公开(公告)号：US11315685B2

公开(公告)日：2022-04-26

申请号：US15415758

申请日：2017-01-25

申请人： UCB BIOPHARMA SPRL

发明人： Kunal Malhotra ,  Sungtae An ,  Jimeng Sun ,  Myung Choi ,  Cynthia Dilley ,  Chris Clark ,  Joseph Robertson ,  Edward Han-Burgess

IPC分类号： G16H50/20 ,  A61B5/00 ,  G16H10/60 ,  G16H70/40 ,  G16H50/70

摘要： A method of building a machine learning pipeline for predicting the efficacy of anti-epilepsy drug treatment regimens is provided. The method includes providing electronic health records data; constructing a patient cohort from the electronic health records data by selecting patients based on a defined target variable indicating anti-epilepsy drug treatment regimen efficacy; constructing a set features found in or derived from the electronic health records data; electronically processing the patient cohort to identify a subset of the features that are predictive for anti-epilepsy drug treatment regimen efficacy for inclusion in predictive models configured for generating predictions representative of efficacy for a plurality of anti-epilepsy drug treatment regimens; and training the predictive computerized model to generate predictions representative of efficacy for a plurality of anti-epilepsy drug treatment regimens for the patients based on the defined target variable indicating anti-epilepsy drug treatment regimen efficacy.

公开(公告)号：US11305413B2

公开(公告)日：2022-04-19

申请号：US16630319

申请日：2018-07-18

申请人： HILTI AKTIENGESELLSCHAFT

发明人： Xi Zhou ,  Günter Haas ,  Konstantin Baxivanelis

IPC分类号： F16M1/00 ,  B25H3/00 ,  B25F5/02 ,  F16B45/00 ,  F16M13/02

摘要： A holding apparatus for being detachably attached to a machine tool housing of a machine tool and for receiving a hook for hanging the machine tool from the hook is provided. The holding apparatus has a fastening portion for fastening the holding apparatus to the machine tool housing, a securing device for securing the holding apparatus on the machine tool housing, and a receiving portion which has an opening and is intended for receiving and rotatably supporting an insertion portion of the hook, the receiving portion defining an axial direction. The fastening portion has a first interlocking connector to engage with a first mating interlocking connector provided on the machine tool housing, the interlocking connection between the first interlocking connector and the first mating interlocking connector allowing movement of the holding apparatus in a sliding direction and preventing movement perpendicular to the sliding direction, and in that the securing device can be moved between an open position and a locked position, the securing device being designed to prevent the holding apparatus from moving in the sliding direction in the locked position and to allow movement in the open position.

公开(公告)号：USD948705S1

公开(公告)日：2022-04-12

申请号：US29734930

申请日：2020-05-15

申请人： Vectura Delivery Devices Limited

设计人： Darryl Cotton ,  Roger Clarke ,  John Deamer ,  Andreas Meliniotis

公开(公告)号：US11291672B2

公开(公告)日：2022-04-05

申请号：US15404859

申请日：2017-01-12

申请人： GRACE THERAPEUTICS LLC

发明人： S. George Kottayil ,  Amresh Kumar ,  Prasanna Sunthankar ,  Vimal Kavuru

IPC分类号： A61K31/573 ,  A61K47/12 ,  A61K9/08 ,  A61K47/02 ,  A61K9/00 ,  A61K47/26

摘要： A stable oral spray formulation comprising a glucocorticoid together with other excipients is disclosed. In preferred embodiments, the spray formulation is used to treat neurological disorders such as ataxia by being sprayed in an effective dose into the mouth of a patient.

公开(公告)号：US11286661B2

公开(公告)日：2022-03-29

申请号：US16633698

申请日：2018-07-24

申请人： Hilti Aktiengesellschaft

发明人： Peter Gstach ,  Philipp Grosser ,  Andrin Nigg ,  Daniele Casucci ,  Bernhard Winkler

IPC分类号： E04B1/41 ,  E04C5/00 ,  E04B1/04 ,  E04B1/21 ,  E04G21/14

摘要： A rail assembly is provided, suitable for embedding in concrete, including a profile rail having a rail body, wherein the rail body has a first lateral wall, a second lateral wall, a first rail lip protruding from the first lateral wall, and a second rail lip protruding from the second lateral wall. The rail assembly has a reinforcing element with a force-absorbing body, wherein the force-absorbing body is positioned in front of the first lateral wall of the profile rail for contacting the first lateral wall of the profile rail with the force-absorbing body. A construction body having a concrete element, in which a rail assembly of this type is embedded is also provided.

