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公开(公告)号：US10428328B2
公开(公告)日：2019-10-01
申请号：US14667285
申请日：2015-03-24
IPC分类号： C12N15/11 , C12N15/113 , A61K48/00 , C07H21/02 , C07H21/04 , A61K31/7105 , A61K45/06
摘要： Oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, compositions including the oligonucleotides, kits including the compositions, and uses thereof. Compositions of oligonucleotides useful in methods for suppressing exon 10 skipping optionally in combination with additional CFTR therapeutics.
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公开(公告)号：US20190209466A1
公开(公告)日：2019-07-11
申请号：US16326954
申请日：2017-09-03
申请人： DEXCEL PHARMA TECHNOLOGIES LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
发明人： Simon BENITA , Taher NASSAR
IPC分类号： A61K9/00 , A61K47/38 , A61K47/36 , A61P27/02 , A61P31/04 , A61K31/575 , A61K47/26 , A61K47/10 , A61K47/02 , A61K47/18
CPC分类号： A61K9/0048 , A61K9/06 , A61K31/575 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/183 , A61K47/186 , A61K47/26 , A61K47/36 , A61K47/38 , A61P27/02 , A61P31/04
摘要： An ophthalmic composition useful for the treatment of bacterial eye infections is provided. The ophthalmic composition includes the suspension of particles of active anti-bacterial agent in a gelled matrix.
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公开(公告)号：US20190201478A1
公开(公告)日：2019-07-04
申请号：US16295334
申请日：2019-03-07
发明人： Simon BENITA , Taher NASSER , Nour KARRA , Amit BADIHI
IPC分类号： A61K38/13 , A61K9/50 , A61K9/16 , A61K49/00 , A61K8/11 , A61Q19/00 , A61K8/85 , C07C323/57 , A61K38/28 , A61K38/23 , A61K31/573 , A61K9/00 , A61K39/395 , A61K31/575 , A61K9/14
CPC分类号： A61K38/13 , A61K8/11 , A61K8/85 , A61K9/0014 , A61K9/146 , A61K9/1647 , A61K9/5031 , A61K31/573 , A61K31/575 , A61K38/23 , A61K38/28 , A61K39/3955 , A61K49/0054 , A61K2800/10 , A61K2800/412 , A61K2800/413 , A61K2800/56 , A61Q19/00 , C07C323/57 , Y10T428/2982
摘要： Provided is a nanoparticle associated with a plurality of oleylcysteineamide (OCA) molecules for a variety of therapeutic applications. At least a portion of the OCA molecules may be associated with at least one therapeutic agent or at least one non-active agent. Also provided is a drug delivery agent including at least one nanoparticle associated with a plurality of OCA molecules. At least a portion of the OCA molecules is associated with at least one therapeutic agent or at least one or non-active agent. Also provided is a method of delivering a drug to a subject. The method includes administering the drug delivery agent (associated with the drug) to the subject.
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公开(公告)号：US20190169686A1
公开(公告)日：2019-06-06
申请号：US16214710
申请日：2018-12-10
发明人： Danny PORATH , Oded SHOSEYOV , Yuval NEVO , Ke LIU , Dvir MAROM ROTEM
IPC分类号： C12Q1/6869 , G01N33/487 , G01N27/447
CPC分类号： C12Q1/6869 , G01N27/44704 , G01N27/44756 , G01N33/48721
摘要： The invention relates to a hybrid structure comprising perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.
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公开(公告)号：US20190164302A1
公开(公告)日：2019-05-30
申请号：US16242186
申请日：2019-01-08
发明人： Shmuel PELEG , Yair POLEG , Tavi HALPERIN , Chetan ARORA
摘要： A method and a system for generating adaptive fast forward of egocentric videos are provided here. The method may include the following steps: obtaining a video footage containing a sequence of image frames captured by a non-stationary capturing device; estimating a moving direction of the non-stationary capturing device for a plurality of frames in the sequence of image frames; and generating a shortened video footage having fewer frames than said video footage, by sampling the sequence of image frames, wherein the sampling is carried out by selecting specific image frames and that minimize an overall cost associated with a deviation from a specific direction related to the moving direction, calculated for each of said plurality of image frames.
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公开(公告)号：US20190054176A1
公开(公告)日：2019-02-21
申请号：US15781639
申请日：2016-12-06
发明人： Elka TOUITOU
IPC分类号： A61K47/24 , A61K31/05 , A61K31/352 , A61K9/00 , A61P29/02
摘要： Provided is a composition for oral administration which includes a lipophilic active substance and a phospholipid, providing a prolonged therapeutic effect.
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公开(公告)号：US10192689B2
公开(公告)日：2019-01-29
申请号：US15541726
申请日：2016-01-07
发明人： Lioz Etgar , Shlomo Magdassi , Sigalit Aharon , Michael Layani
摘要： Provided is a continuous material pattern, the pattern is selected to have a plurality of material-free voids, the material including at least one perovskite material.
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公开(公告)号：US10179933B2
公开(公告)日：2019-01-15
申请号：US14760145
申请日：2014-02-06
发明人： Danny Porath , Oded Shoseyov , Yuval Nevo , Ke Liu , Dvir Marom Rotem
IPC分类号： C12Q1/6869 , G01N27/447 , G01N33/487
摘要： The invention relates to a hybrid structure including perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.
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公开(公告)号：US20180359981A1
公开(公告)日：2018-12-20
申请号：US16062972
申请日：2016-12-15
发明人： Zvi PELEG , Naama TEBOUL , Yaron GADRI
摘要： Provided are sesame plants having a mutation conferring closed capsules at maturity and means and methods for producing same. The plants of the present subject matter produce high yield of sesame seeds, the seeds having improved content of at least one of zinc, iron and calcium.
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公开(公告)号：US20180348563A1
公开(公告)日：2018-12-06
申请号：US16017225
申请日：2018-06-25
申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Qlight Nanotech Ltd.
发明人： Uri BANIN , Ehud SHAVIV , Hagai ARBELL
IPC分类号： G02F1/1335 , G02F1/1333 , G02B5/02 , G02F1/13363 , G02B5/30
CPC分类号： G02F1/13362 , G02B5/0242 , G02B5/0257 , G02B5/3008 , G02B5/3075 , G02F1/133308 , G02F1/133606 , G02F1/133617 , G02F1/13363 , G02F2202/36
摘要： A polarized light source configured for use in display device and backlight unit is described. The polarized light source comprising: at least one optically active structure comprising a plurality of nanorods configured to emit light of one or more wavelengths in response to exciting pumping field, said plurality of nanorods comprising nanorods aligned with a predetermined alignment axis so as to produce a desired polarization direction of the emitted light; and a light directing assembly comprising one or more optical elements in optical path of light emitted from the light emitting structure, said light directing assembly being configured to enhance output of the emitted light from the emitting structure while substantially maintaining the polarization of the emitted light passing therethrough. Preferably, layers associated with the polarized light source are aligned with parallel principal axes.
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