公开(公告)号：US20070197612A1

公开(公告)日：2007-08-23

申请号：US11670594

申请日：2007-02-02

申请人： Heiner Glombik ,  Christian Stapper ,  Eugen Falk ,  Stefanie Keil ,  Hans-Ludwig Schaefer ,  Wolfgang Wendler ,  Stephanie Knieps

发明人： Heiner Glombik ,  Christian Stapper ,  Eugen Falk ,  Stefanie Keil ,  Hans-Ludwig Schaefer ,  Wolfgang Wendler ,  Stephanie Knieps

IPC分类号： A61K31/421 ,  C07D263/34

CPC分类号： C07D263/32

摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.

摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及包含具有环己基甲氧基取代基的乙酸衍生物及其盐的血液的那些胰岛素相关代谢紊乱，例如高脂血症，糖尿病，胰岛素抵抗等。 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。

公开(公告)号：US20070197605A1

公开(公告)日：2007-08-23

申请号：US11672302

申请日：2007-02-07

申请人： Heiner Glombik ,  Christian Stapper ,  Eugen Falk ,  Stefanie Keil ,  Hans-Ludwig Schaefer ,  Wolfgang Wendler ,  Stephanie Knieps

发明人： Heiner Glombik ,  Christian Stapper ,  Eugen Falk ,  Stefanie Keil ,  Hans-Ludwig Schaefer ,  Wolfgang Wendler ,  Stephanie Knieps

IPC分类号： A61K31/4439 ,  A61K31/422 ,  C07D413/02

CPC分类号： C07D263/32

摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with arylcycloalkyl-substituted alkanoic acid derivatives and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.

摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及含有芳基环烷基取代的链烷酸衍生物的乙酸衍生物的血液中诸如高脂血症，糖尿病，胰岛素抵抗等的胰岛素相关代谢紊乱，以及 他们的盐 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。