公开(公告)号：US11280210B2

公开(公告)日：2022-03-22

申请号：US16449849

申请日：2019-06-24

申请人： MTU Aero Engines AG

发明人： Lothar Albers

IPC分类号： F01D11/00 ,  F01D11/12 ,  F04D29/08

摘要： A rotor (10) for a turbomachine, in particular for an aircraft engine, having a rotor base body (12), on which at least one sealing fin (14), which is disposed on a base (16), is provided for cooperating with an associated sealing element (20) of the turbomachine; relative to an axial direction of the rotor (10), the base (16) having a base portion (16a) disposed upstream of the sealing fin (14) and a base portion (16b) disposed downstream thereof, for supporting masks during the coating of sealing fins; the upstream base portion (16a) and the downstream base portion (16b) having different radial distances (A1, A2) to a radially outer sealing tip (18) of the sealing fin (14). Also, a turbomachine having at least one such rotor (10).

公开(公告)号：US11279984B2

公开(公告)日：2022-03-22

申请号：US16470728

申请日：2017-12-19

申请人： ArcelorMittal

发明人： Jean-Marc Pipard ,  Marc Olivier Thenot ,  Pierre Targy

IPC分类号： C21D8/02 ,  C22C38/00 ,  C22C38/06 ,  C22C38/34 ,  C22C38/38 ,  C21D1/19 ,  C22C38/24 ,  C22C38/26 ,  C22C38/28

摘要： A cold rolled steel sheet, the steel containing, in weight percentage, 0.19%≤carbon≤0.24%, 1.9%≤manganese≤2.2%, 1.4%≤silicon≤1.6%, 0.01%≤aluminum≤0.06%, 0.2%≤chromium≤0.5%, phosphorus≤0.02%, sulfur≤0.003%, the balance including iron and unavoidable impurities, the steel sheet having a microstructure containing 5% to 15% of tempered martensite, 10% to 15% of residual austenite, the balance containing bainite, bainite content being at least 70%, is described. Also described is a manufacturing method and with use of such grade for making vehicle parts.

公开(公告)号：US11267552B2

公开(公告)日：2022-03-08

申请号：US16261486

申请日：2019-01-29

申请人： DASSAULT AVIATION

发明人： Aurélien Merlet ,  Zdenek Johan ,  Ximun Loyatho ,  Gilbert Roge

IPC分类号： B64C3/14 ,  B64C7/00 ,  B64C23/04 ,  B64C1/26 ,  B64C3/32

摘要： An aircraft portion includes a fuselage oriented in a longitudinal direction, an airfoil made up of at least one pair of wings arranged on either side of the fuselage in a transverse direction orthogonal to the longitudinal direction, and an airfoil-fuselage junction fairing at the interface between the airfoil and the fuselage. The junction fairing has, in a vertical plane, a lower profile and, in a horizontal plane, a horizontal profile at the junction of the outer surface of the junction fairing with the convex side of each wing. The horizontal profile and/or the lower profile successively has, in the longitudinal direction, a convex front segment, a concave intermediate segment, and a convex rear segment.

公开(公告)号：US11258072B2

公开(公告)日：2022-02-22

申请号：US15126527

申请日：2014-12-18

申请人： Volkswagen AG

发明人： Dustin Banham ,  Brooks Friess ,  Siyu Ye

IPC分类号： H01M4/86 ,  H01M4/88 ,  H01M8/1004 ,  H01M8/1018 ,  H01M8/10

摘要： A catalyst layer (20) for a fuel cell and to a method suitable for producing the catalyst layer (20). The catalyst layer (20) includes a catalyst material (22) containing a catalytic material (24) and optionally porous carrier material (23) on which the catalytic material (24) is supported. The catalyst layer also includes mesoporous particles (21) made from hydrophobic material.

公开(公告)号：US11248484B2

公开(公告)日：2022-02-15

申请号：US15016033

申请日：2016-02-04

申请人： MTU Aero Engines AG

发明人： Steffen Schlothauer ,  Thomas Hess ,  Christian Liebl ,  Richard Scharl ,  Daniel Kirchner ,  Alexander Buck

IPC分类号： F01D11/12 ,  F01D11/08 ,  F01D5/12 ,  B33Y10/00 ,  B33Y80/00

摘要： A gas turbine component for a gas turbine is provided. The gas turbine component has a shell portion having an abradable portion (2) to allow rotor blade ends (1) of a rotor blade array of the gas turbine to rub into the same. The abradable portion adjoins a neighboring portion (3) of the shell portion axially at both sides and is additively manufactured together therewith.