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1.发明授权2-{-3,′2-(phenyl)-oxazol-4-ylmethoxyl-cyclohexyl methoxy}-propionic acid derivatives used as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes 有权用作治疗高脂血症和糖尿病的过氧化物酶体增殖物激活受体（PPAR）配体的2 - { - 3，“2-（苯基） - 恶唑-4-基甲氧基] - 环己基甲氧基} - 丙酸衍生物公开(公告)号：US07956077B2
公开(公告)日：2011-06-07
申请号：US11671673
申请日：2007-02-06
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： A01N43/76 , C07D263/34
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及包含具有环己基甲氧基取代基的乙酸衍生物及其盐的血液的那些胰岛素相关代谢紊乱，例如高脂血症，糖尿病，胰岛素抵抗等。 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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2.发明授权Arylcycloakyl-substituted alkanoic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes 有权用作治疗高脂血症和糖尿病的过氧化物酶体增殖物激活受体（PPAR）配体的芳基环烷基取代的链烷酸衍生物公开(公告)号：US07598281B2
公开(公告)日：2009-10-06
申请号：US11672302
申请日：2007-02-07
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： A61K31/421 , C07D263/30
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with arylcycloalkyl-substituted alkanoic acid derivatives and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及含有芳基环烷基取代的链烷酸衍生物的乙酸衍生物的血液中诸如高脂血症，糖尿病，胰岛素抵抗等的胰岛素相关代谢紊乱，以及 他们的盐 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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3.发明授权2-{-3-′2-(phenyl)-oxazol-4-ylmethoxymethyl-cyclohexylmethoxy}-propionic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes 有权用作治疗高脂血症和糖尿病的过氧化物酶体增殖物激活受体（PPAR）配体的2- {-3 - [（苯基） - 恶唑-4-基甲氧基甲基 - 环己基甲氧基} - 丙酸衍生物公开(公告)号：US07538131B2
公开(公告)日：2009-05-26
申请号：US11670594
申请日：2007-02-02
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： A61K31/42 , C07D263/30
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及含有环己基甲氧基取代基的乙酸衍生物及其盐的血液中的这些与胰岛素有关的代谢性疾病如高脂血症，糖尿病，胰岛素抵抗等。 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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4.发明申请2-{-3,'2-(PHENYL)-OXAZOL-4-YLMETHOXYL-CYCLOHEXYL METHOXY}-PROPIONIC ACID DERIVATIVES USED AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES 有权用于治疗高脂血症和糖尿病的过氧化物酶促反应激活受体（PPAR）配体的2-（-3 - ， - 2-（苯基） - 唑-4-基甲氧基 - 环己基甲氧基} - 丙酸衍生物公开(公告)号：US20070197613A1
公开(公告)日：2007-08-23
申请号：US11671673
申请日：2007-02-06
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： C07D263/30 , A61K31/421
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及包含具有环己基甲氧基取代基的乙酸衍生物及其盐的血液的那些胰岛素相关代谢紊乱，例如高脂血症，糖尿病，胰岛素抵抗等。 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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5.发明申请2-{-3-'2-(PHENYL)-OXAZOL-4-YLMETHOXYMETHYL-CYCLOHEXYLMETHOXY}-PROPIONIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES 有权2 - { - 3 - {2-（苯基） - 唑-4-基甲氧基甲基 - 环己基甲基}乙酸衍生物作为过氧化物酶促活化受体（PPAR）配体用于治疗高磷脂酰胆碱和糖尿病公开(公告)号：US20070197612A1
公开(公告)日：2007-08-23
申请号：US11670594
申请日：2007-02-02
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： A61K31/421 , C07D263/34
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with cyclohexylmethoxy substituents and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及包含具有环己基甲氧基取代基的乙酸衍生物及其盐的血液的那些胰岛素相关代谢紊乱，例如高脂血症，糖尿病，胰岛素抵抗等。 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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6.发明申请ARYLCYCLOAKYL-SUBSTITUTED ALKANOIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES 有权ARYLCYCLOAKYL-替代的酸性衍生物有效用作治疗高脂血症和糖尿病的过氧化物促进剂激活受体（PPAR）配体公开(公告)号：US20070197605A1
公开(公告)日：2007-08-23
申请号：US11672302
申请日：2007-02-07
申请人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
发明人： Heiner Glombik , Christian Stapper , Eugen Falk , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler , Stephanie Knieps
IPC分类号： A61K31/4439 , A61K31/422 , C07D413/02
CPC分类号： C07D263/32
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid derivatives with arylcycloalkyl-substituted alkanoic acid derivatives and their salts. Known as peroxisome proliferator-activated receptors (PPAR) agonists/antagonists, the invention relates to compounds of the formula I wherein the various substituent R-groups are more specifically defined herein.
摘要翻译： 本发明包括用于治疗代谢紊乱的化合物和组合物，更具体地，涉及含有芳基环烷基取代的链烷酸衍生物的乙酸衍生物的血液中诸如高脂血症，糖尿病，胰岛素抵抗等的胰岛素相关代谢紊乱，以及 他们的盐 被称为过氧化物酶体增殖物激活受体（PPAR）激动剂/拮抗剂的本发明涉及式I化合物，其中各种取代基R基团在本文中更具体地定义。
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7.发明授权Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticals 有权二芳基环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US07160911B2
公开(公告)日：2007-01-09
申请号：US10789019
申请日：2004-02-27
申请人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
发明人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： A61K31/421 , A61K31/422 , C07D263/34 , C07D413/02 , C07D413/04
CPC分类号： C07D263/32
摘要： Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticalsThe invention relates to diarylcycloalkyl derivatives and to their physiologically acceptable salts, racemates and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 二芳基环烷基衍生物，其制备方法及其作为药物的用途本发明涉及二芳基环烷基衍生物及其生理学上可接受的盐，外消旋体和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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8.发明授权Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07173151B2
公开(公告)日：2007-02-06
申请号：US10789324
申请日：2004-02-27
申请人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07C229/00 , C07C61/28 , C07C61/16 , C07C62/00 , C07C62/30
CPC分类号： C07C275/28 , C07C275/10 , C07C275/24 , C07C275/26 , C07C2601/14
摘要： The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 本发明涉及芳基环烷基取代的衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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9.发明授权Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals 有权具有生物异丝氨酸羧酸基团的环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US07148246B2
公开(公告)日：2006-12-12
申请号：US10789865
申请日：2004-02-27
申请人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
发明人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： C07D277/04 , C07D209/54 , C07D257/04 , C07D413/00 , A61K31/42
CPC分类号： C07D417/12 , C07D263/32 , C07D413/12
摘要： Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals The invention relates to cycloalkyl derivatives having bioisosteric carboxylic acid groups and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 具有生物硅烷酸羧酸基团的环烷基衍生物及其制备方法及其作为药物的用途本发明涉及具有生物硅烷酸羧酸基团的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 所描述的是式I化合物，其中自由基如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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10.发明申请Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050215596A1
公开(公告)日：2005-09-29
申请号：US10788997
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/421 , A61K31/422 , A61K31/4439 , A61P3/10 , A61P9/10 , C07D263/30 , C07D263/32 , C07D413/02 , C07D413/04
CPC分类号： C07D263/32 , C07D413/02
摘要： Provided herein are cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals
摘要翻译： 本文提供环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途
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