hydrophilic monomers; (b) one or more crosslinking agents; and (c) one or more red-light blocking compounds blocking greater than 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nm to about 800 nm, wherein the one or more red-light blocking compounds have one or more ethylenically unsaturated reactive end groups.

公开(公告)号：US20230060534A1

公开(公告)日：2023-03-02

申请号：US17462962

申请日：2021-08-31

申请人： Bausch + Lomb Ireland Limited

发明人： Baxter J. LANSING ,  Arvind M. RAO ,  James DIBELLA ,  Joseph W. HOFF

IPC分类号： A45C11/00

摘要： A contact lens package includes a first layer, a support coupled to the first layer, a lens, and a second layer. The support includes a scaffold and a porous member attached to the scaffold where the porous member includes a curved surface. The lens includes an anterior surface and a posterior surface, and the posterior surface of the lens is disposed on the curved surface of the porous member. The second layer is coupled to the first layer to seal the support and the lens between the first layer and the second layer.

公开(公告)号：US20220288270A1

公开(公告)日：2022-09-15

申请号：US17689380

申请日：2022-03-08

申请人： Bausch + Lomb Ireland Limited

发明人： Katie L. Poetz ,  Ivan M. Nuñez ,  Analuz Mark ,  Grace Bennett ,  Robert Steffen ,  Andrew J. Hoteling ,  Michelle Piotrowski ,  Brendan Shannon ,  Keyla Cubi ,  Alana Ingham

IPC分类号： A61L12/08 ,  A61L12/14 ,  A61L2/04

摘要： A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes one or more conjugated glycosaminoglycans having a polymer backbone having a reactive functional moiety conjugated to an amine group having one or more moieties that inhibit and/or prevent one or more of oxidation and hydrolytic degradation of the polymer backbone during use in the eye; wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

公开(公告)号：US20220137432A1

公开(公告)日：2022-05-05

申请号：US17089233

申请日：2020-11-04

申请人： Bausch + Lomb Ireland Limited

发明人： Kristen Hovinga ,  Mohammad Musleh ,  Mengchen Xu

IPC分类号： G02C7/04

摘要： An ophthalmic lens, comprising a central zone having at least a first power, and a peripheral zone having an add-power offset relative to the at least first power and a spatially-modulated optical parameter. In some embodiments, the central zone has a diameter in the range 2.0 to 5.0 mm. In some embodiments, the central zone is not more than 1 mm smaller than a wearer's pupil. The spatially-modulated optical parameter may include optical power, light scattering or light transmission.