SILICIC ACID CONDENSATES HAVING A LOW CROSS-LINKAGE RATE
    65.
    发明申请
    SILICIC ACID CONDENSATES HAVING A LOW CROSS-LINKAGE RATE 审中-公开
    具有低交叉连接率的硅酸混合物

    公开(公告)号:US20140037958A1

    公开(公告)日:2014-02-06

    申请号:US13981599

    申请日:2012-01-31

    申请人: Thomas Gerber

    发明人: Thomas Gerber

    IPC分类号: A61L26/00 A61L27/02

    摘要: A material or biomaterial comprising silicic acid condensates with a low degree of crosslinking and methods of producing the same are subject matter of the present invention. A method of producing silicic acid structures having a low degree of crosslinking is disclosed, in which a sol is prepared, with further condensation being prevented if certain cross-linkages of the silicic acid are achieved, and wherein, preferably, structures with a size of 0.5-1000 nm are produced, e.g., polyhedral structures or aggregates of the same. Further condensation can be prevented by a chemical reaction of OH groups of the silicic acid condensates, e.g., by esterification or silylation. In one embodiment, the material primarily includes silicon dioxide (SiO2), in particular silicon dioxide that, because of its modification, e.g., by esterification, is nanostructured and has a low degree of crosslinking. The material may be used for therapeutic purposes in the field of medicine or for cosmetic purposes, and, herein, it may enter into direct contact with biological tissues in the body. In this, said material enters into chemical, physical and biological interactions with the corresponding biological systems. In this context, it can be degraded and can supply the silicic acid needed in the metabolism. It may also have a supportive or shielding effect. It may be present in the form of granules, microparticles, fibers and as woven or fleece fabrics produced from those, or as a layer on implants or wound dressings. This material may be used as a medical device or as a nutritional supplement.

    摘要翻译: 包含低交联度的硅酸缩合物的材料或生物材料及其制备方法是本发明的主题。 公开了一种制备低交联度的硅酸结构体的方法,其中制备溶胶,如果达到某些特定的硅酸交联,则可进一步缩合,并且其中优选具有尺寸为 产生0.5-1000nm,例如多面体结构或其聚集体。 可以通过硅酸缩合物的OH基团的化学反应例如通过酯化或甲硅烷基化来防止进一步的缩合。 在一个实施方案中,材料主要包括二氧化硅(SiO 2),特别是二氧化硅,由于其改性,例如通过酯化,其是纳米结构的并且具有低度交联度。 该材料可用于医学领域或用于化妆品目的的治疗目的,并且在本文中,其可以与身体中的生物组织直接接触。 在这种情况下,所述物质与相应的生物系统进入化学,物理和生物相互作用。 在这种情况下,它可能会降解,并能提供新陈代谢所需的硅酸。 它也可能具有支持或屏蔽效果。 它可以以颗粒,微粒,纤维的形式存在,以及由它们生产的编织或羊毛织物,或作为植入物或伤口敷料上的层。 该材料可以用作医疗器械或营养补充剂。